Clinical trials: Status Epilepticus
Stroke, Guillain-Barre Syndrome
Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology
This study examines the use of an AI-powered virtual assistant for quickly identifying and handling neurological emergencies, particularly in places with limited medical resources.
- Conditions
- Stroke, Guillain-Barre Syndrome, Facial Palsy, Migraine
- Trial name
- AIDEN (NCT06334796)
- Testing
- Virtual Assistant
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Status Epilepticus
Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2)
Children with seizures are frequently seen in the emergency department. The drug lorazepam, which is commonly used, is not labeled by the US Food and Drug Administration for children for this use.
- Trial name
- NCT00621478
- Testing
- lorazepam or diazepam
- Where
- 14 sites in United States, Canada
- Volunteers
- 259 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Respiratory Failure, Status Epilepticus
Pilot Simulation RCT of Telemedical Support for Paramedics
This study evaluates the impact of video communication via telemedicine on the quality of emergency care provided to children by paramedic teams supported by a remote physician in a simulated out-of-hospital setting.
- Conditions
- Respiratory Failure, Status Epilepticus, Status Asthmaticus, Cardiopulmonary Arrest
- Trial name
- NCT03742167
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston Medical Center
Status Epilepticus
Sustained Effort Network for Treatment of Status Epilepticus/European Academy of Neurology Registry on Refractory Status Epilepticus (SENSE-II/AROUSE)
SENSE-II/AROUSE is a prospective, multicenter registry for patients treated for SE. The primary objective is to document patients and SE characteristics, treatment modalities, EEG features, and outcome of consecutive adults…
- Trial name
- SENSEII/AROUSE (NCT05839418)
- Where
- 11 sites in Austria, Belgium and 6 more
- Volunteers
- 3,000 people
- Sponsor
- Erasme University Hospital
Status Epilepticus
Status Epilepticus in Men and Women: Clinical Presentation, Management, and Outcomes
Sex-specific differences in neurological emergencies such as Status epilepticus (SE) remain understudied despite growing recognition of gender disparities in medicine.
- Trial name
- NCT07443241
- Volunteers
- 779 people
- Sponsor
- University Hospital Marburg
Patient Reported Outcomes, Patient Satisfaction
Patient-reported Outcome and Patient-reported Experience After Status Epilepticus
Status epilepticus (SE) is a common life-threatening neurological emergency in which prolonged or multiple closely spaced seizures can result in long-term impairments.
- Conditions
- Patient Reported Outcomes, Patient Satisfaction, Long Term Outcomes, Status Epilepticus
- Trial name
- POSEIDON2 (NCT06100978)
- Where
- 19 sites in France
- Volunteers
- 145 people
- Sponsor
- Versailles Hospital
Status Epilepticus, Epilepsy
Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus
The main purpose of this study is to know on one hand if lorazepam is more (effective) than clonazepam and on the other hand if lorazepam is also effective as the association clonazepam + fosphenytoin in out-of-hospital treatment…
- Trial name
- LORACLOFT (NCT01870024)
- Testing
- Clonazepam, Fosphenytoin, Lorazepam
- Where
- France
- Volunteers
- 434 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stereotypical Prolonged Seizures
A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
The purpose of the study is to evaluate the long-term safety and tolerability of Staccato alprazolam.
- Trial name
- NCT05076617
- Testing
- Staccato alprazolam
- Where
- 136 sites in United States, Australia and 10 more
- Volunteers
- 300 people
- Sponsor
- UCB Biopharma SRL
Nonconvulsive Status Epilepticus, Seizures
Does Use of Rapid Response EEG Impact Clinical Decision Making
This study is designed as a prospective, non-randomized, observational, multicenter clinical trial. The primary aim of this study is to observe if the use of the rapid responds electroencephalography (EEG) system impacts…
- Trial name
- DECIDE (NCT03534258)
- Testing
- Ceribell Rapid Response EEG, Survey
- Where
- 5 sites in United States
- Volunteers
- 164 people
- Sponsor
- Ceribell Inc.
Status Epilepticus, Electrographic, Coma
VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa
This is a pilot trial of a single loading dose of vigabatrin in post-anoxic status epilepticus.
- Trial name
- VIGAB-STAT (NCT04772547)
- Testing
- Vigabatrin Only Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Epilepsy, Status Epilepticus
Repeated TMS at Low Frequencies to Reduce Seizure Occurrence
Perform non-invasive neuro-navigated repeated Transcranial Magnetic Stimulation (rTMS) at low frequencies (LF) with the intent to reduce the occurrence of seizures over time (long-term protocol).
- Conditions
- Epilepsy, Status Epilepticus, Epilepsia Partialis Continua, Epilepsia Partialis Continua, Refractory (Medically)
- Trial name
- NCT03154307
- Testing
- Low frequency repeated TMS (LF-rTMS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baptist Health South Florida
Status Epilepticus, Epilepsy
Assessment of Adults Epidemiological Characteristics of Status Epilepticus in the French West Indies and in French Guiana
The justification of this prospective and multicenter study is based on the absence of published data concerning, status epilepticus (SE), a pathology which seems frequent in the French West Indies (FWI) and French Guiana, and…
- Trial name
- EpiDFA (NCT05246566)
- Testing
- Routine care
- Where
- 4 sites in France
- Volunteers
- 241 people
- Sponsor
- University Hospital Center of Martinique
Generalized Convulsive Status Epilepticus
Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children
About 40% of children with generalized convulsive status epilepticus (GCSE) are not terminated by first-line benzodiazepines (BDZs), and approximately 50% of BDZ-refractory GCSE are not controlled by second-line antiseizure…
- Trial name
- KLaSSEC (NCT07046611)
- Testing
- Ketamine, Levetiracetam
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Sohag University
Status Epilepticus
LORA-PITA IV General Investigation
Secondary Data Collection:To confirm the effectiveness and safety profiles under the actual medical practice of LORA-PITA in Japan.
- Trial name
- NCT03905798
- Testing
- Lorazepam
- Where
- Japan
- Volunteers
- 206 people
- Sponsor
- Pfizer
Grand Mal Status Epilepticus, Non-convulsive Status Epilepticus
Refractory Status Epilepticus Treatment Study
Identify the most effective dose of valproic acid when used in combination with phenytoin for treatment of patients with refractory status epilepticus, which allow a better clinical course and prognosis of the disease.
- Trial name
- NCT01586208
- Testing
- valproic acid (VPA)
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Universitari de Bellvitge
Comparison, the Efficacy of Levetireacetam
Levetiracetam Versus Phenytoin in Management of Pediatric Status Epilepticus
The study will be conducted on 60 children suffering from status epilepticus who will be admitted to Pediatric Neurology Unit and Pediatric ICU of Tanta Hospital University.
- Conditions
- Comparison, the Efficacy of Levetireacetam, Phenytoin, Management of Pediatric Status Epilepticus
- Trial name
- NCT04176887
- Testing
- Levetiracetam Injection, Phenytoin Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Status Epilepticus, Ketogenic Dieting
Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects.
- Trial name
- NCT05591508
- Testing
- Ketogenic Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Status Epilepticus
Exogenous Ketone Esters for Refractory Status Epileptics
This study aims to investigate the efficacy of add-on exogenous ketone esters for the treatment of children with refractory generalized convulsive status epilepticus
- Trial name
- EKERSE (NCT05674552)
- Testing
- Exogenous ketone ester
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Status Epilepticus
Seizure Rescue Medication: Caregiver Education in a Simulation Setting
1. Design an educational quality improvement program to assess the most effective educational approach on caregiver seizure RM application.
- Trial name
- NCT03562351
- Testing
- Verbal Instructions Educational Intervention, Video Educational Intervention, Mannequin Educational Intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital