Clinical trials: Steroid-Induced Diabetes
Steroid-Induced Diabetes, Diabete Type 2
Predictive Factors and Monitoring Strategies in Steroid-Induced Diabetes
Glucocorticoids are widely used in the management of autoimmune, inflammatory and neoplastic conditions. However, they are associated with significant metabolic effects, including steroid-induced diabetes (SID).
- Conditions
- Steroid-Induced Diabetes, Diabete Type 2, Steroid Induced Hyperglycemia
- Trial name
- NCT07190378
- Where
- Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus
Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes
Steroid injections used to treat painful joints can temporarily increase glucose levels in people with type 2 diabetes. This study will test whether a short course of pre-emptive neutral protamine Hagedorn, NPH, insulin can…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus, Osteoarthritis, Knee
- Trial name
- PREVENT-SIH (NCT07757464)
- Testing
- Insulin Isophane Human, NPH, Pre-emptive Algorithm, Triamcinolone Acetonide Knee Injection
- Where
- Pakistan
- Volunteers
- 125 people
- Sponsor
- Shifa International Hospital
Acute Graft Rejection, Diabetes
A Pilot Study Comparing the Use of Low-target Versus Conventional Target Advagraf
While the incidence of acute rejection and early graft loss have improved dramatically with the advent of newer immunosuppressant medications, improvements in long-term patient and allograft survival after kidney transplantation…
- Trial name
- Astellas (NCT01265537)
- Testing
- Tacrolimus
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Diabetic Patient (Type 1,2, MODY, Secondary) or With Corticosteroid-induced Diabetes Following Initiation of Corticosteroid Treatment
Tele-expertise in Patients With Diabetes Hospitalized for Covid-19 Infection
Diabetes is a major factor of morbi-mortality in Covid-19 infection. Currently, steroid therapy is required in patients under oxygen therapy. This treatment is associated with hyper glycaemia in patients with diabetes.
- Trial name
- COVIDEX (NCT04726163)
- Testing
- Continuous blind glucose measurement device (Free style Pro)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Strasbourg, France
Steroid-Induced Diabetes, Steroid Induced Hyperglycemia
The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes
TITLE: How GLP-1 Analogues prevent steroid-induced diabetes (The GAPSID Study) DESIGN: A double-blind study evaluating how GLP-1 analogues, compared with metformin, prevent hyperglycaemia in response to a 7-day course of…
- Trial name
- NCT06318442
- Testing
- Semaglutide Oral Product, Metformin Oral Tablet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes, Immunosuppression
Evaluate Tolerability of Myfortic®/Simulect® and Tacrolimus Without Steroids in Three Patient Populations
This study is designed to evaluate the tolerability of Myfortic®/Simulect® combination in diabetic patients in a steroid free regimen.
- Trial name
- NCT01387659
- Testing
- Gastric emptying test
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetes, Hyperglycemia Steroid-induced
Effect of Short Course of Glucocorticoid in Patients With Diabetes Mellitus(DM) Type 2
Participants will receive prednisone 40 mg for 3 days. 75 g oral glucose tolerance test (OGTT), insulin and C-peptide will be measured on day 1 (before prednisone) and day 3 (after prednisone).
- Trial name
- NCT03661684
- Testing
- Prednisone
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cook County Health
Diabetes, Knee Osteoarthritis
Knee Steroid Injection and Blood Sugar Signatur
A prospective, observational study assessing the relationship between HbA1c level and the post-injection blood glucose signature.
- Trial name
- NCT04317404
- Testing
- 40 mg Triamcinolone acetonide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 1, Diabetic Nephropathy
European Trial of Immunosuppression in SPK Tx
1. To determine and compare the efficacy of Tacrolimus/Rapa versus Tacrolimus/MMF-based immunosuppression (in conjunction with initial short-term steroids and polyclonal antibody administration) in Type 1-diabetic patients…
- Trial name
- NCT00140543
- Testing
- sirolimus versus mycophenolate mofetil
- Where
- 14 sites in Austria, Belgium and 5 more
- Volunteers
- 228 people
- Sponsor
- EUROSPK Study Group
Diabetes, Pain Management
CGM as Diagnostic Tool in Observing Steroid-Induced Hyperglycemia
This study is designed to help understand how certain steroid medications affect blood sugar levels in patients undergoing pain management treatments.
- Trial name
- TRC-DX-1 (NCT06628284)
- Testing
- Dexcom G7
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mahesh Pattabiraman
System; Lupus Erythematosus
Steroid-induced Diabetes Mellitus in Systemic Lupus Erythematosus (SLE) Patients
The aim of the study is to determine the prevalence of steroid-induced diabetes mellitus (SDM) among systemic lupus erythematosus (SLE) patients and identify and assess the associated risk factors .
- Trial name
- NCT04024306
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Chronic Rhinosinusitis Without Nasal Polyps, Asthma
Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis
The purpose of this study is to investigate the relationship between long-term use of systemic steroids in patients with upper and lower respiratory tract diseases and their own production of cortisol (cross-sectional), as well…
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps, Asthma, Chronic Rhinosinusitis With Nasal Polyps, Steroid-Induced Osteopenia (Diagnosis)
- Trial name
- AGAS 2023 (NCT05843019)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Christiane Haase
Pre-diabetes, Impaired Fasting Glucose
Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy
The investigators hypothesize that sitagliptin will significantly reduce impairments in insulin secretion and insulin resistance resulting from short-term oral glucocorticoid therapy.
- Conditions
- Pre-diabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT01488279
- Testing
- Dexamethasone 2.5 mg and Sitagliptin 100 mg
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Breast Cancer, Pancreatic Cancer
Glucose Monitoring to Predict and Treat High Glucose Levels After Steroid Treatment
The purpose of this study is to see if continuous glucose monitoring can identify how often people who have pre-diabetes or medical obesity or well-controlled diabetes experience very high glucose values while receiving…
- Conditions
- Breast Cancer, Pancreatic Cancer, Diabetes, Pre Diabetes
- Trial name
- NCT04210128
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Diabetes Mellitus
Trial of Steroid Avoidance and Low-dose CNI by ATG-induction in Renal Transplantation
Balancing immunosuppressive treatment in organ transplantation in order to achieve effective prevention of rejection on one side and avoidance of negative side effects on the other side is a major challenge, leading to developing…
- Trial name
- SAILOR (NCT02083991)
- Testing
- Steroid-free low TAC-arm: Thymoglobulin Standard low-TAC arm: Simulect, prednisolon
- Where
- Sweden
- Volunteers
- 224 people
- Sponsor
- Vastra Gotaland Region
Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes
Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
Glucocorticoids are known to cause an increase in insulin resistance, leading to hyperglycemia, in both diabetic and non-diabetic patients.
- Trial name
- NCT03511521
- Testing
- NPH Insulin, glargine, Insulin Aspart
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Lymphoma, Diabetes Mellitus, Type 2
Validation of Insulin Protocol for Glucocorticoid-induced Hyperglycemia in Diabetic Oncology Patients
There are no guidelines for the management of glucocorticoid- (henceforth steroid) induced elevated blood sugars (henceforth hyperglycemia).
- Conditions
- Lymphoma, Diabetes Mellitus, Type 2, Hyperglycemia
- Trial name
- NCT02012465
- Testing
- Insulin protocol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
Diabetes Mellitus, Steroid Diabetes
Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism in Males With the Metabolic Syndrome
The investigators will assess whether the DPP-inhibitor sitagliptin will ameliorate glucocorticoid-induced impairment of glucose metabolism and beta-cell dysfunction and thus could be used as a prophylaxis for…
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Glucocorticoid-induced Diabetes, Beta-cell Function
- Trial name
- SPHINX (NCT00721552)
- Testing
- Sitagliptin 100 mg, Prednisolone 30 mg
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Type 2 Diabetes, Steroid-induced Diabetes
CGM After Discharge From Hospital
This is an investigator initiated prospective, randomized controlled trial which aims to compare two groups of patients with either type 2 or steroid-induced diabetes who are discharged with insulin.
- Trial name
- NCT07510386
- Testing
- Libre 3 Plus continuous glucose monitoring (CGM) system, Blinded Continuous Glucose Monitoring, Finger stick
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai