Clinical trials: Stimulant Abuse
Attention Deficit Disorder With Hyperactivity, Conduct Disorder
Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder
Childhood ADHD and comorbid oppositional defiant disorder (ODD) and conduct disorder (CD) are considered risk factors for subsequent substance abuse, and youth with both ADHD and ODD/CD are at greatest risk.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Conduct Disorder, Substance Abuse
- Trial name
- NCT04170738
- Testing
- Adderall
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Jeffrey Newcorn
Alcohol Abuse, Cannabis Abuse
Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse
The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
- Trial name
- NCT00108407
- Testing
- Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Methamphetamine Abuse, Substance Use Disorders
rTMS for Craving in Methamphetamine Use Disorder
The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced craving in adult methamphetamine…
- Conditions
- Methamphetamine Abuse, Substance Use Disorders, Stimulant Dependence, Methamphetamine-dependence
- Trial name
- NCT03470480
- Testing
- Real Repetitive transcranial magnetic stimulation, Methamphetamine visual cues, Neutral visual cues
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Drug Abuse
Stimulant Abuser Groups to Engage in 12-Step
The purpose of this study is to determine whether a combined group and individual 12-Step facilitative (TSF) intervention, Stimulant Abuser Groups to Engage in 12 -Step (STAGE-12), improves substance -related outcomes.
- Trial name
- STAGE-12 (NCT00573183)
- Testing
- STAGE-12, Treatment as Usual
- Where
- 10 sites in United States
- Volunteers
- 471 people
- Sponsor
- University of Washington
Prescription Drug Abuse (Not Dependent), Intentional Misuse
Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation Intervention
Half or nearly half of college students with prescriptions divert their stimulant medication, and a similarly high percentage misuse their medication or use someone else's prescription.
- Trial name
- NCT04885166
- Testing
- Web-based simulation active intervention
- Where
- 3 sites in United States
- Volunteers
- 249 people
- Sponsor
- Trinity College
Cognitive Dysfunction, Stimulant Use
Change in Cognitive Function in Stimulant Users
In Hong Kong, methamphetamine use is common and cocaine use has increased steadily over the past few years. While the use of ketamine decreased from 35.8% in 2015 to 13.9% in 2017, methamphetamine and cocaine have become the most…
- Conditions
- Cognitive Dysfunction, Stimulant Use, Methamphetamine Abuse, Cocaine Use
- Trial name
- SToP-S_CogFx (NCT04061941)
- Testing
- Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 93 people
- Sponsor
- The University of Hong Kong
HIV, Drug Addiction
Treating South African Pregnant Women for Methamphetamine
The purpose of this study was to develop and initially evaluate an efficacious, comprehensive, culturally sensitive, women-centered model of care for pregnant South African women by adapting and refining PI Jones'…
- Trial name
- NCT01386138
- Testing
- Psycho-education, Experimental
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- RTI International
Methamphetamine-dependence, Substance Abuse
Safety Interaction Trial Ibudilast and Methamphetamine
This study is designed to collect data to determine whether a medication, ibudilast, is safe for use as a potential treatment for methamphetamine-dependent people.
- Trial name
- NCT01217970
- Testing
- Ibudilast 20mg, Ibudilast 50mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Cocaine Dependence
New Medication Treatment for Stimulant Dependence
This study will evaluate the efficacy of ondansetron compared with placebo in the treatment of cocaine dependence.
- Trial name
- NCT00689572
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
ADHD, Stimulant-Induced Euphoria
Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist
The purpose of this study is to a) assess the efficacy of naltrexone in preventing stimulant-induced euphoria in adults with ADHD, b) assess whether naltrexone will interfere with the clinical efficacy of stimulants in treating…
- Trial name
- NCT01673594
- Testing
- SODAS MPH, Naltrexone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Stimulant Abuse and Dependence
Exercise as a Treatment for Substance Use Disorders Protocol
The purpose of this study is to investigate if health interventions (intensive exercise or health education) can be used to help improve substance abuse treatment.
- Trial name
- STRIDE (NCT01141608)
- Testing
- Vigorous Intensity High Dose Exercise, Health Education Intervention
- Where
- 9 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy, Drug Abuse
Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users
The purpose of this study is to assess the abuse potential of single doses of pitolisant relative to phentermine HCl and placebo, when administered to healthy, non-dependent, recreational stimulant users.
- Trial name
- NCT03152123
- Testing
- Pitolisant, Phentermine
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bioprojet
ADHD, Attention Deficit Hyperactivity Disorder
Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems…
- Trial name
- MPH-ATX (NCT03781765)
- Testing
- Methylphenidate, Atomoxetine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Naltrexone, Methylphenidate Abuse
Study for Naltrexone on the Abuse Potential of Methylphenidate
The current abuse liability study aims to assess the potential for co-administration of naltrexone (NTX) to reduce the abuse potential of methylphenidate (MPH).
- Trial name
- NCT03769064
- Testing
- Methylphenidate 60 mg, Treatment Phase Sequence 4213, Treatment Phase Sequence 2134
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Avekshan LLC
Substance Abuse
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
This placebo-controlled, double-blind, randomized pilot clinical trial will evaluate atomoxetine (Strattera®) for the treatment of cocaine dependence.
- Trial name
- NCT00617201
- Testing
- atomoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Psychoactive Substances Consumption, Substance-related Disorder
French Study on COgnitive Enhancement and Consumption of Psychoactive Substances Among Youth Students
This descriptive and declarative study will help to find out consumption rates, all psychoactive substances taken together, among 18-25 year olds.
- Conditions
- Psychoactive Substances Consumption, Substance-related Disorder, Off Label-use, Cognitive Enhancement
- Trial name
- ENQUETE-COSYS (NCT02954679)
- Testing
- Online self-administrated and anonymous survey questionnaire
- Where
- France
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections, Methamphetamine-dependence
Stimulant Use and Methylation in HIV
This study will leverage extracted leukocyte DNA specimens from a completed NIH-funded project to examine the efficacy of a behavioral intervention model that reduced stimulant use on DNA methylation over 6 months.
- Conditions
- HIV Infections, Methamphetamine-dependence, Methamphetamine Abuse
- Trial name
- NCT05916989
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Florida International University
Stimulant Use Disorder
Smartphone Services for Stimulant Use Disorder
This study is testing two approaches to treating Stimulant Use Disorder, or problems with cocaine, crack, methamphetamine, etc. Stimulant Use Disorder is a national epidemic in the U.S.
- Trial name
- NCT07092059
- Testing
- Smartphone digital therapeutic system
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- DynamiCare Health
ADHD, Narcolepsy
Study to Evaluate the Abuse Liability, Pharmacokinetics, Safety and Tolerability of an Abuse-Deterrent d-Amphetamine Sulfate Immediate Release Formulation (ADAIR)
This is a randomized, double-blind, double-dummy, placebo- and active-controlled 4 period, 4 way crossover study to assess the intranasal abuse potential of manipulated ADAIR formulation in nondependent, recreational stimulant…
- Trial name
- SEAL (NCT04647903)
- Testing
- ADAIR 10 mg IR tablets, d-amphetamine sulfate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Vallon Pharmaceuticals, Inc.
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)