Clinical trials: Statin Therapy
Myopathy
Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy
A major contributor to frailty and immobility in the elderly is the age related loss of muscle mass (sarcopenia). Cardiovascular disease (CVD) is the leading cause of mortality in the elderly, with high blood cholesterol and…
- Trial name
- NCT01047163
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dyslipidemias, LDL Hyperlipoproteinemia
Red Rice Yeast in Low-density Lipoprotein (LDL) Lowering: an Efficacy Study
Red yeast rice is a source of active compounds in reducing LDL levels with practically no side effects. Molval Fort is a natural product available in the Lebanese market with a combination of red yeast rice extracts, EPA/DHA and…
- Trial name
- NCT03607383
- Testing
- Red Rice Yeast Extract, Statin
- Where
- Lebanon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Atherosclerosis
The Effect of Statin Treatment on Trained Innate Immunity
The innate immune system plays a pivotal role in the development and progression of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting immunological memory after stimulation with various…
- Trial name
- SIMPEL (NCT03354156)
- Testing
- statin treatment
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia Reperfusion Injury, Endothelial Dysfunction
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Rationale: Apart from their cholesterol lowering effects, statins have cholesterol-independent pleiotropic actions, such as upregulation of 5'-ectonucleotidase and up-regulation of NO-synthase that may increase tolerance against…
- Trial name
- NCT00987974
- Testing
- rosuvastatin, atorvastatin 3 days, rosuvastatin 7 days
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Diabetes Mellitus
Living With Statins - Interventional Exercise Study
Background. Statins are cholesterol lowering drugs that are prescribed to lower the risk of cardio-vascular diseases. The use of statins has increased markedly and it is now one of the most prescribed drugs in the world.
- Trial name
- LIFESTAT (NCT02796378)
- Testing
- Training+Simvastatin+Q10
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiovascular Diseases
Impact of Statin Therapy on Adaptations to Aerobic Exercise
The purpose of this study is to determine how different doses of a statin affect muscle health and exercise.
- Trial name
- NCT03360916
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet, Exercise Program
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hyperlipidemias
Effect of Fenofibrate Conversion on Triglyceride Levels in Patients on Statin Therapy
The primary objective of this randomized trial is to measure the impact of converting patients on statin therapy from fenofibrate 160mg to 54mg per day compared to patients who continue fenofibrate 160mg per day for triglycerides.
- Trial name
- NCT01280604
- Testing
- Fenofibrate 54mg
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Cardiovascular Diseases
Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
Atherosclerosis, one major cause of morbidity and mortality worldwide, is a complex and multifactorial disease triggered especially due to high level of plasma lipids and that involves three mainly conditions: chronic…
- Trial name
- NCT02732223
- Testing
- Functional treatment, Control treatment
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Insufficient Physical Activity
A BCT Intervention for Physical Activity Among Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of physical activity (PA) among participants on primary prevention statin…
- Trial name
- NCT05273723
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy Volunteers
A Phase 1 Study to Evaluate the Drug-Drug Interaction Potential Between ALG-055009 and Statin Therapy(Ies)
This Phase 1 study consists of two parts, all conducted in healthy volunteers (HVs). In Parts 1 and 2, the drug-drug interaction (DDI) potential of ALG-055009 will be explored, where subjects will be assigned to receive multiple…
- Trial name
- NCT06191991
- Testing
- Atorvastatin, ALG-055009, Rosuvastatin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Myopathy (Statin Associated)
Metabolic Features of Post-Myopathy Patients Associated With Statin Treatment
Statins are a class of drugs given to lower cholesterol. Although statins are considered to be generally safe, some studies show that about 10% of people on statins develop muscle-related symptoms, from fatigue (tiredness)…
- Trial name
- NCT01040650
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Atrial Fibrillation
Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins
The purpose of this study is to determine the effect of statin therapy for prevention of atrial fibrillation (AF) in pacemaker and non-pacemaker patients with paroxysmal atrial fibrillation in the absence of significant coronary…
- Trial name
- PAFRIOSIES (NCT00321802)
- Testing
- Simvastatin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Aortic Stenosis, Arteriosclerosis
Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statins
Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterolemia, diabetes mellitus and arterial…
- Conditions
- Aortic Stenosis, Arteriosclerosis, Familial Hypercholesterolemia, Conventional Transthoracic Echocardiogram
- Trial name
- NCT03310671
- Testing
- Echocardiogram
- Where
- Spain
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Endothelial Function
Pleiotropism of Statin Therapy in High Dose Versus Low Dose Combined With Ezetimibe
To test the hypothesis that therapy with high dose statin provides endothelial superior benefit to the same cholesterol lowering with low-dose statin combined with ezetimibe.
- Trial name
- NCT01241097
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Bahia
Obstructive Sleep Apnea of Adult
Impact of Intermittent Hypoxia on the Function of the Phagocytes
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA.
- Trial name
- NCT03618719
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hyperlipidemia, Ursodeoxycholic Acid
Ursodeoxycholic Acid Attenuates Statin-Induced Impaired Glucose Tolerance
The purpose of this clinical trial is to understand whether the drug Ursodeoxycholic acid (UDCA) can prevent glucose intolerance in participants with hyperlipidemia who are taking statins. It will also assess the safety of UDCA.
- Conditions
- Hyperlipidemia, Ursodeoxycholic Acid, Statin Therapy, Glucose Intolerance
- Trial name
- URSTAR (NCT06684106)
- Testing
- Ursodeoxycholic acid (UDCA) 500 mg
- Where
- 2 sites in China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Alzheimer Disease
Evaluating Simvastatin's Potential Role in Therapy
The purpose of this study is to see how simvastatin, a cholesterol-lowering drug, affects processes related to the development of Alzheimer's disease, including: 1) levels of a substance called beta-amyloid-42 found in the spinal…
- Trial name
- ESPRIT (NCT00486044)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Yellow Fever Vaccine, Yellow Fever
Yellow Fever Vaccine on Statin/ Non Statin Subjects
Since the 1st pandemic of the 21st century caused by SARS coronavirus, the world has experienced outbreaks of swine origin H1N1 influenza, Ebola and Zika viruses, which have all resulted in global health crises.
- Trial name
- NCT03116802
- Testing
- Stamaril (live attenuated yellow fever vaccine)
- Where
- Singapore
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Medication Adherence
Investigation of a Patient Support Intervention for Statin Medication Adherence
Statins have been demonstrated to significantly reduce the risk of cardiovascular disease, but adherence to these medications is suboptimal.
- Trial name
- NCT06972979
- Testing
- Text Message Gamification and Remote Support
- Where
- United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Ascension Health
Independent Living, Disability Free Survival
A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)
The STAREE study will examine whether treatment with statin (atorvastatin 40mg) compared with placebo will prolong disability free survival and reduce major cardiovascular events amongst healthy elderly people (≥70 years).
- Conditions
- Independent Living, Disability Free Survival, Elderly, Healthy
- Trial name
- STAREE (NCT02099123)
- Testing
- Atorvastatin
- Where
- 6 sites in Australia
- Volunteers
- 9,971 people, healthy volunteers welcome
- Sponsor
- Monash University