Clinical trials: Steroid
Painful Diabetic Peripheral Neuropathy
Effect Of Pregabalin Treatment In Patients With Diabetic Nerve Pain Who Currently Use A Non-Steroid Anti-Inflammatory Drug (NSAID) For Another Pain
This study is to test the effectiveness of pregabalin in treating nerve pain caused by diabetes. The suitable subjects will be patients who also use an non-steroid anti-inflammatory drug for another pain which is not related to…
- Trial name
- NCT01455415
- Testing
- pregabalin
- Where
- 61 sites in United States, Czechia and 2 more
- Volunteers
- 306 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis, Knee, Osteoarthritis, Hip
Radiofrequency Ablation and Steroid Versus Steroid Alone for Relief of Pain in Patients With Advanced Knee and Hip Osteoarthritis
The purpose of this trial is to determine if radiofrequency ablation plus steroid perineural injections at the knee or hip provide longer pain relief and better function to patients than the current standard of care, perineural…
- Trial name
- NCT05490355
- Testing
- Radiofrequency Ablation (RFA), Perineural Steroid Injection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Texas Southwestern Medical Center
Suicidal Ideation
Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach
Female suicide attempts occur more often in the weeks before and after menses onset, and have been linked to ovarian hormone withdrawal.
- Trial name
- CLEAR-3 (NCT04112368)
- Testing
- Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone 200mg, Inactive Clear Patch
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Illinois Chicago
Smith-Lemli-Opitz Syndrome
Smith-Lemli-Opitz Syndrome and Cholic Acid
The purpose of this study is to determine whether dietary cholic acid therapy benefits people with Smith-Lemli-Opitz syndrome (SLOS) by leading to an increase in plasma cholesterol and reduction in harmful cholesterol precursors.
- Trial name
- NCT03720990
- Testing
- Cholic Acid
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Nebraska
Uveitis Related Cystoid Macular Edema, Steroid-induced Glaucoma - Borderline
The LIMO Study, Lucentis for Treatment of Uveitic Patients With Refractory Cystoid Macular Oedema
Anti-vascular endothelial growth factor (VEGF) treatments show great promise in the treatment of a variety of retinal diseases. This study addresses a condition which affects a large number of our patients in whom the…
- Trial name
- NCT01564108
- Testing
- Ranibizumab
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Immune Thrombocytopenia
The Combination of Tacrolimus and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
Randomized, open-label, multicenter study to compare the efficacy and safety of combination of tacrolimus and danazol versus danazol for the treatment of adults with steroid-resistant/relapse immune thrombocytopenia (ITP).
- Trial name
- NCT05471050
- Testing
- TAC, Danazol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Focal Segmental Glomerulosclerosis
Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis
This study will investigate whether RE-021 (Sparsentan), a selective dual-acting receptor antagonist with affinity for endothelin (A type) and angiotensin II receptors (Type 1), is safe and effective in treating patients with…
- Trial name
- DUET (NCT01613118)
- Testing
- RE-021 (Sparsentan), Irbesartan
- Where
- 33 sites in United States, Czechia and 1 more
- Volunteers
- 109 people
- Sponsor
- Travere Therapeutics, Inc.
Kidney Diseases
Steroid Withdrawal in Pediatric Renal Transplant: Impact on Growth, Bone Metabolism and Acute Rejection
The present study investigates the safety and efficacy of steroid withdrawal at six days post-transplant in pediatric renal recipients under concomitant immunosuppression based on antibodies anti IL2 (interleukin 2), Tacrolimus…
- Trial name
- NCT00707759
- Testing
- Tacrolimus (TAC)+ Mycophenolate Mofetil (MMF) + Withdrawal Prednisone, Tacrolimus (TAC)+ Mycophenolate Mofetil (MMF) + prednisolone
- Where
- Chile
- Volunteers
- 28 people
- Sponsor
- Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
End Stage Renal Disease, Kidney Transplantation
Efficacy of Sirolimus-Based, Steroid Avoidance Immunosuppression African Americans
African Americans receiving a kidney transplant are considered at high risk for early rejection of their transplanted kidney and require more immunosuppression to maintain their kidney transplant function.
- Trial name
- NCT00189202
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Michigan
Lumbar Spinal Stenosis
Erector Spinae Plane vs Caudal Epidural Steroid in Lumbar Spinal Stenosis Resistant to Conservative Therapy
Lumbar spinal stenosis is a common cause of neurogenic claudication and functional limitation in older adults. Epidural steroid injections are frequently used in patients who do not respond to conservative treatments.
- Trial name
- NCT07445477
- Testing
- Erector Spinae Plane Block, caudal epidural steroid injection
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hatice Çetintürk Şahin
Nasal Polyps
Mepolizumab in Nasal Polyposis
A two-part, randomised, double-blind, placebo controlled, multi-centre study to investigate the use of mepolizumab (SB-240563) in reducing the need for surgery in subjects with severe bilateral nasal polyposis.
- Trial name
- NCT01362244
- Testing
- Mepolizumab, Run In Medication
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 109 people
- Sponsor
- GlaxoSmithKline
Chronic Neck Pain, Radicular Pain
Reliability of MRI and Ultrasound in Cervical Epidural Needle Depth Estimation
This study aims to evaluate the reliability of magnetic resonance imaging (MRI) and ultrasound (USG) in predicting needle depth during cervical epidural injections, compared to fluoroscopy.
- Conditions
- Chronic Neck Pain, Radicular Pain, Cervical Epidural Injection
- Trial name
- CERV-MRI-USG (NCT06747663)
- Testing
- Needle Depth Measurement Using MRI, Ultrasound, and Fluoroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Damla Yürük
Mycoplasma Pneumoniae Pneumonia
Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia
Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in children. The clinical course is typically self-limited and benign; however, rare cases of severe pneumonia can develop despite appropriate…
- Trial name
- NCT02618057
- Testing
- Prednisolone, Levofloxacin
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Pain, Neuropathic
Can Dexmedetomidine With Hyalase Augment Quality and Duration of Analgesia When Added to Lumbar Epidural Steroid in Failed Back Surgery. Randomized Double Blind Study
use of dexmedtemodine to augment analgesia in cases of failed back surgery
- Trial name
- NCT05349448
- Testing
- Hylase plus Triamcinolone plus sterile isotonic saline, Hylase plus Dexmedetomidine plus Triamcinolone
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Adrenal Hyperplasia, Polycystic Ovarian Syndrome
Adrenal Hyperplasia Among Young People With PCOS
Background: Polycystic ovarian syndrome (PCOS) is a group of disorders related to problems with the secretion of certain hormones, which can lead to reproductive and other issues in women.
- Conditions
- Adrenal Hyperplasia, Polycystic Ovarian Syndrome, Oligomenorrhea, Obesity
- Trial name
- NCT01313455
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Glomerulonephritis, Membranous
Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy
Idiopathic Membranous nephropathy (IMN) is an auto-immune glomerular disease. Recent studies suggest that circulating auto-antibodies against the podocyte surface antigens phospholipase A2 receptor1 (PLA2R1) and thrombospondin…
- Trial name
- RI-CYCLO (NCT03018535)
- Testing
- Rituximab, Methylprednisolone, Cyclophosphamide
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Chronic Graft-versus-host-disease
Efficacy and Safety of SCM-CGH in Patients With Steroid-Refractory or Dependent Chronic Graft-Versus-Host Disease
The purpose of this study is to evaluate efficacy of SCM-CGH in participants with steroid dependent/refractory chronic graft versus host disease (cGVHD) by measuring overall cGVHD response (complete response [CR] and partial…
- Trial name
- NCT04189432
- Testing
- SCM-CGH
- Where
- 11 sites in South Korea
- Volunteers
- 84 people
- Sponsor
- SCM Lifescience Co., LTD.
Acute Graft Versus Host Disease
Combination of Steroid and Humanized CD25 Monoclonal Antibody as First-line Therapy for aGVHD
The first-line treatment of acute graft-versus-host disease with humanized CD25 monoclonal antibody combined with glucocorticoid was used to study the remission rate of acute graft-versus-host disease, the cumulative incidence…
- Trial name
- NCT06473909
- Testing
- CD25 antibody combined glucocorticoid as first-line treatment
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Advanced Breast Cancer
Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Metastatic or Locally Advanced Breast Cancer
Open-label, Phase II study of Stomatitis prevention with a steroid-based mouthwash in Post-menopausal women with ER+, HER2- Metastatic or Locally Advanced Breast Cancer
- Trial name
- NCT02069093
- Testing
- Dexamethasone based mouthwash, Everolimus, Exemestane
- Where
- 23 sites in United States
- Volunteers
- 92 people
- Sponsor
- Novartis Pharmaceuticals
Purpura, Idiopathic Thrombocytopenic Purpura
Recombinant Human Thrombopoietin in Combination With Rituximab in Immune Thrombocytopenia (ITP)
The purpose of this study is to determine whether Recombinant Human Thrombopoietin (rh-TPO) in combination with Rituximab are effective and safe in the management of Steroid-Resistant/Relapsed Immune Thrombocytopenia (ITP).
- Trial name
- NCT01506414
- Testing
- rhTPO in combination with Rituximab
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Ming Hou
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