Clinical trials: Stem Cells
Hydatidiform Mole
A Multi-center Cohort Study of Hydatidiform Mole in China (CN-HM-01)
This observational study aims to establish a national cohort of patients with hydatidiform mole (molar pregnancy) to investigate its malignant transformation rate and malignant transformation mechanisms, with the goal of…
- Trial name
- CN-HM-01 (NCT07202728)
- Testing
- No intervention
- Where
- 14 sites in China
- Volunteers
- 1,489 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Non Hematologic Cancers
Phase I Dose Escalation Study of VS-6063 in Japanese Subjects With Non-Hematologic Malignancies
This is a phase I, open-label, dose-escalation trial of defactinib (VS-6063), a focal adhesion kinase inhibitor, in Japanese patients with non-hematologic malignancies.
- Trial name
- NCT01943292
- Testing
- Defactinib
- Where
- Japan
- Volunteers
- 9 people
- Sponsor
- Verastem, Inc.
Cancer, Hematological
Pre-Exercise for Allogeneic Stem Cell Transplant Patients
The PRESENT-P study is a one-arm exercise intervention study for hematological cancer patients prior allogeneic stem cell transplantation (allo-HCT).
- Trial name
- PRESENT-P (NCT03080792)
- Testing
- Experimental: moderate to high-intensity exercise
- Where
- 5 sites in Germany
- Volunteers
- 14 people
- Sponsor
- University Hospital Heidelberg
Disorder of Upper Respiratory System, Laryngostenosis
Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants
This study aims to test a new groundbreaking treatment for narrowing of the voicebox and upper windpipe, which can be due to injury, inflammatory disease or cancer treatment.
- Conditions
- Disorder of Upper Respiratory System, Laryngostenosis, Tracheal Stenosis
- Trial name
- RegenVOX (NCT01977911)
- Testing
- Stem cell based tissue engineered partial laryngeal implants
- Where
- United Kingdom
- Sponsor
- University College, London
Intrauterine Adhesion
Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions
To observe the clinical safety of intrauterine injection of human embryonic stem cell derived mesenchymal cells in the treatment of moderate and severe intrauterine adhesion, and to preliminarily explore its clinical…
- Trial name
- NCT04232592
- Testing
- Inject a solution of stem cell preparation, Inject stem cells
- Volunteers
- 32 people
- Sponsor
- Qi Zhou
Diffuse Large B Cell Lymphoma
Selinexor Combined With BEAM for ASCT in R/R DLBCL With MYC Positive
To evaluate the efficacy and safety of selinexor combined with BEAM pretreatment regimen in ASCT of recurrent and refractory DLBCL patients with immunohistochemical positive for MYC
- Trial name
- NCT06652139
- Testing
- selinexor combined with BEAM regimen, BEAM regimen
- Volunteers
- 82 people
- Sponsor
- Ruijin Hospital
GVHD
Fecal Microbiota Transplant (FMT) Capsule for Improving the Efficacy of GI-aGVHD
This study aims to determine whether the fecal microbiota transplant (FMT) capsule improves the response rate of GI-aGVHD in patients with glucocorticoid-refractory acute graft vs.
- Trial name
- NCT05094765
- Testing
- FMT
- Volunteers
- 15 people
- Sponsor
- Shenzhen Xbiome Biotech Co., Ltd.
COVID, Pulmonary Infection
Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients
Novel Coronavirus (2019nCoV) or Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) that causes Coronavirus Disease 2019, or known as Covid-19 has recently become a global health emergency since it was first detected in…
- Conditions
- COVID, Pulmonary Infection, Sars-CoV2
- Trial name
- NCT04457609
- Testing
- Oseltamivir, Azithromycin, Umbilical Cord Mesenchymal Stem Cells
- Where
- 4 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Acute Coronary Artery Syndrome
Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase II
The purpose of this randomized, multi-site, clinical trial is to determine whether intensive therapy consisting of cholesterol-lowering statin drugs plus apheresis to cleanse the blood of low-density lipoprotein (LDL) cholesterol…
- Trial name
- PREMIER (NCT02347098)
- Testing
- intensive LDL-lowering therapy, standard statin monotherapy
- Where
- 4 sites in United States
- Volunteers
- 270 people
- Sponsor
- VA Office of Research and Development
Covid19
Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells for Treatment of COVID-19 Acute Respiratory Distress
This is a Phase 2 study to assess COVI-MSC in the setting of current standard of care in hospitalized subjects with RT-PCR confirmed SARS-CoV-2 (COVID-19) infection and acute respiratory distress / acute respiratory distress…
- Trial name
- NCT04905836
- Testing
- COVI-MSC
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sorrento Therapeutics, Inc.
Liver Transplant; Complications, Liver Diseases
Adipose-Derived Mesenchymal Stem Cell for Preventing Biliary Complications
The purpose of this study is to assess the safety of autologous Adipose-Derived Mesenchymal Stem Cell for use in End-Stage Liver Disease patients undergoing the creation of a duct-to-duct anastomosis during Living Donor Liver…
- Trial name
- NCT06649864
- Testing
- Autologous adipose derived mesenchymal stromal cells (AMSC)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Hematological Malignancies, Stem Cell Transplantation
A Prospective Registry for Febrile Events in Patients With Malignant Hemopathies or Subjected to Haematopoietic Stem Cell Transplant
Hema e-chart is an electronic case record that can be changed in real time and is based on the chronological organisation of the infective events and the therapies prescribed.
- Trial name
- HEMA E-CHART (NCT01069887)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Catholic University of the Sacred Heart
GVHD,Acute, Biomarker
Role of aGVHD Biomarkers on aGVHD Risks
To establish risk rating criteria of biological protein marker, determine the role and consistency of aGVHD biomarkers in aGVHD diagnosis and aGVHD prognosis, and evaluate the the impact on non-relapse mortality and relapse and…
- Trial name
- GVHD (NCT04284904)
- Testing
- aGVHD biomarker
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
CMV Viremia, CMV Disease
Expanded Access Protocol of ATA230 (Third-Party Donor-Derived CMV-CTLs) for the Treatment of CMV Viremia or Disease
This is an expanded access protocol designed to provide access of ATA230 to subjects with cytomegalovirus (CMV) viremia or disease, who are intolerant to, or failed, standard antiviral therapy and have no comparable treatment…
- Trial name
- NCT03010332
- Testing
- Cytomegalovirus-specific Cytotoxic T Lymphocytes (CMV-CTLs)
- Sponsor
- Atara Biotherapeutics
Treatment-Related Cancer
Acupressure for Children in Treatment for a Childhood Cancer
Background: Despite advances in symptom management, children undergoing cancer treatment or receiving a chemotherapy-based Hematopoietic Stem Cell Transplant (HSCT) often suffer from moderate to severe symptoms of…
- Trial name
- ACT-CC (NCT03313193)
- Testing
- Acupressure for Children in Treatment for a Childhood Cancer
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of California, San Francisco
Combination of SVF and PRP for Androgenetic Alopecia
Adipose Tissue Derived Stem Cell Based Hair Restoration Therapy for Androgenetic Alopecia
Androgenetic alopecia (AGA) is a common form of hair loss in both men and women, characterized by progressive patterned loss of hair from the scalp.
- Trial name
- AGA (NCT02865421)
- Testing
- stem cells, platelet rich plasma
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Brain and Central Nervous System Tumors
Carboplatin, Temozolomide, and Filgrastim in Treating Patients With Newly Diagnosed or Recurrent High-Grade Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00006263
- Testing
- filgrastim, carboplatin, temozolomide
- Where
- United States
- Sponsor
- NYU Langone Health
HIV
Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 Individuals
To find out if it is possible for HIV-1 patients to maintain antiretroviral medications during allogeneic bone marrow transplant
- Trial name
- NCT01836068
- Testing
- Enfuvirtide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Diabetic Nephropathy Type 2
Human Umbilical Cord Mesenchymal Stem Cell Infusion for Type 2 Diabetic Nephropathy
Diabetic nephropathy (DN) is a chronic kidney disease caused by diabetes. It is one of the most common and most serious microvascular complications of diabetes. Current treatment options for DN are limited.
- Trial name
- NCT07769671
- Testing
- Human umbilical cord mesenchymal stem cell injection
- Where
- China
- Volunteers
- 49 people
- Sponsor
- The First People's Hospital of Changzhou
Endocrine System Diseases, Osteoporosis
Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell Transplant
Allogeneic hematopoietic stem cell transplantations (allo-HSCT) is often indicated in malignant hematologic diseases. Conditioning regimens, used to reduce the tumor burden and to prevent transplant rejection, are based on…
- Conditions
- Endocrine System Diseases, Osteoporosis, Metabolic Syndrome, Adrenal Insufficiency
- Trial name
- ENDOCALLOGREFF (NCT04488432)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Brest
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