Clinical trials: Stomach Diseases
Bone Cancer, Brain Cancer
Enhanced Assistance During Radiotherapy for Unmet Essential Needs
This is a prospective single-arm study of an enhanced assistance intervention for patients with unmet essential needs undergoing >10 fractions of radiotherapy comparing delay-free completion of radiotherapy in study participants…
- Conditions
- Bone Cancer, Brain Cancer, Colorectal Cancer, Esophagus Cancer
- Trial name
- EARN (NCT06582849)
- Testing
- Standard assistance, Enhanced assistance
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Gastric Cancer
Human HER2-targeted Macrophages Therapy for HER2-positive Advanced Gastric Cancer With Peritoneal Metastases
The goal of this exploratory clinical trial is to evaluate the safety and efficacy of human anti-human epidermal growth factor receptor 2(HER2) Chimeric antigen receptor macrophage cells (CAR-M) in advanced HER2+ gastric cancer.
- Trial name
- NCT06224738
- Testing
- human HER2-targeted CAR-M cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- First People's Hospital of Hangzhou
Gastro-Intestinal Disorder
Can the SurgInfoBot Improve the Consent Process for Endoscopy? A Randomised Controlled Trial
Human-computer interactions or 'Chatbots' have been utilized in a variety of healthcare settings, including the promotion of positive healthcare behaviors, the deliverance of psychological therapy, and the performance of…
- Trial name
- NCT05159921
- Testing
- Access to an automated conversational agent (SurgInfoBot)
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tallaght University Hospital
Obstructive Sleep Apnea, Diabetes Mellitus
The Effect of Lifestyle Intervention Versus Gastric Bypass on Various Comorbidities in Morbidly Obese Subjects
This follow up study (>1 year) aims to compare the effects of lifestyle intervention and gastric by pass surgery on various comorbidities associated with morbid obesity.
- Conditions
- Obstructive Sleep Apnea, Diabetes Mellitus, Hypertension
- Trial name
- NCT00273104
- Testing
- Bariatric surgery, Intensive lifestyle intervention
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- The Hospital of Vestfold
Gastroesophageal Reflux
GI Reflux in Lung Transplant and Its Relationship to Chronic Rejection
Recent data has suggested that GER (gastric reflux) may worsen after lung transplantation and potentially increase the risk of chronic rejection (CR) after lung transplantation.
- Trial name
- LTXGERD (NCT00455078)
- Testing
- esophagogastroduodenoscopy, Standard GER questionnaire (RDQ), Scintigraphic evaluation of solid gastric emptying
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Gastric Ultrasonography, Gastric Volume
Gastric Ultrasound in Diabetic and Non-Diabetic Pregnant Women
Perioperative aspiration is particularly concerning in pregnant women due to anatomical changes. To mitigate this risk, pre-anesthetic fasting is recommended, with varying guidelines.
- Conditions
- Gastric Ultrasonography, Gastric Volume, Pulmonary Aspiration, Diabetic Pregnancy
- Trial name
- NCT05959135
- Testing
- Gastric ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Solid Tumor
Study of EOC317 in Chinese Patients With Advanced Solid Tumors
This is an open-label, single-arm phase 1, dose escalation study of EOC317 in patients with advanced solid tumors.
- Trial name
- NCT03583125
- Testing
- EOC317
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Taizhou EOC Pharma Co., Ltd.
Gastric Cancer Stage III
A Study to Evaluate Camrelizumab in Combination With Docetaxel +S-1 as Adjuvant Treatment Therapy in Stage III Gastric Cancer
To evaluate the efficacy and safety of Camrelizumab in Combination With Docetaxel +S-1 Sequenced by Camrelizumab+S-1 as Adjuvant Treatment Therapy in Stage III Gastric Cancer (PD-L1 + / MSI-H / EBV +/dMMR) .
- Trial name
- NCT04152889
- Testing
- Camrelizumab, S-1, Docetaxel
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
GERD
ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)
OBJECTIVES To study the safety and efficacy of Endoscopic Anti Reflux Mucosal Ablation (ARMA) procedure for the treatment of proton pump inhibitor (PPI) dependent gastro-esophageal reflux disease (GERD) DESIGN OF THE Prospective…
- Trial name
- ARMA (NCT04243668)
- Testing
- ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)
- Where
- India
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Solid Tumor, Advanced Cancer
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
This is an open label, multi-center, multiple dose Phase 1 study to evaluate the safety, tolerability, MTD PK, and PD of TJ033721 (givastomig) in subjects with advanced or metastatic solid tumors.
- Conditions
- Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer
- Trial name
- NCT04900818
- Testing
- TJ033721 (givastomig), TJ033721 (givastomig) , nivolumab, chemotherapy, TJ033721 (givastomig), chemotherapy
- Where
- 21 sites in United States, China
- Volunteers
- 330 people
- Sponsor
- I-Mab Biopharma US Limited
Atrophic Gastritis
Observation on the Efficacy of Radiofrequency Ablation for Patients With Moderate to Severe Gastric Atrophy With Enterosis With or Without Atrophy of Intraepithelial Neoplasia: An Observational Study
The aim of this observational study was to understand the effect of radiofrequency ablation on subjects with moderate to severe gastric atrophy with enterocolitis with or without low-grade intraepithelial neoplasia who underwent…
- Trial name
- NCT06751212
- Testing
- Radiofrequency ablation alone
- Volunteers
- 62 people
- Sponsor
- Xiuli Zuo
Cancer
Interleukin-12 in Treating Patients With Refractory Advanced-Stage Ovarian Cancer or Abdominal Cancer
Phase I trial to study the effectiveness of interleukin-12 in treating patients with refractory ovarian or abdominal cancers. Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a persons's…
- Trial name
- NCT00003439
- Testing
- recombinant interleukin-12
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux Disease, Heartburn
Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease
About 60% of patients with typical gastroesophageal reflux symptoms such as heartburn and regurgitation are considered to have non-erosive reflux disease (NERD).
- Trial name
- NCT01338077
- Testing
- Sodium alginate, Omeprazole
- Where
- Taiwan
- Volunteers
- 195 people
- Sponsor
- Chang Gung Memorial Hospital
Oesophageal Cancer, Gastric Cancer
Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types
The aim of the project is to demonstrate superior detection ratio of [18F]AlF-FAPI-74 PET/CT compared to [18F]FDG PET/CT or conventional imaging in treatment-naïve, newly diagnosed patients with oesophagogastric adenocarcinoma…
- Conditions
- Oesophageal Cancer, Gastric Cancer, Pancreatic Ductal Adenocarcinoma, FAP
- Trial name
- FAPIDO (NCT06782412)
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- 3 sites in Belgium
- Volunteers
- 109 people
- Sponsor
- KU Leuven
Morbid Obesity
Comparison of the Absorption of Hydrolyzed or Intact Proteins in Morbid Obese Patients After the Roux Y Gastric Bypass
The gastric bypass can reduce the bioavailability of food proteins. The bioavailability of hydrolyzed proteins may be higher than intact proteins.
- Trial name
- RyDIGEST (NCT04934826)
- Testing
- Hydrolyzed Proteins, Intact proteins
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastro Esophageal Reflux Disease
Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance (Encore)
Study Hypothesis: This study is designed as an integral part of the development of new or improved features or components of the Bravo® pH Monitoring System and may serve verification and validation purposes.
- Trial name
- NCT01788085
- Testing
- Bravo pH monitoring procedure
- Where
- Israel
- Sponsor
- Medtronic - MITG
Morbid Obesity
Laparoscopic Internal Gastric Banding, New Simple and Costless Weight Loss Procedure
The purpose of this study is to study the effectiveness of laparoscopic internal gastric banding as a treatment for morbid obesity in comparison to laparoscopic sleeve gastrectomy
- Trial name
- LIGB (NCT02878525)
- Testing
- Laparoscopic internal gastric banding, laparoscopic sleeve gastrectomy
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Gastric Retention
Impact of Neuropathy on the Risk of Semaglutide-Induced Gastric Retention
A prospective, single-center, observational study to compare the risk of gastric retention between the exposure group (with neuropathy) and non-exposure group (without neuropathy) in diabetic patients receiving uninterrupted…
- Trial name
- NCT07156591
- Testing
- Esophagogastroduodenoscopy
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Fudan University
Gastric Cancer
The Efficacy and Safety of Benmelstobart for GC/EGC
The goal of this clinical trial is to evaluate the major pathological response (MPR) rate of locally advanced gastric cancer / gastroesophageal junction cancer treated with bemosumab combined with antiangiogenic drugs and…
- Trial name
- EASOBFGE (NCT06603974)
- Testing
- surgery, Benmelstobart, tegafur
- Volunteers
- 48 people
- Sponsor
- Xijing Hospital
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