Clinical trials: Stomach Diseases
Gastroparesis
Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis
Gastric Per-Oral Endoscopic Myotomy (G-POEM) is a procedure for the Treatment of Gastroparesis.
- Trial name
- G-POEM (NCT04434781)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastric Cancer
Study of Cetuximab to Treat Gastric Cancer
The purpose of this study is to evaluate the efficacy and safety of cetuximab combined with FOLFIRI in patients with advanced gastric cancer who failed first-line chemotherapy
- Trial name
- STAGE (NCT00699881)
- Testing
- cetuximab
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Fudan University
Gastric Cancer (GC)
A Study on the Efficacy of Sodium Propionate Combined With Anti-PD-1 Immunotherapy in Gastric Cancer
Eligible patients were randomized into two groups: the sodium propionate group and the control group. In the control group, patients received placebo combined with anti-PD-1 therapy plus chemotherapy without additional sodium…
- Trial name
- PAPGC (NCT07615907)
- Testing
- Sodium propionate
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jinling Hospital, China
Type 2 Diabetes Mellitus, Insulin Resistance
Bariatric Surgery And Adipose Inflammation Dysfunction and Type 2 Diabetes Mellitus
The focus of this proposal is to define the mechanism by which bariatric surgery acutely improves insulin sensitivity. Our central hypothesis is that drastically reduced caloric intake early after Bariatric surgery improves the…
- Trial name
- NCT01882036
- Testing
- Gastric Bypass w/ matched hypocaloric diet, Hypocaloric diet
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Minnesota
Type 2 Diabetes Mellitus
Medically Reproducing Bariatric Surgery
Type 2 diabetes (DM2) is a chronic disease affecting 29 million Americans and a leading cause of blindness, kidney failure, and limb loss (Engelgau et al 2004).
- Trial name
- MRB (NCT03225209)
- Testing
- OPTIFAST
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Moahad S Dar
Gastro-Intestinal Disorder
Ionizing Radiation During Endoscopic Procedures (ENDORAY Study)
The primary objective of this prospective study was to describe the evolution of dose reference levels (DRLs) in a specialized French center during endoscopic procedures involving ionizing radiation and performed without a…
- Trial name
- ENDORAY (NCT07009587)
- Testing
- Endoscopy
- Where
- France
- Volunteers
- 2,782 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Colon Cancer, Gastric Cancer
Integrated Care Pathway in Oncology (PASSION)
A centralized unit for integrated management of care pathway in Oncology has been created. This unit settles the patients' appointments (biopsy, intravenous device, chemotherapy, imaging, oncologist...).
- Conditions
- Colon Cancer, Gastric Cancer, Pancreatic Cancer, Thoracic Neoplasms
- Trial name
- PASSION (NCT04235556)
- Testing
- Care pathway unit
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Adenocarcinoma, Gastric Cancer
Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis
Background: Three-fourths of people diagnosed with gastric cancer will die from it. Researchers want to see if giving cancer drugs in a new way can help people live longer and delay the time it takes for the cancer to grow.
- Conditions
- Gastric Adenocarcinoma, Gastric Cancer, Esophagogastric Junction, Peritoneal Carcinomatosis
- Trial name
- NCT04034251
- Testing
- Paclitaxel, Capecitabine, BardPort Titanium Implanted Port with Peritoneal Catheter
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Stomach Neoplasms
The Safety and Feasibility of Laparoscopic-assisted Gastrectomy for Advanced Gastric Cancer After Neoadjuvant Chemotherapy
The purpose of this study is to explore the safety, feasibility, long-term and oncologicaloutcomes of laparoscopic-assisted gastrectomy for advanced Gastric Cancer after neoadjuvant chemotherapy.
- Trial name
- NCT02902575
- Testing
- Laparoscopic-assisted gastrectomy with D2 lymphadenectomy
- Volunteers
- 80 people
- Sponsor
- Fujian Medical University
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
MSI-H/dMMR Gastroesophageal-junction Cancer, MSI-H/dMMR Gastric Cancer
A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers.
This study will investigate the safety, tolerability, and antitumor activity of S095029 (anti-NKG2A antibody) in combination with pembrolizumab in in microsatellite instability-high/Defective mismatch repair (MSI-H/dMMR) locally…
- Trial name
- NCT06116136
- Testing
- S095029, pembrolizumab 200 mg (KEYTRUDA ®)
- Where
- 49 sites in United States, Australia and 13 more
- Volunteers
- 48 people
- Sponsor
- Servier Bio-Innovation LLC
Gastric Cancer
Hematological Dynamic Scores for Predicting Survival and Treatment Response for Advanced Gastric Cancer After Neoadjuvant Therapy
HMDLS, based on hematological markers, could effectively distinguish the long-term efficacy of AGC patients after NAT. The predictive performance of nomogram-HMDLS was better than ypTNM stage, achieving better prognostic…
- Trial name
- NCT06573307
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Chang-Ming Huang, Prof.
Gastric Diffuse Large B-cell Lymphoma
First-line Antibiotic Therapy for Early-stage HP(+) Gastric Pure DLBCL
Aims: A nationwide study to prospectively validate 1. The complete histological and molecular remission rate for antibiotics as 1st-line therapy for early-stage Hp-positive gastric pure (de novo) DLBCL 2.
- Trial name
- NCT02388581
- Testing
- Lansoprazole, Amoxicillin, Clarithromycin, Metronidazole
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Health Research Institutes, Taiwan
Gastric Adenocarcinoma
Characterisation of the Intratumoral Microbiome in Gastric Adenocarcinoma: to a Personalised Medicine
In this study, gastric tumours and adjacent healthy mucosa will be collected from gastric cancer patients operated on for curative purposes.
- Trial name
- MICROGAS (NCT05800236)
- Testing
- Gastrectomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Stage IV Gastric Cancer
S-1 Combined Cisplatin HIPEC for Palliative Operation Gastric Cancer of Stage IV Limited Peritoneal Metastasis
This study is designed to investigate the efficacy of S-1 plus cisplatin hyperthermic intraperitoneal chemotherapy for advanced gastric patients of gastric cytoreductive surgery (CRS)
- Trial name
- NCT02291211
- Testing
- S-1 plus cisplatin HIPEC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Colorectal Neoplasms Malignant, Surgical Procedures, Operative
Tracheal Colonization and Outcome After Major Abdominal Cancer Surgery
The goals of this study were to investigate whether two anesthesia regimens, with and without N2O, and bacterial colonization influence respiratory complications after major abdominal surgery for cancer.
- Conditions
- Colorectal Neoplasms Malignant, Surgical Procedures, Operative, Stomach Neoplasms, Pancreatic Cancer, Adult
- Trial name
- NCT04002128
- Testing
- Tracheal aspirates and nasal smears were taken in all the patients. Laparotomies were performed in all patients.
- Volunteers
- 120 people
- Sponsor
- Osijek University Hospital
Advanced Cancer, Advanced Malignancies
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
The primary purpose of this study is to assess the safety and tolerability of AB598 in participants with advanced malignancies.
- Conditions
- Advanced Cancer, Advanced Malignancies, Bladder Cancer, Cervical Cancer
- Trial name
- ARC-25 (NCT05891171)
- Testing
- AB598, Zimberelimab, Fluorouracil
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 40 people
- Sponsor
- Arcus Biosciences, Inc.
Functional Dyspepsia, Gastro Esophageal Reflux
Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
The purpose of this prospective cohort study is to compare upper GI symptoms and endoscopy findings in Canada with Japan and Iran, and correlate this with the upper GI microbiome.
- Conditions
- Functional Dyspepsia, Gastro Esophageal Reflux, Peptic Ulcer, Normal Control
- Trial name
- NCT03868267
- Where
- 3 sites in Canada, Iran and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hamilton Health Sciences Corporation
Stomach Cancer
Study of Perioperative Chemotherapy Combined With Tislelizumab and Trastuzumab in the Treatment of GC/EGC
Perioperative chemotherapy improves overall survival (OS) and disease-free survival (DFS) compared with surgery alone in patients with resectable gastric adenocarcinoma (GA) or gastro-oesophageal junction adenocarcinoma (GEJA).
- Trial name
- NCT04819971
- Testing
- Tirelizumab, Trastuzumab, Docetaxel
- Where
- China
- Volunteers
- 67 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Advanced Gastric Cancer, Advanced Colorectal Cancer
SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases
The goal of this clinical trial is to see if high- and low-dose radiotherapy combined with immunotherapy can work in patients with advanced gastric, colorectal, and ovarian cancers with peritoneal metastases, and to learn about…
- Conditions
- Advanced Gastric Cancer, Advanced Colorectal Cancer, Advanced Ovarian Cancer, Peritoneal Metastasis
- Trial name
- NCT06940921
- Testing
- Low-Dose Radiation(LDRT) + Stereotactic body radiotherapy (SBRT), Cadonilimab
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Zhang Tao
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