Clinical trials: Statin Myopathy
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscular Diseases
The Effect of Statin Medications on Muscle Performance (The STOMP Study)
Statins are a group of medications that are used to lower cholesterol levels. Although serious side effects are rare, some people taking statins experience muscle pain or weakness.
- Trial name
- STOMP (NCT00609063)
- Testing
- Atorvastatin
- Where
- 3 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Statin Therapy
The Effect of Q10 and Selen Supplement on Muscular Adverse Events in Statin Therapy
The purpose of this study is to determine whether supplements of Q10 and Selen are effective in reducing muscular adverse events (AE) in statin therapy.
- Trial name
- NCT00113477
- Testing
- Q10, Selen
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Hypercholesterolemia, Myopathy
DNA Diagnostic System for Statin Safety and Efficacy
Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps…
- Trial name
- SIM (NCT00767130)
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Genomas, Inc
Muscular Diseases
Differences in Atorvastatin Metabolite Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity
The primary objective of the study is to investigate whether differences in atorvastatin metabolite ratios might have a positive or negative predictive value in diagnosing atorvastatin muscle toxicity.
- Trial name
- NCT00199745
- Testing
- atorvastatin
- Where
- Norway
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Statin Myopathy
Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design
This study consists of a series of prospective, randomized placebo-controlled n of 1 trials to objectively evaluate the reproducibility of subjective and objective symptoms among patients with a history of statin-related myopathy.
- Trial name
- NCT01259791
- Testing
- Individual-specific statin causing myopathy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pain
Effect of Succinylcholine on Patients Using Statins
Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins.
- Trial name
- NCT00986583
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic
Myopathy, HMG COA Reductase Inhibitor Adverse Reaction
Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS
It is our primary hypothesis that statin drugs impair skeletal muscle mitochondrial function and that ubiquinol (the reduced active form of CoQ10) supplementation will block impairment of PCr recovery kinetics in patients using…
- Conditions
- Myopathy, HMG COA Reductase Inhibitor Adverse Reaction, Hypercholesterolemia
- Trial name
- NCT01702987
- Testing
- ubiquinol, statin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pain, Weakness
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms
This study will evaluate whether a dietary supplement, coenzyme Q10 (CoQ10), will improve muscle symptoms, such as muscle aches, pains, cramps, and/or weakness, which are experienced by some individuals who use statin medications.
- Conditions
- Pain, Weakness, Cramps, Myalgia or Myositis Nos
- Trial name
- NCT01032993
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Catherine Buettner
Hypercholesterolemia, Aches
Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs
The purpose of this study is to determine of creatine will prevent or treat the muscle toxicity side effect of statin drug therapy, whose symptoms are aching, cramping, and weakness.
- Conditions
- Hypercholesterolemia, Aches, Cramps, Weakness
- Trial name
- NCT00797407
- Testing
- Creatine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Cleveland Clinic
Myopathy
Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy
A major contributor to frailty and immobility in the elderly is the age related loss of muscle mass (sarcopenia). Cardiovascular disease (CVD) is the leading cause of mortality in the elderly, with high blood cholesterol and…
- Trial name
- NCT01047163
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Statin Adverse Reaction, Skeletal Myopathy
NIRS to Diagnose SAMS
This proposal seeks to determine whether near infrared spectroscopy (NIRS) can differentiate between patients with confirmed SAMS and those with non-specific muscle complaints.
- Trial name
- NCT03653663
- Testing
- Simvastatin 20 mg
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Pain
Interaction of Statins and Nondepolarizing Muscle Relaxants
provide evidence for prevention or reduction muscle pain.
- Trial name
- NCT02222519
- Testing
- Rocuronium
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huang-wei LV
Muscle Weakness, Myalgia
Coenzyme Q10 in Older Athletes Treated With Statin Medications
The purpose of this study is to evaluate the effect of coenzyme Q10 administration in improving mitochondrial function as measured by anaerobic threshold in older athletes on a stable dose of statin medication.
- Conditions
- Muscle Weakness, Myalgia, Side Effects of Statins
- Trial name
- NCT01026311
- Testing
- Coenzyme q 10
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Richard Deichmann, MD
Myopathic Conditions
Is Myopathy Part of Statin Therapy (IMPOSTER-16)
There is a significant proportion of patients complaining of muscle symptoms while on statin therapy who have a measurable difference in muscle strength or endurance and whose muscle biopsies are diagnostic for myopathy.
- Trial name
- NCT00127335
- Where
- United States
- Sponsor
- Scripps Health
Myopathy
SAPhIRE Statin Adverse Drug Reaction
To find out the pharmacokinetic and genetic risk factors involved in muscular side effects (myalgia) associated with statin therapy.
- Trial name
- STATIN (NCT03042286)
- Where
- Singapore
- Volunteers
- 1,500 people
- Sponsor
- National Heart Centre Singapore
Neuromuscular Blockade, Statin-Associated Myopathy
Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients
This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins.
- Conditions
- Neuromuscular Blockade, Statin-Associated Myopathy, Neuromuscular Monitoring
- Trial name
- NCT06834776
- Testing
- TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.
- Volunteers
- 104 people
- Sponsor
- Ankara City Hospital Bilkent
Statin Myopathy
CoEnzyme Q10 in Statin Myopathy
Statins (such as simvastatin or Zocor) are the most effective and widely prescribed medications to lower cholesterol levels and reduce the frequency of heart attacks, cardiac deaths and strokes.
- Trial name
- NCT01140308
- Testing
- CoEnzyme Q10
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Myopathy (Statin Associated)
Metabolic Features of Post-Myopathy Patients Associated With Statin Treatment
Statins are a class of drugs given to lower cholesterol. Although statins are considered to be generally safe, some studies show that about 10% of people on statins develop muscle-related symptoms, from fatigue (tiredness)…
- Trial name
- NCT01040650
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Cardiovascular Diseases, HMG COA Reductase Inhibitor Adverse Reaction
Physical Activity Levels and Statin Therapy
Rationale: Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS).
- Conditions
- Cardiovascular Diseases, HMG COA Reductase Inhibitor Adverse Reaction, Muscle Pain
- Trial name
- NCT05625945
- Testing
- Physical activity monitoring
- Where
- Netherlands
- Volunteers
- 196 people
- Sponsor
- Radboud University Medical Center
Healthy
Effects of Statins on Pro- and Antioxidant Status : Link With Statin-Associated Myopathy.
To evaluate the effects of a 8-week treatment with 80 mg/day simvastatin on prooxidant and antioxidant status at rest and after exercise, on mitochondrial respiration and calcium release in skeletal muscle, and on aérobic…
- Trial name
- NCT00285181
- Testing
- Simvastatin
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier