Clinical trials: Status Epilepticus
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Non-Convulsive Status Epilepticus
Fast Acute Sedation at Intensive Care vs. High-dose i.v. Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus (FAST-trial)
This open-label, randomized multicenter trial aims at clarifying the standard of care of patients with non-convulsive status epilepticus not responding to treatment with benzodiazepines and at least one high-dose intra venous…
- Trial name
- FAST (NCT05263674)
- Testing
- Rapid sedation
- Where
- 5 sites in Denmark
- Volunteers
- 140 people
- Sponsor
- University of Southern Denmark
Status Epilepticus, Coma
Rapid-Response EEG in Children With Suspected Status Epilepticus
Seizures are common in children (~350 per 100,000 patients per year) and require immediate medical attention. If the seizure is prolonged (> 5 minutes) it is called status epilepticus and delayed treatment leads to higher risk in…
- Trial name
- RECS (NCT06564662)
- Testing
- Rapid Response EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital at Montefiore
Grand Mal Status Epilepticus
Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus
This study is a randomized, open label, parallel group,comparing the safety and efficacy of valproate and levetiracetam in patients of age group 1 to 16 years with status epilepticus not responded to phenytoin and benzodiazepines…
- Trial name
- NCT02920060
- Testing
- Intravenous levetiracetam, Sodium valproate
- Volunteers
- 80 people
- Sponsor
- Banaras Hindu University
Status Epilepticus
SURESTEP: Transcranial Direct Current Stimulation in Super Refractory Status Epilepticus
The purpose of this study is to determine whether transcranial direct current stimulation affects super refractory status epilepticus.
- Trial name
- SURESTEP (NCT03819543)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Status Epilepticus, Seizure
EEG in In-hospital Patients With Seizure or Altered Mental State
In Kuopio University Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use.
- Conditions
- Status Epilepticus, Seizure, Altered Mental Status
- Trial name
- NCT02383745
- Testing
- Acute EEG with fast EEG electrode
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital
Stroke, Acute, TBI
Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement
There is currently no prospective study analyzing the effect of tracheostomy with bedside simultaneous gastrostomy versus tracheostomy with delayed gastrostomy placement (TSG versus TDG) on the outcomes of neurocritically-ill…
- Conditions
- Stroke, Acute, TBI, Neuromuscular Diseases, Status Epilepticus
- Trial name
- BEGASTON (NCT04758052)
- Testing
- Timing of placement
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Psychomotor Status, Schizophrenia
The Motor Neurological Soft Signs (MNSS) in Persons With Schizophrenia
The aim is to contribute to the knowledge of the relationship between Motor Neurological Soft Signs (MNSS) and schizophrenia, as well as to point out the implications and recommendations for clinical and rehabilitative practices…
- Conditions
- Psychomotor Status, Schizophrenia, Motor Skills Disorders
- Trial name
- MNSS (NCT04495998)
- Testing
- Brief Motor Scale_portuguese version (BMS_pt)
- Where
- Portugal
- Volunteers
- 103 people
- Sponsor
- Faculdade de Motricidade Humana
Epilepsia Partialis Continua, Kojewnikov's Epilepsy
Clobazam Use in Epilepsia Partialis Continua - Pilot Study
The purpose of this study is to evaluate whether clobazam, brand name Onf®, is more effective as an adjunctive or monotherapy in terminating Epilepsia Partialis Continua (EPC) than either lorazepam and/or clonazepam.
- Conditions
- Epilepsia Partialis Continua, Kojewnikov's Epilepsy, Epilepsy
- Trial name
- NCT02134366
- Testing
- Clobazam, Clonazepam, Lorazepam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The Cooper Health System
Epilepticus Status
Clonazepam in Children Status Epilepticus
•Background: Intravenous clonazepam is the most widely used first-line benzodiazepine in Europe for the initial management of status epilepticus in children.
- Trial name
- UHAPA (NCT04287361)
- Testing
- Efficacy of intravenous clonazepam
- Where
- France
- Volunteers
- 310 people
- Sponsor
- University Hospital, Montpellier
Epilepsy in Children
The "New" Place of LEVETIRACETAM in the Management of Status Epilepticus in Children
Status epilepticus is the leading neurological emergency in children, with mortality 2-7% and significant morbidity (10-20%). It is defined as the occurrence of a crisis lasting more than 5 minutes and requiring the…
- Trial name
- LEVET (NCT06498362)
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Strasbourg, France
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Generalized Convulsive Status Epilepticus, Intensive Care Unit
Efficacy Study of Intravenous Sodium Valproate in Addition to First Line Anti Epileptic Treatment of Generalized Convulsive Status Epilepticus.
Study Hypothesis Generalized Convulsive Status Epilepticus (GCSE) is a medical emergency associated with an increased morbidity and a prolonged length of hospital stay.
- Trial name
- VALSE (NCT01791868)
- Testing
- Intravenous Sodium Valproate
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Epilepticus
Study of Midazolam in Healthy Adults
This study is a phase 1, open-label, crossover, comparison study to evaluate the safety and pharmacokinetics (PK) of a single IM administration of 10 mg midazolam using Rafa's auto-injector compared with seizalam in healthy…
- Trial name
- NCT04679623
- Testing
- Midazolam, Seizalam
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rafa Laboratories
Refractory Status Epilepticus
Ketamine for the Treatment of Refractory Status Epilepticus
This pilot feasibility study aims to examine how the timing of ketamine introduction as a third-line anti-seizure medication infusion relates to seizure cessation in patients with refractory status epilepticus (RSE).
- Trial name
- NCT07177235
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Super-refractory Status Epilepticus
KD Treatment for Super-refractory Status Epilepticus
The purpose of the study is to investigate to evaluate the efficacy and safety of ketogenic diet (KD) as an adjunctive therapy in patients with Super Refractory Status Epilepticus (SRSE) in the intensive care unit (ICU).
- Trial name
- KD (NCT07496749)
- Testing
- the ketogenic diet, Standard Medical Therapy
- Where
- 14 sites in China
- Volunteers
- 84 people
- Sponsor
- Xuanwu Hospital, Beijing
Convulsive Status EPILEPTICUS
Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)
The goal of this pragmatic, decentralized, pre-consented, event-driven, randomized controlled trial is to investigate the efficacy of add-on ketamine to second-dose midazolam for prehospital treatment of epileptic children with…
- Trial name
- PEAK-SEEK (NCT07095842)
- Testing
- Ketamine, Midazolam
- Where
- Egypt
- Volunteers
- 668 people
- Sponsor
- Sohag University
Electrical Status Epilepticus in Sleep
Electrical Status Epilepticus in Sleep: Response of Neuropsychological Deficits and Epileptiform Activity to Clobazam Treatment
Electrical status epilepticus in sleep (ESES) is a pattern of abnormal discharges in the electroencephalogram (EEG). Children who have this pattern present seizures and neuropsychological regression.
- Trial name
- ESES-Clobazam (NCT02127918)
- Testing
- ESES treated with clobazam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Boston Children's Hospital
Status Epilepticus, Cardiac Arrest With Successful Resuscitation
VIGAB-BIOSTAT: Neuronal Injury Panel Substudy
The purpose of this substudy is to collect and analyze control data to characterize the degree of neuronal injury in PASE patients who have not received vigabatrin to later compare with patients who received this therapy and…
- Trial name
- NCT05000320
- Testing
- Neuronal Injury Panel
- Sponsor
- University of Florida
Rolandic Epilepsy, Nocturnal Frontal Lobe Epilepsy
The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment Study
In clinical practice language impairment is frequently reported in association with nocturnal epileptiform activity. There is a spectrum of epileptic conditions that are characterized by nocturnal epileptiform activity.
- Conditions
- Rolandic Epilepsy, Nocturnal Frontal Lobe Epilepsy, Landau-Kleffner Syndrome, Electrical Status Epilepticus During Slow Wave Sleep
- Trial name
- REL (NCT01335425)
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center