Clinical trials: Stenoses
Carotid Artery Stenosis, Superficial Femoral Artery Stenosis
VFI in Healthy Vessels
There is a wealth of evidence implicating the important role of blood flow throughout all stages of the process of atherogenesis.
- Trial name
- NCT05451485
- Testing
- Blood speckle tracking, Ultrasound particle Imaging Velocimetry, 4D flow MRI
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Hypospadias Repair
Hemostasis During Hypospadias Surgery
A comparison between the two hemostatic methods of hypospadias repairing operation, in terms of early and mid-term (up to 6 months) failure rate (wound dehiscence and urethral stricture needing reoperation) between the two…
- Trial name
- NCT02268019
- Testing
- tourniquet application, epinephrine injection
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Isfahan University of Medical Sciences
Mitral Valve Stenosis
Three Dimensional Versus Two Dimensional Echocardiography in Assessment of Severity and Scoring of Rheumatic Mitral Stenosis.
Although the prevalence of rheumatic fever is decreasing in developed countries, it still affects numerous areas in the non- industrialized world.
- Trial name
- NCT04968431
- Testing
- 2D Echocardiography, 3D Echocardiography
- Volunteers
- 60 people
- Sponsor
- Assiut University
Peripheral Arterial Disease, Carotid Stenosis
EValuation of Systemic Atherothrombosis in Patients With ARTerial Disease of the Lower Limbs
The purpose of this study is to determine the prevalence and risk factors, at the time of the diagnosis of PAD, for asymptomatic carotid stenosis and abdominal aortic aneurysm.
- Conditions
- Peripheral Arterial Disease, Carotid Stenosis, Abdominal Aortic Aneurysm
- Trial name
- EVART (NCT01224600)
- Testing
- patients with newly diagnosed PAD (<1year)
- Where
- 115 sites in Belgium, France
- Volunteers
- 1,056 people
- Sponsor
- Institut de l'Atherothrombose
Coronary Artery Disease Left Main
Imaging and Physiology for Intermediate Left Main Stem Stenosis
The present research aims to determine the impact of stenoses in downstream vessels on the FFR and iFR measurements of left main coronary artery (LMCA) stenoses of intermediate severity as determined by coronary angiography.
- Trial name
- VIP-LMS (NCT04531007)
- Testing
- iFR/ FFR/ IVUS/ OCT
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Calcific Aortic Valve Disease, Aortic Valve Stenosis
Serum and Cellular Biomarkers for Aortic Valve Stenosis
AthenaValve aims to develop and initial validate a novel serum diagnostic kit, for the assessment of severity and prognosis of progression of aortic valve stenosis (AS, a devastating disease without early diagnosis and medical…
- Conditions
- Calcific Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve, Calcification of
- Trial name
- AthenaValve (NCT04312139)
- Testing
- Echocardiography, Computerized Tomography Aortic Valve Calcium Score, Untargeted LC/MS and LC-MS/MS
- Where
- 2 sites in Greece
- Volunteers
- 280 people
- Sponsor
- National and Kapodistrian University of Athens
Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic
Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy
This study will investigate whether there is an association between insulin resistance and cardiac function in children with dilated or hypertrophic cardiomyopathy.
- Conditions
- Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Insulin Resistance
- Trial name
- NCT04222101
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
Phimosis, Foreskin; Tightness
Safety and Efficacy of the Sterile Single-use Circular Stapling Device CIRCCURER II (Jiangxi Langhe Medical Instrument Co., Ltd., Guangzhou, China)
Evaluation of the safety and efficacy of the sterile single-use circular stapling device CIRCCURER II (Jiangxi Langhe Medical Instrument Co., Ltd., Guangzhou, China) in comparison with circumcision in adults patients with…
- Conditions
- Phimosis, Foreskin; Tightness, Redundant Prepuce
- Trial name
- CiCi-2021 (NCT04902898)
- Testing
- Circumcision in adults using sterile single-use circular stapling device, Circumcision in adults
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Aortic Stenosis
Vivio AS (Aortic Stenosis) Algorithm Optimization Study
Optimize a candidate software algorithm using data collected with the Vivio system for use as an aid in the identification of heart sounds associated with severe aortic stenosis
- Trial name
- NCT04068402
- Testing
- Vivio System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ventric Health, LLC
Carotid Artery Plaque, Mannose-Binding Lectin Complement Pathway
Lectine Pathway in Unstable Carotid Plaque
The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical…
- Trial name
- NCT03822195
- Testing
- Carotid endoarterectomy
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Aortic Stenosis
PRospective Evaluation Complementing Investigation With Acurate Neo Device
The study collects real-world data of patients who were treated with the Acurate Neo TAVI System and evaluates early and midterm clinical outcomes.
- Trial name
- PRECISA (NCT03846557)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- 10 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Fundación EPIC
Carotid Artery Stenosis Asymptomatic, Carotid Atherosclerosis
Carotid Plaque RADS vs CPVH: Diagnostic Accuracy Comparison
This study compares two methods for assessing carotid artery plaques - deposits of cholesterol and other substances that can build up in the neck arteries and potentially lead to stroke.
- Trial name
- CPVH-P-RADS (NCT07870512)
- Testing
- Carotid Ultrasound with CPVH and Carotid Plaque RADS Assessment
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Limited Liability Company "European Institute of Family Health"
Lumbar Spinal Stenosis
Development and Validation of a Questionnaire for Assessing Activity Limitation in Patients With Lumbar Spinal Stenosis : The Cochin L3S Questionnaire
To develop and validate a questionnaire aiming at assessing specific activity limitation in patients with lumbar spinal stenosis (LSS).
- Trial name
- CL3S (NCT03918512)
- Testing
- nine online self-administered questionnaires
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease, Inflammatory Bowel Diseases
Stricture Definition and Treatment (STRIDENT) Endoscopic Therapy Study
Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Stricture; Bowel
- Trial name
- STRIDENT (NCT03222011)
- Testing
- Standard (single) endoscopic stricture dilatation, Intensive endoscopic stricture dilatation
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- St Vincent's Hospital Melbourne
Spondylolisthesis, Facet Joint Hypertrophy
Caudal Block Versus Quadratus Lumborum Plane Block in Lumbar Surgery
Postoperative pain is a common complication after lumbar spine surgery due to inherent tissue damage during surgical procedures. Many analgesic options have been explored.
- Conditions
- Spondylolisthesis, Facet Joint Hypertrophy, Spinal Canal Stenosis
- Trial name
- NCT06398600
- Testing
- Caudal, Quadratus lumborum plane block
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Fayoum University Hospital
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)
Cardiomyopathy in children is a serious disease which can result in death, disability, heart transplantation or serious heart rhythm disorders. Doctors know little about the causes of cardiomyopathy but would like to learn more.
- Conditions
- Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT01873963
- Where
- 12 sites in United States, Canada
- Volunteers
- 544 people
- Sponsor
- Wayne State University
Severe Aortic Valve Stenosis
A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis
This study will include patients with severe degenerative aortic stenosis (AS) who meet the inclusion criteria and voluntarily participate (planned to undergo TAVI), as well as patients with aortic stenosis who have not undergone…
- Trial name
- NCT07335900
- Testing
- Transcatheter Aortic Valve Implantation, Optimal medication treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- RenJi Hospital
Healthy, Hypertrophic Cardiomyopathy
Investigation Into the Use of Ultrasound Technique in the Evaluation of Heart Disease
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into the circulation.
- Conditions
- Healthy, Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy
- Trial name
- NCT00001632
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Artery Stenosis, Carotid Artery Diseases
Study on the Trans-Carotid Artery Occlusion Shunt System Combined With Introducer Sets
The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets for Cerebral Protection During Carotid Angioplasty
- Trial name
- NCT06959628
- Testing
- Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shenzhen Wecan Medical Technology Co.,Ltd
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University