Clinical trials: Stent Implantation
Coronary Artery Disease (CAD)
Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel (TRIGGER-PCI)
To determine the efficacy of prasugrel versus clopidogrel for the reduction of adverse cardiovascular outcomes in patients with high platelet reactivity on clopidogrel after successful implantation of coronary drug-eluting…
- Trial name
- TRIGGER-PCI (NCT00910299)
- Testing
- Prasugrel, Clopidogrel
- Where
- 27 sites in United States, Germany
- Volunteers
- 423 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Disease, Dyslipidemias
Comparative Study of Rosuvastatin/Ezetimib 20/10 mg and Atovastatin/Ezetimib 40/10 mg (TOLERANT Trial)
the investigators would like to compare the differences between roschvastin and atovastatin in patients who require high-dose statin/ejetimib to undergo a new generation of drug elution stent implantation for cardiovascular…
- Trial name
- NCT05910476
- Testing
- a high dose of statin/ezetimib
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Coronary Stenosis
ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)
The objective of this prospective, single-blind clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI
- Trial name
- NCT03507777
- Testing
- Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 2,487 people
- Sponsor
- Abbott Medical Devices
Glaucoma, Open-Angle
Retrospective Review of Xen Gel Stent Implantation With Open vs. Closed Conjunctiva Approach
To measure surgical success of open vs closed conjunctiva with Xen implantation.
- Trial name
- NCT04406467
- Testing
- Xen Gel Stent
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Johns Hopkins University
Glaucoma Eye
An Innovation in Glaucoma Surgery: XEN45 Gel Stent Implantation
Purpose: To report the follow-up data for patients who had XEN45 gel stent implantation, a new method of minimally invasive glaucoma surgery (MIGS).
- Trial name
- NCT03138928
- Testing
- XEN45 gel stent implantation in glaucoma surgery
- Volunteers
- 15 people
- Sponsor
- Trakya University
Atherosclerosis, Neointima
Effect of Low-dose vs. High-dose Pitavastatin on In-stent Restenosis
To compare low dose (1mg) pitavastatin and high dose (4mg) pitavastatin on neointimal hyperplasia and atherosclerosis progression by using optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) at 12 months…
- Conditions
- Atherosclerosis, Neointima, Angina
- Trial name
- ELEVATE (NCT02545231)
- Testing
- Pitavastatin 1mg, Pitavastatin 4mg
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Korea University Anam Hospital
Coronary Artery Disease
Duration of Clopidogrel Therapy After Drug-Eluting Stent (DES-LATE)
This is randomized-controlled trial to evaluate the difference of composite of cardiac death, myocardial infarction, or Stroke between the dual antiplatelet therapy group and the aspirin monotherapy group after 1-year of…
- Trial name
- DES-LATE (NCT01186146)
- Testing
- Aspirin monotherapy, Aspirin,Clopidogrel
- Where
- 19 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Seung-Jung Park
Stable Angina, Coronary Stenosis
Optical Coherence Tomography to Investigate FFR-Guided DEB-only Elective Coronary Angioplasty
We aimed to evaluate feasibility and the 6-month angiographic and OCT results of FFR - guided use of paclitaxel-eluting balloons (Sequent Please™, B Braun) with provisional bare metal stenting for elective PCI of de novo coronary…
- Trial name
- OCTOPUS-2 (NCT02120859)
- Testing
- FFR - guided DEB angioplasty, Provisional bare metal stenting
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Jena
Coronary Artery Disease, In-stent Restenosis
To Study and Explore the Predictive Effect of Insulin Resistance-related Indicators on In-stent Restenosis After Coronary Stent Implantation
Based on previous studies on insulin resistance and cardiovascular diseases, we believe that the insulin resistance metabolic score also has certain predictive value for the prognosis of in-stent restenosis after coronary stent…
- Trial name
- NCT07614763
- Testing
- Observational studies do not design intervention measures
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Artery Disease
Tailored Anti-platelet Therapy After DES Implantation in High-risk Patients
Clopidogrel monotherapy has been found effective in reducing ischaemic cardiovascular and haemorrhagic complications in patients with drug-eluting stent (DES) placement.
- Trial name
- NCT05936606
- Testing
- Clopidogrel monotherapy, Tailored anti-platelet therapy
- Where
- South Korea
- Volunteers
- 3,434 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Pressure-wire Guided PTCA: Drug Eluting Stent Versus Drug Eluting Balloon (WinDEB Study)
The aim of the study is to show the safety and efficacy of the SeQuent® Please (Drug Eluting Balloon or DEB) vs. commonly used Drug Eluting Stents in the treatment of small vessel disease and side branches by pressure wire guided…
- Trial name
- NCT01399463
- Testing
- Angioplasty performed via Paclitaxel Eluting Balloon catheter, Angioplasty via DES
- Sponsor
- Medical University of Vienna
Lenses, Intraocular, Glaucoma Filtration Implants
Visual Function and Patient Satisfaction in Glaucoma or Ocular Hypertensive Patients Undergoing Simultaneous Cataract Surgery and i-Stent Implantation
New extended depth of focus intraocular lenses (IOLs) are being used in a broader spectrum of patients than trifocal IOLs. The purpose of this study is to evaluate visual improvement after cataract surgery in patients with…
- Trial name
- NCT05392738
- Testing
- I-Stent implantation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Clínica Rementería
STEMI, STEMI (ST Elevation MI)
Pilot Study of IC14 (Atibuclimab), an Anti-CD14 Monoclonal Antibody, to Treat STEMI
Adults who have had an ST-elevation myocardial infarction and were treated with stent placement will receive an intravenous infusion of a monoclonal antibody in order to prevent further heart muscle damage.
- Conditions
- STEMI, STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction (MI), Stent Implantation
- Trial name
- NCT06678074
- Testing
- Atibuclimab (IC14), 20 mg/kg intravenously, once
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Implicit Bioscience
Ischemic Heart Disease
Clopidogrel Versus Aspirin MOnotherapy After 1- to 3-month of Dual-antiplatelet thErapy Following Zotarolimus-eluting Onyx Stents Implantation; C-MODE Trial
Previous randomized clinical trials have deomonstrated the efficacy and safety of short-term dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI), however, the single antiplatelet agent to be maintained…
- Trial name
- NCT05320926
- Testing
- Clopidogrel monotherapy, Aspirin monotherapy, zotarolimus-eluting stent (Resolute Onyx ®)
- Where
- South Korea
- Volunteers
- 3,744 people
- Sponsor
- Yonsei University
Bile Duct Obstruction, Extrahepatic Cholestasis
Primary Versus Secondary Metal Stent Implantation in PTBD
The aim is to compare percutaneous transhepatic biliary drainage (PTBD) with primary metal stent implantation (one stage-procedure) with PTBD with secondary metal stent implantation in terms of adverse events.
- Trial name
- NCT04992585
- Testing
- Percutaneous transhepatic implantation of self-expandable metal stent
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Coronary Artery Disease
Thalidomide fOr the Prevention of Restenosis After Coronary ArtERy Stent Implantation
Percutaneous coronary intervention (PCI) with the use of bare metal stents is associated with restenosis in approximately 10% to 50% of cases.
- Trial name
- TOP RACER (NCT01638078)
- Testing
- Thalidomide
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
FFR Versus IVUS With Angiography-Derived FFR for Clinical Outcomes in Patients With Coronary Artery Disease
To compare the clinical outcomes of fractional flow reserve (FFR)-guided strategy versus intravascular ultrasound (IVUS)-guided stent implantation after angiography-derived FFR-based decision-making.
- Trial name
- FLAVOUR III (NCT06218485)
- Testing
- Intravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making, Fractional flow reserve-guided PCI strategy
- Where
- 32 sites in China, South Korea
- Volunteers
- 1,942 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Remote Ischemic Conditioning
Effect of RIC on Cerebral Autoregulation in Patients Undergoing Cerebrovascular Stent Implantation
The purpose of this study is to determine the effect of remote ischemic conditioning on cerebral autoregulation in patients undergoing cerebrovascular stent implantation.
- Trial name
- NCT05970653
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Yi Yang
Pulmonary Disease, Chronic Obstructive
Evaluating the Clinical Effectiveness of a Patient-specific Silicone Stent
The goal of the trial is to establish a method, material, and patient-specific stent design that will last longer, fit better, and cause less trauma to the airway and the patient.
- Trial name
- NCT05050591
- Testing
- Patient-Specific Silicone Airway Stent
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- VisionAir Solutions
In Stent Restenosis
Focal In-stent Restenosis After Drug-Eluting Stent
To evaluate the optimal management of focal in-stent restenosis after drug-eluting stent implantation with sirolimus-eluting implantation versus cutting balloon angioplasty
- Trial name
- FOCUS (NCT00485004)
- Testing
- Cutting balloon, Sirolimus-eluting stent
- Where
- 15 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Seung-Jung Park