Clinical trials: Steroid
Chronic Sinusitis, Rhinosinusitis
Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study
This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis.
- Conditions
- Chronic Sinusitis, Rhinosinusitis, Nasal Polyps
- Trial name
- NCT00841802
- Testing
- Prednisone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Gender Dysphoria
Cross-sex Hormone Therapy and Neuronal Plasticity
Transgender women (male-to-female) were invited to participate in this study to test the impact of Cross-Sex Hormone Therapy (CSHT) in the brain.
- Trial name
- NCT03651427
- Testing
- Estradiol
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Voice Change, Hypocalcemia
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong.
- Trial name
- NCT05732883
- Testing
- Dexamethasone, Normal saline
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tseung Kwan O Hospital, Hong Kong
Graft Versus Host Disease
A Phase 2/3 Study of GLASSIA for the Treatment of Acute GvHD
The purpose of the study is to evaluate the safety and efficacy of GLASSIA as an add-on biopharmacotherapy to standard-of-care steroid treatment as the first-line treatment in participants with acute GvHD with lower GI…
- Trial name
- NCT02956122
- Testing
- GLASSIA, methylprednisolone or equivalent steroid, Albumin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baxalta now part of Shire
Adrenal Hyperplasia, Congenital
Research Study for Children With Salt Wasting Congenital Adrenal Hyperplasia
The purpose of this study is to develop a more physiological approach to the management of children and adolescents with salt wasting Congenital Adrenal Hyperplasia.
- Trial name
- NCT00529841
- Testing
- Hydrocortisone sodium acetate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor College of Medicine
Congenital Adrenal Hyperplasia
Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement Therapy
This study is an open-label, randomised, titration-blinded, parallel arm, multicenter study to compare twice daily Chronocort® with standard care in participants with Congenital Adrenal Hyperplasia (CAH).
- Trial name
- RESTORE (NCT03532022)
- Testing
- Chronocort®, Standard Care
- Where
- United States
- Sponsor
- Neurocrine UK Limited
HEPATITIS
TO Compare the Triple Drug Therapy and Dual Therapy .
Study to Compare the Safety and Efficacy of Tacrolimus and Steroids in Combination With Mycophenolate Mofetil or Without Mycophenolate Mofetil in Liver Transplantation with Hepatitis B Virus(HBsAg) Positive
- Trial name
- OPTIMUS-A (NCT02075242)
- Testing
- Mycophenolate Mofetil, Tacrolimus
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Asan Medical Center
Cerebral Venous Thrombosis
Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis.
The cohort study aims to evaluate the efficacy and safety of steroids combined with anticoagulant therapy compared to standard anticoagulant therapy in acute/subacute severe cerebral venous thrombosis.
- Trial name
- NCT05990894
- Testing
- Methylprednisolone
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Xuanwu Hospital, Beijing
Nephrotic Syndrome in Children, Minimal Change Disease
A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)
Children with steroid resistant nephrotic syndrome (SRNS) are exposed to prolonged courses of immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent…
- Conditions
- Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
- Trial name
- kidNEY-VNS (NCT05583942)
- Testing
- trascutaneous auricular vagus nerve stimulation
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Lumbar Disc Disease, Lumbar Spine Degeneration
The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)
The primary objective is to determine the validity of the Six-Minute-Walking Test (6WT) and Timed-Up and Go (TUG) test to measure objective functional impairment (OFI) in patients undergoing either interlaminar epidural steroid…
- Conditions
- Lumbar Disc Disease, Lumbar Spine Degeneration, Lumbar Spinal Stenosis
- Trial name
- NCT04062942
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Abuse of Anabolic Steroids
Intranasal Delivery of Testosterone and Its Effect on Doping Markers
Hypothesis: Intranasal administration of exogenous testosterone results in a characteristic profile during anti-doping testing, which is different than the profile seen when testosterone is administered into muscle, on skin or…
- Trial name
- Intranasal (NCT02611154)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Utah
Autoimmune Hepatitis, Autoimmune Liver Disease
PredIcting sterOid depeNdEnt livEr injuRy With Polyreactive Immunoglobulin G
The investigators identified polyreactive immunoglobulin G (pIgG) in adults (published in Hepatology: https://doi.org/10.1002/hep.32134) and children (in preparation).
- Trial name
- PIONEER (NCT05810480)
- Testing
- polyreactive immunoglobulin G
- Where
- 6 sites in Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Knee Osteoarthritis
Radiofrequency Ablation in the Pain Management of Knee Osteoarthritis
The aim of this study is to assess the safety and efficacy of radio frequency thermo-coagulation on the genicular nerve (RFTGN) and intra-articular pulsed radio frequency (IAPRF) for Knee Osteoarthritis (KOA) to improve physical…
- Trial name
- NCT05303766
- Testing
- Radio-frequency ablation, Intra-articular steroids, Pulsed Radio-frequency
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Congenital Adrenal Hyperplasia
A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH
Subjects completing study DIUR-005 and those who have already completed study DIUR-003 will be offered the opportunity either to continue Chronocort® therapy or to switch from their current glucocorticoid therapy to Chronocort®…
- Trial name
- NCT03062280
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Neurocrine UK Limited
Congenital Adrenal Hyperplasia, CAH - Congenital Adrenal Hyperplasia
Study to Evaluate the Safety and Efficacy of SPR001 in Subjects With Classic Congenital Adrenal Hyperplasia
This is a Phase 2 study of SPR001 for the treatment of classic CAH that will provide 12 weeks of open-label treatment to eligible subjects.
- Conditions
- Congenital Adrenal Hyperplasia, CAH - Congenital Adrenal Hyperplasia, CAH - 21-Hydroxylase Deficiency
- Trial name
- NCT03687242
- Testing
- SPR001
- Where
- 8 sites in United States
- Volunteers
- 11 people
- Sponsor
- Spruce Biosciences
Alopecia Areata
Sodium Valproate-loaded Nanospanlastics in Patchy Alopecia Areata in Comparison to Topical Steroids
the aim of this study is to assess the efficacy and safety of sodium valproate-loaded nanospanlastic in the treatment of patchy AA, in comparison to conventional therapy with topical steroids
- Trial name
- NCT05017454
- Testing
- the optimized sodium valproate-loaded nanospanlastic dispersion, mometasone furoate lotion
- Where
- Egypt
- Volunteers
- 67 people
- Sponsor
- Kasr El Aini Hospital
Eosinophilic Esophagitis
Topical Steroid Treatment for Eosinophilic Esophagitis
This was a randomized controlled trial of swallowed fluticasone vs. placebo for eosinophilic esophagitis. Eosinophilic esophagitis is an inflammatory condition in which the wall of the esophagus becomes filled with large numbers…
- Trial name
- NCT00275561
- Testing
- Fluticasone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Mayo Clinic
Asthma
Steroid Titration Against Mannitol IN Asthma
The investigators hypothesise that titration of asthma medication against mannitol challenge results will reduce the number of mild asthma exacerbations, in one year, when compared with titration against BTS guidelines.
- Trial name
- NCT01216579
- Testing
- mannitol (an airway challenge agent)
- Volunteers
- 164 people
- Sponsor
- University of Dundee
Radiation-Induced Mucositis
Steroid-Eluting Stent Implant for the Treatment of Radiation-Related Sinusitis
Sinusitis is one of the most common sequelae after radiotherapy among nasopharyngeal carcinoma patients. While local steroids have been shown to be effective in the management of patients with chronic rhinosinusitis, their role…
- Trial name
- NCT05757479
- Testing
- Steroid-eluting stent implantation, Steroid nasal spray, nasal saline rinses
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Sun Yat-sen University
Adhesive Capsulitis
Effects of Intra-articular Versus Subacromial Steroid Injections on Clinical Outcomes in Adhesive Capsulitis
The primary objective is to compare the clinical outcomes of patients with a clinical diagnosis of Adhesive Capsulitis who receive intra-articular versus subacromial steroid injections.
- Trial name
- NCT00742846
- Testing
- Lidocaine + Kenalog, Lidocaine
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
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