Clinical trials: Status Epilepticus
Status Epilepticus, Refractory Status Epilepticus
Feasibility Study: tDCS for Treatment of Refractory Status Epilepticus
Status epilepticus, or recurrent seizures without return to baseline, is a neurologic emergency. Refractory status epilepticus occurs when seizures are resistant to multiple first line anti-seizure medications.
- Trial name
- NCT05934903
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
Refractory Status Epilepticus
Application of tDCS Stimulation in Controlling Refractory Status Epilepticus
The purpose of the study is to assess the efficacy and safety of targeting tDCS stimulation for treatment of Refractory status epilepticus
- Trial name
- tDCS (NCT06344338)
- Testing
- tDCS stimulation
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Xuanwu Hospital, Beijing
Status Epilepticus
Randomized Therapy In Status Epilepticus
This study evaluated the effectiveness and safety of an investigational product (IP), intravenous (IV) ganaxolone, to treat participants with status epilepticus (SE).
- Trial name
- RAISE (NCT04391569)
- Testing
- Ganaxolone
- Where
- 74 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- Marinus Pharmaceuticals
Epilepsy, Dissociative Seizures
Mainz Epilepsy Registry
Prospective longitudinal observational registry study of all patients with epilepsy treated in the Mainz Comprehensive Epilepsy and Sleep Medicine Center with the focus on the course of the disease and quality of life.
- Conditions
- Epilepsy, Dissociative Seizures, Status Epilepticus
- Trial name
- MAINZ-EPIREG (NCT05267405)
- Testing
- no interventions, only observation
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- Johannes Gutenberg University Mainz
Status Epilepticus
Seizure Rescue Medication: Caregiver Education in a Simulation Setting
1. Design an educational quality improvement program to assess the most effective educational approach on caregiver seizure RM application.
- Trial name
- NCT03562351
- Testing
- Verbal Instructions Educational Intervention, Video Educational Intervention, Mannequin Educational Intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Epilepsy, Status Epilepticus
Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus
The purpose of the study is to evaluate the efficacy and safety of levetiracetam , lacosamide and ketamine treatment of refractory status epilepticus.
- Trial name
- NCT02726867
- Testing
- levetiracetam, lacosamide, Ketamine
- Where
- United States
- Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
Epilepticus Status
Clonazepam in Children Status Epilepticus
•Background: Intravenous clonazepam is the most widely used first-line benzodiazepine in Europe for the initial management of status epilepticus in children.
- Trial name
- UHAPA (NCT04287361)
- Testing
- Efficacy of intravenous clonazepam
- Where
- France
- Volunteers
- 310 people
- Sponsor
- University Hospital, Montpellier
Status Epilepticus, Epilepsy
Assessment of Adults Epidemiological Characteristics of Status Epilepticus in the French West Indies and in French Guiana
The justification of this prospective and multicenter study is based on the absence of published data concerning, status epilepticus (SE), a pathology which seems frequent in the French West Indies (FWI) and French Guiana, and…
- Trial name
- EpiDFA (NCT05246566)
- Testing
- Routine care
- Where
- 4 sites in France
- Volunteers
- 241 people
- Sponsor
- University Hospital Center of Martinique
Epilepsy, Brain Injuries
Hybrid Device DIALYTRODE for Multimodal Neuro-monitoring of Patients With Brain Injury and Status Epilepticus
This clinical trial evaluates the safety and diagnostic performance of a newly developed combined catheter that will be implanted into the brain of patients with severe brain injury for short time (up to 28 days) monitoring of…
- Trial name
- NCT03163485
- Testing
- Dialytrode, Standard treatment
- Where
- 2 sites in Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Super-refractory Status Epilepticus
KD Treatment for Super-refractory Status Epilepticus
The purpose of the study is to investigate to evaluate the efficacy and safety of ketogenic diet (KD) as an adjunctive therapy in patients with Super Refractory Status Epilepticus (SRSE) in the intensive care unit (ICU).
- Trial name
- KD (NCT07496749)
- Testing
- the ketogenic diet, Standard Medical Therapy
- Where
- 14 sites in China
- Volunteers
- 84 people
- Sponsor
- Xuanwu Hospital, Beijing
Patient Reported Outcomes, Long Term Outcomes
Patient-reported Outcome After Status Epilepticus
Status epilepticus (SE) is a common life-threatening neurological emergency in which prolonged or multiple closely spaced seizures can result in long-term impairments.
- Conditions
- Patient Reported Outcomes, Long Term Outcomes, Status Epilepticus, Intensive Care Unit
- Trial name
- POSEIDON (NCT05491590)
- Where
- 16 sites in France
- Volunteers
- 66 people
- Sponsor
- Versailles Hospital
Status Epilepticus, Cardiac Arrest With Successful Resuscitation
VIGAB-BIOSTAT: Neuronal Injury Panel Substudy
The purpose of this substudy is to collect and analyze control data to characterize the degree of neuronal injury in PASE patients who have not received vigabatrin to later compare with patients who received this therapy and…
- Trial name
- NCT05000320
- Testing
- Neuronal Injury Panel
- Sponsor
- University of Florida
Convulsive Refractory Status Epilepticus, Status Epilepticus
Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus
The HYBERNATUS-II study is a phase-III, open-label, randomized controlled trial in patients with convulsive refractory SE receiving mechanical ventilation.
- Trial name
- HYBERNATUS II (NCT07383779)
- Testing
- Targeted Hypothermia
- Where
- 20 sites in France
- Volunteers
- 466 people
- Sponsor
- Versailles Hospital
Status Epilepticus
Status Epilepticus in the Critically Ill Patients
Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset…
- Trial name
- NCT03457831
- Where
- 20 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ictal Group
Status Epilepticus, Convulsive Status Epilepticus
Predictors of Outcomes of Convulsive Status Epilepticus
Status epilepticus is a life-threatening neurological emergency characterized by prolonged seizures or multiple seizures occurring without the patient regaining consciousness between episodes.
- Trial name
- NCT07853391
- Volunteers
- 100 people
- Sponsor
- Assiut University
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Epilepsy, Status Epilepticus
Lacosamide Intravenous Injection for Emergency Termination of Status Epilepticus
Status epilepticus (SE) is an acute and critical form of neurological and systemic diseases involving multiple clinical disciplines, with an annual incidence of (20-73) per 100,000 people and a clinical case fatality rate of 20%.
- Trial name
- NCT06966830
- Testing
- Lacosamide (LCM)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Respiratory Failure, Status Epilepticus
Pilot Simulation RCT of Telemedical Support for Paramedics
This study evaluates the impact of video communication via telemedicine on the quality of emergency care provided to children by paramedic teams supported by a remote physician in a simulated out-of-hospital setting.
- Conditions
- Respiratory Failure, Status Epilepticus, Status Asthmaticus, Cardiopulmonary Arrest
- Trial name
- NCT03742167
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston Medical Center
Epilepsy
Lacosamide in Neonatal Status Epilepticus
Lacosamide in neonatal status epilepticus
- Trial name
- NCT05291455
- Testing
- Lacosamide, Phenobarbital
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sherief Abd-Elsalam