Clinical trials: Statin Myopathy
Hypercholesterolemia, Statin-Associated Myopathy
Safety of Red Yeast Rice for High Cholesterol in Individuals With Statin Intolerance
This study will examine the effect of red yeast rice extract compared to pravastatin on muscle related complaints in individuals with high cholesterol who have previously been unable to tolerate statin medications due to muscle…
- Trial name
- NCT00639223
- Testing
- Red Yeast Rice, Pravastatin, Lifestyle modification program
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Pennsylvania
Statin Induced Myalgia
Does Coenzyme Q 10 Supplementation Reduce Muscle Pain Caused by Statins? (Cholesterol Lowering Medications)
The purpose of this study is to determine whether Coenzyme Q 10 supplementation will decrease the rate of Muscle Pain in patients with previous statin related Muscle Pain.
- Trial name
- COSMIC (NCT00716612)
- Testing
- Coenzyme Q 10
- Where
- Israel
- Volunteers
- 37 people
- Sponsor
- Hadassah Medical Organization
Statin Adverse Reaction
Quality of Life in Patients With Statin-Associated Myopathy
The proposed study will focus on possible effects of statins on muscle strength and why they become tired more easily, quality of life, and measurements to understand why muscles are not able to fully utilize fats.
- Trial name
- NCT00850460
- Testing
- Statins
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rockefeller University
Stroke, Rhabdomyolysis
Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2
This trial will be a phase 2 randomized safety study in which ischemic stroke patients will be randomly assigned within 24 hours of symptom onset to placebo or standard dose lovastatin versus short-term high-dose lovastatin 640…
- Conditions
- Stroke, Rhabdomyolysis, Jaundice
- Trial name
- NeuSTART2 (NCT01976936)
- Testing
- Low Dose Lovastatin, High Dose Lovastatin
- Where
- 7 sites in United States
- Volunteers
- 162 people
- Sponsor
- Columbia University
Muscle Cramp, Ache
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
Over 40 million Americans take statins to reduce their risk of atherosclerotic cardiovascular disease (ASCVD). Unfortunately, 10 to 20% stop taking them due to statin-associated muscle symptoms (e.g.
- Conditions
- Muscle Cramp, Ache, Weakness, Muscle, Statin Adverse Reaction
- Trial name
- NCT04507373
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Statin-associated Myalgia
Efficacy and Safety of Coenzyme Q10 in the Treatment of Statin-Associated Myalgia
Statins are medications that lower blood cholesterol by inhibiting cholesterol production in the liver. Overall, statins are well tolerated. Approximately 10% to 15% of patients report muscle aches/pain while taking statins.
- Trial name
- NCT00590408
- Testing
- coenzyme Q10
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Creighton University
HMG COA Reductase Inhibitor Adverse Reaction
Vitamin D Replacement in Statin-Induced Myopathy
Pretreating people with replacement doses of vitamin D will allow them to tolerate Statin medications that have caused muscle pain for them in the past.
- Trial name
- NCT01400009
- Testing
- Vitamin D (Cholecalciferol )
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Statin Adverse Reaction, Statin-induced Myopathy
Metabolic and Mitochondrial Changes in Statin-Induced Myopathy
The goal of this observational study is to learn whether statin-related muscle symptoms are linked to problems in fat metabolism in muscle cells, specifically involving acylcarnitines, in adults taking or not taking statins.
- Trial name
- NCT07511686
- Testing
- Blood sampling and laboratory assessment, Muscle biopsy
- Where
- Latvia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riga Stradins University
Myopathy; Primary
Annatto-derived GG for Statin-associated Myopathy
To evaluate the effects of 3-months annatto-derived geranylgeraniol (GG) supplementation on statin-associated skeletal muscle health.
- Trial name
- GG-statin (NCT05312424)
- Testing
- Low GG, High GG
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Rhabdomyolysis, Myopathy
The Association of Genetic Polymorphisms With Statin-Induced Myopathy.
To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these SNPs and the incidence of…
- Trial name
- NCT00549029
- Testing
- DNA
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Myalgia, Hypercholesterolemia
Study of the Safety and Tolerability Associated With PPD10558 Versus Atorvastatin in Patients Previously Intolerant to Statins Due to Statin-associated Myalgia (SAM)
The purpose of this study is to assess the incidence of statin-associated myalgia (SAM) with treatment with PPD10558 versus atorvastatin in patients previously intolerant to statins.
- Conditions
- Myalgia, Hypercholesterolemia, Hyperlipidemia
- Trial name
- NCT01279590
- Testing
- PPD10558, Atorvastatin
- Where
- 67 sites in United States
- Volunteers
- 282 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Rhabdomyolysis
Pharmacoepidemiology and Pharmacogenetics of a Statin Adverse Event
To conduct a case-control study of factors that increased the risk of rhabdomyolysis, an adverse drug reaction in cerivastatin users
- Trial name
- NCT00241748
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- University of Washington
Statins Induced Myopathy
Dantrolene in Statin-induced Myopathy
Statins are one of the most efficient drugs for the treatment of hypercholesterolemia which is considered as one of the main risk factors for atherosclerosis., and therefore they are frequently prescribed medications [1-2].
- Trial name
- NCT06966843
- Testing
- Dantrolene
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Tanta University
Pain, Soreness
Benefit of CoQ-10 in Patients on Statins
This study will investigate whether a supplement called co-enzyme Q10 can help ease or eliminate some of the side effects that result from taking statin medications.
- Conditions
- Pain, Soreness, Weakness, Fatigue
- Trial name
- CoQ-10 (NCT00997269)
- Testing
- Co-enzyme Q-10
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Stony Brook University
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Myopathy
Muscle Characteristics Associated With Statin Therapy
The purpose of this study is to investigate the mechanism of statin-related myopathy by evaluating muscle samples before and after statin exposure.
- Trial name
- NCT00990834
- Testing
- simvastatin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Scripps Health
Statin-related Muscle Pain, Muscle Aches
7 Tesla MRI Study in Patients With Statin Related Muscle Complaints
Roughly 5-10% of statin-treated patients report muscle pain, aches, weakness, cramps, stiffness, or "heaviness" - typically occurring symmetrically in the legs.
- Conditions
- Statin-related Muscle Pain, Muscle Aches, Muscle Weakness, Muscle Cramp
- Trial name
- NCT04575090
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiovascular Diseases, Dyslipidemias
Efficacy, Safety and Cost-efficacy of a Pre-emptive Genotyping Strategy in Patients Receiving Statins
This is a Phase IV multicentre adaptive single-blinded randomized clinical trial if preemptively genotyping populations at risk of cardiovascular disease susceptible of receiving high or moderate doses of statin therapy is…
- Conditions
- Cardiovascular Diseases, Dyslipidemias, Statin Adverse Reaction, Pharmacogenic Myopathy
- Trial name
- PREVESTATGx (NCT06262685)
- Testing
- Preemptive pharmacogenetic atorvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic simvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pitavastatin dose based on CPIC guidelines
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Statin Intolerance
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes.
- Trial name
- NCT02490527
- Testing
- Pure epicatechin capsules (50mg), Simvastatin (40mg)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego