Clinical trials: Stiffness, Vascular
Venous Thromboembolism
Thrombus Elastography in Venous Thrombo-Embolism.
Venous Thrombo-Embolic Disease (VTED) is a serious and common ailment, defined by the growth of a clot - or thrombus - in a vein, and/or as the migration of this thrombus to a pulmonary artery.
- Trial name
- TEVTE (NCT04130048)
- Testing
- Ultrasound Elastography
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Brest
Diabetes Mellitus
Vascular Markers During OGTT in Diabetics and First-degree Relatives
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT02244736
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Athens
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension
LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)
The primary objective of this study is to evaluate efficacy, arterial stiffness measured by Pulse Wave Velocity (PWV) of Losartan potassium group compared to Carvedilol group after 24 weeks of treatment in patients with the…
- Trial name
- NCT00496834
- Testing
- losartan potassium, Comparator: carvedilol, Comparator: losartan (+) hydrochlorothiazide (HCTZ)
- Volunteers
- 201 people
- Sponsor
- Organon and Co
Ageing, Blood Flow Restriction (BFR) Training Effects
Comparing Vascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults
Aging is a major risk factor for cardiovascular disease (CVD), contributing to progressive macrovascular and microvascular dysfunction.
- Trial name
- UNDER PRESSURE (NCT07079280)
- Testing
- Low Intensity Aerobic Exercise with Blood Flow Restriction (LIAE+BFR), High Intensity Interval Exercise (HIIE)
- Where
- Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Lv Hypertrophy, Heart Failure, Diastolic
Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for one year in sedentary middle aged (ages 40-64) individuals at high risk for future development of heart failure will improve cardiac…
- Conditions
- Lv Hypertrophy, Heart Failure, Diastolic, Stiffness, Vascular
- Trial name
- LVH (NCT03476785)
- Testing
- High intensity exercise, Yoga
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension
A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension
This was the first evaluation of the effects of LCZ696 on local and regional measures of aortic stiffness in subjects with mild to moderate hypertension and widened pulse pressure.
- Trial name
- NCT01870739
- Testing
- sacubitril/valsartan (LCZ696), olmesartan, Amlodipine (Optional)
- Where
- 4 sites in Germany, Switzerland and 1 more
- Volunteers
- 115 people
- Sponsor
- Novartis Pharmaceuticals
Transfemoral tranScatheter Aortic valvE Implantation
Ultrasound arteriaL Stiffness evaluatIon and vaScular Complications in Patients Undergoing Transfemoral tranScatheter Aortic valvE Implantation: ULISSE Study.
Transcatheter aortic valve implantation (TAVI) is an established treatment modality in patients ≥ 75 years old with severe symptomatic aortic stenosis after Heart Team evaluation (1).
- Trial name
- ULISSE (NCT05468762)
- Testing
- Transfemoral tranScatheter aortic valvE implantation
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Dr. Giuseppe Musumeci
Hypertension, Systolic, Stiffness, Aortic
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke.
- Trial name
- SELECT (NCT04423627)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Obesity, Vascular Risk
Efficacy of Triticum Aestivum Over Vascular Function in Mexican Obese Patients
This study aims to evaluate the efficacy of Triticum aestivum as a treatment for improving the vascular function in Mexican obese patients.
- Trial name
- NCT06950138
- Testing
- Triticum aestivum, calcined magnesia
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Hypertension
Efficacy of fimaSartan on arTerIal stiFFness iN patiEntS With HypertenSion
The purpose of this study is to evaluate the effects of fimasartan on arterial stiffness in patients with hypertension
- Trial name
- STIFFNESS (NCT02022774)
- Testing
- Fimasartan
- Where
- 7 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Blood Vessel Disease, Muscle Edema
The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs
The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.
- Trial name
- NCT06276673
- Testing
- Delfi
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Salisbury University
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Endothelial Dysfunction, Vascular Stiffness
Sodium Lowering Vascular Effects Trial
The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension.
- Conditions
- Endothelial Dysfunction, Vascular Stiffness, Left Ventricular Hypertrophy, Left Ventricular Dysfunction
- Trial name
- SOLVE (NCT05388032)
- Testing
- Sodium Reduction Intervention
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Tulane University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Peanuts for Cardiometabolic, Brain, and Intestinal Health
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function
- Trial name
- NCT06867198
- Testing
- Peanuts
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Georgia State University
Acute Coronary Syndrome
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
To investigate pleiotropic effects of ticagrelor in addition to its antiplatelet effects in type 2 diabetic patients with non-ST elevation acute coronary syndrome by measuring inflammatory markers, circulating number of…
- Trial name
- NCT02487732
- Testing
- Ticagrelor, Prasugrel
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Obesity, Pre-hypertension
Low-intensity Resistance Exercise and Diet on Arterial Function and Blood Pressure
Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01371370
- Testing
- Resistance exercise training, Hypocaloric diet, Resistance exercise training & diet
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Florida State University
Hypertension
Oral Cannabidiol Effect on Blood Pressure in Hypertensive Patients
The objective of this randomized, placebo-controlled and crossover study is to extend the findings from the acute studies into more chronic administration of CBD in individuals with mild or moderate hypertension who are either…
- Trial name
- HYPER-H21-4 (NCT05346562)
- Testing
- Cannabidiol
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- University of Split, School of Medicine