Clinical trials: Stimulant Use
Amphetamine-Related Disorders, Tobacco Use Disorder
Effects of Stimulant Dependence on Human Striatal Dopamine System - 15
The purpose of this study is to determine whether DAT availability, assessed by WIN binding, in the striatum is altered in cocaine or methamphetamine dependence.
- Trial name
- NCT00000350
- Testing
- radioactive substance
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Stimulant Use (Diagnosis), Hiv
Contingency Management in HIV Care for Both Stimulant Use & ART Adherence
Methamphetamine use and associated sequelae have been rising, and represent a major barrier to successful control of the HIV epidemic.
- Trial name
- CoMBo (NCT06564792)
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, San Francisco
Stimulant Use, Human Immunodeficiency Virus (HIV)
Project neuroARTEMIS
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave.
- Conditions
- Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
- Trial name
- NCT06814275
- Testing
- ARTEMIS, Contingency management for Antiretroviral (ARV) adherence
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Wake Forest University Health Sciences
Opioid Abuse (Disorder), Stimulant Use Disorders
Optimizing Pregnancy and Treatment Interventions for Moms 3.0
We want to learn if Patient Navigation helps pregnant Medicaid members with opioid use disorder, with or without stimulant use disorder, stay in care, use medications for opioid use disorder, reduce substance use, and connect…
- Trial name
- OPTI-Mom (NCT07586917)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 429 people
- Sponsor
- University of Utah
Addiction, Addiction, Alcohol
The Efficacy of a Mobile Application in Reducing Craving and Lapse Risk in Alcohol and Stimulants Problematic Use
The aim of the study is to evaluate the effectiveness of long-term and short-term app-based self-guided psychological interventions to reduce craving and lapse risk in users with substance use disorder or problematic substance…
- Conditions
- Addiction, Addiction, Alcohol, Addiction, Substance
- Trial name
- NCT05434416
- Testing
- mobile app
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PredictWatch
Substance Use Disorders, Addiction, Alcohol
Evaluating the Effectiveness of Mobile Self-guided Psychological Interventions to Reduce Relapse in Substance Use Disorder
The aim of the study is to evaluate the effectiveness of mobile interventions in reducing craving and lapses in patients diagnosed with Substance Use Disorder.
- Conditions
- Substance Use Disorders, Addiction, Alcohol, Addiction, Substance
- Trial name
- NCT05730504
- Testing
- Mobile app-based self-guided interventions
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- PredictWatch
Stimulant Use, Alcohol Use Disorder
Neuromodulation and Cognitive Training for Substance Use Disorders
The relapsing nature of substance use disorder is a major obstacle to successful treatment. About 70% of those entering treatment will relapse within one year.
- Trial name
- NCT04426214
- Testing
- tDCS, Cognitive Training
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
Nicotine Dependence
Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects
The clinical studies propose to study the abuse-related effects of nicotine after progesterone administration during the follicular phase in women of reproductive age.
- Trial name
- NCT01636336
- Testing
- Nicotine, Progesterone
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in people with HIV who are…
- Trial name
- PRISM (NCT07756736)
- Testing
- Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicky Mehtani, MD, MPH
Stimulant Use
Drugs Brain and Behavior (DDP)
In this project, we will examine individual differences in the effects of a stimulant drug, methamphetamine (MA), on mesolimbic reward function using fMRI.
- Trial name
- DDP (NCT04642820)
- Testing
- Methamphetamine
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Methamphetamine Use Disorder, Substance-Related Disorders
Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder
The purpose of this research study is to investigate the safety and feasibility of two (2) oral doses of psilocybin when combined with behavioral support for methamphetamine use disorder (MUD).
- Conditions
- Methamphetamine Use Disorder, Substance-Related Disorders, Chemically-Induced Disorders, Substance Use Disorders
- Trial name
- NCT05322954
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Wisconsin, Madison
Stimulant Use, Depression
Accelerated rTMS for Substance Use Disorder and Depression
This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder [including methamphetamine or cocaine…
- Trial name
- NCT06424184
- Testing
- Accelerated Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Amphetamine-Related Disorders, Cocaine-Related Disorders
Computerized Exercise to Alter Stimulant Approach Responses
The purpose of this study is to evaluate the Computerized Exercise to Alter Stimulant Approach Responses (CEASAR), a novel stimulant use cessation intervention, for clients currently enrolled in a treatment centre for mental…
- Conditions
- Amphetamine-Related Disorders, Cocaine-Related Disorders, Substance-Related Disorders
- Trial name
- CEASAR (NCT03902405)
- Testing
- Active CEASAR Intervention
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Stimulant Dependence, Methamphetamine-dependence
Pilot TMS for Methamphetamine Use Disorder
This is a pilot study to test the feasibility of a recruitment strategy and study protocol to examine the effects of a dual target transcranial magnetic stimulation treatment in methamphetamine use disorder.
- Conditions
- Stimulant Dependence, Methamphetamine-dependence, Addiction, Drug
- Trial name
- NCT04449055
- Testing
- Transcranial Magnetic Stimulation--DPFC first, MPFC second, Transcranial Magnetic Stimulation--MPFC first, DPFC second
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ryan M. Carnahan
Stimulant Use Disorder
PEX010-Assisted Therapy for Stimulant Use Disorder: A Safety, Feasibility and Efficacy Study
The goal of this clinical trial is to learn if PEX010 is effective for the treatment of Stimulant Use Disorder in adults. The study will also assess the safety and feasibility of administering PEX010 to this population.
- Trial name
- PATSUD (NCT06666010)
- Testing
- PEX010-Assisted Therapy, PEX010(01)
- Volunteers
- 86 people
- Sponsor
- Filament Health Corp.
HIV Infections, Pre-exposure Prophylaxis
PrEP Readiness Interventions for Supporting Motivation
The overarching goal of this formative research is to examine whether, and in what combination, contingency management (CM) and motivational interviewing (MI) can facilitate entry of stimulant-using men who have sex with men…
- Conditions
- HIV Infections, Pre-exposure Prophylaxis, Substance Use Disorders
- Trial name
- PRISM (NCT04205487)
- Testing
- Motivational Interviewing (MI), Contingency Management (CM)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida International University
Burnout, Secondary Trauma
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
The investigators propose to test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
- Conditions
- Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder
- Trial name
- NCT07886944
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Chestnut Health Systems
Prescription Drug Abuse (Not Dependent)
Examining Expectancy Challenges to Prevent Nonmedical Prescription Stimulant Use
Nonmedical prescription stimulant use (NPS) is commonly reported among college students for cognitive enhancement purposes, though it is associated with numerous negative psychological and physical consequences.
- Trial name
- NCT03648684
- Testing
- Caffeine-Based Expectancy Challenge
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Drug Abuse
Stimulant Abuser Groups to Engage in 12-Step
The purpose of this study is to determine whether a combined group and individual 12-Step facilitative (TSF) intervention, Stimulant Abuser Groups to Engage in 12 -Step (STAGE-12), improves substance -related outcomes.
- Trial name
- STAGE-12 (NCT00573183)
- Testing
- STAGE-12, Treatment as Usual
- Where
- 10 sites in United States
- Volunteers
- 471 people
- Sponsor
- University of Washington