Clinical trials: Stomach Disorders
Gastric Cancer
Neoadjuvant Combination Chemotherapy of DCS and DCF in Patients With Locally Advanced Gastric Adenocarcinoma
Number of patients planned The study adopted two parallel phase II studies, with the same P1 and P0 in each arm, suggested by Logan.
- Trial name
- NCT01286766
- Testing
- DCS (docetaxel with cisplatin with TS-1), DCF (docetaxel with cisplatin with 5-FU)
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Yonsei University
Relapsed Malignant Solid Neoplasm
A Study Evaluating the Safety and Efficacy of AUR107 in Patients With Relapsed Advanced Malignancies (SHAKTI-1)
An open-label, first-in-human, Phase 1 study in adult patients with relapsed advanced malignancies will be done to assess AUR107 safety, tolerability, pharmacokinetics, pharmacodynamics, and optimal biological dose.
- Trial name
- NCT05865002
- Testing
- AUR107
- Where
- 37 sites in India
- Volunteers
- 50 people
- Sponsor
- Aurigene Discovery Technologies Limited
Cancer, Gastric
Gastric Cancer Risk Factors Associated With EU and CELAC Populations
The study uses a case-control design that examines the differences in types of exposures between cases defined with a pathological confirmation of GC diagnosis, and controls, defined as patients to whom a gastroscopy was…
- Trial name
- LEGACY-1 (NCT03957031)
- Where
- 8 sites in Argentina, Chile and 5 more
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Stage IV Cancer
Study on the Adverse Drug Reactions (ADRs) of Apatinib and Their Biomarker Correlations
The tolerability of apatinib, an effective antiangiogenic agent, varies greatly in patients with stage IV cancer during treatment.
- Trial name
- NCT03475589
- Testing
- apatinib
- Where
- China
- Volunteers
- 217 people
- Sponsor
- Sun Yat-sen University
Prediabetes, Normoglycemic
Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects
Aim of the study is to investigate the postprandial response on blood glucose, insulin, C-peptide, incretin response and gastric emptying after intake of collagen hydrolysate compared to placebo in normoglycemic and in…
- Trial name
- NCT06789263
- Testing
- Collagen hydrolyzed peptides
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Gastro-esophageal Reflux Disease (GERD)
HRIM vs Mucosal Impedance in GERD Participants
Does baseline impedance measured during the landmark phase of esophageal High resolution impedance manometry HRIM correlates with direct mucosal impedance measurement and discriminates GERD from non GERD patients?
- Trial name
- NCT02812407
- Testing
- Mucosal Impedance
- Where
- United States
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 1
Relationship Between Gastric Emptying and Glycemic Variability in Type 1 Diabetes Mellitus
With this study, the investigators hoped to learn if the rate at which food empties from the stomach affects blood sugar values.
- Trial name
- NCT02755064
- Testing
- Erythromycin lactobionate, [13C]-Spirulina, Erythromycin Ethylsuccinate Suspension
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Adil Bharucha
Gastro Intestinal Bleeding, Upper Gastrointestinal Bleeding
Metoclopramide, Azithromycin, or Nondrug Pretreatment for UGIB to Reduce Second Endoscopy
Early endoscopy is an integral part of the management plan for patients presenting with clinical signs of severe or ongoing UGIB.
- Trial name
- MANPURSE (NCT03840057)
- Testing
- Azithromycin Injection, Metoclopramide Injectable Solution, Sodium chloride 0.9%
- Where
- United States
- Volunteers
- 435 people
- Sponsor
- Waihong Chung
Gastric Cancer, Peritoneal Carcinomatosis
Cytoreductive Surgery and Intraperitoneal Chemotherapy for Stomach CAncer: a Feasibility Study
Rationale: For patients with peritoneal metastases of gastric origin, there is no consensus on the optimal treatment strategy. Several Asian and Western studies demonstrated hyperthermic intraperitoneal chemotherapy (HIPEC) and…
- Conditions
- Gastric Cancer, Peritoneal Carcinomatosis, HIPEC
- Trial name
- CISCA (NCT03150628)
- Testing
- Perioperative chemotherapy, Cytoreduction, HIPEC
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Richard van Hillegersberg
Advanced Solid Tumor, Metastatic Solid Tumor
A Study of KK2269 in Adult Participants With Solid Tumors
This is a first-in-human study of KK2269. Part 1 and Part 2 will be conducted as a multicenter, open-label, non-randomized, dose-escalation study.
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT06266299
- Testing
- KK2269, Docetaxel
- Where
- 32 sites in United States, Japan
- Volunteers
- 83 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Breast Cancer, Gastric Cancer
Phase I Study of Pyrotinib in Patients With HER2-positive Solid Tumors
Part 1: to assess the safety and tolerability of pyrotinib and to define the maximum tolerated dose (MTD) of pyrotinib in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive advanced solid tumors (metastatic…
- Conditions
- Breast Cancer, Gastric Cancer, Solid Tumors, NSCLC
- Trial name
- NCT02500199
- Testing
- Pyrotinib
- Where
- 10 sites in United States
- Volunteers
- 50 people
- Sponsor
- Hengrui Therapeutics, Inc.
Obesity
How Gas-Filled Intragastric Balloons or Endoscopic Sleeve Gastroplasty Affect Hunger, Hunger Hormones, and Gastric Emptying Compared to Meal Replacements
The disease obesity continues to be a major health issue in the US with over one third of the population having a mass index >30 kg/m2.
- Trial name
- NCT04306445
- Testing
- GF-IGB: Obalon Balloon, Medically Supervised Meal Replacement Program: My New Weigh, Endoscopic sleeve gastroplasty: (ESG)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Neuroendocrine Tumor Carcinoid, Neuroendocrine Tumor of Pancreas
68Ga-DOTATOC Radio-Guided Surgery With β-Probe in GEP-NET
In gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), radical surgery provides good long-term outcome and low recurrence rates.
- Conditions
- Neuroendocrine Tumor Carcinoid, Neuroendocrine Tumor of Pancreas, Gep Net
- Trial name
- RGS-GEP-NET (NCT05448157)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- European Institute of Oncology
Esophageal Cancer, Gastric Cancer
Combination Chemotherapy in Treating Patients With Unresectable Locally Advanced or Metastatic Stomach Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00006081
- Testing
- Bryostatin-1, Paclitaxel (Taxol)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer With Positive Peritoneal Exfoliative Cytology
Diagnosis of Peritoneal Exfoliative Cytology-positive Gastric Cancer Based on Artificial Intelligence-driven Virtual Biopsy Technology
This clinical study aims to develop and evaluate an artificial intelligence (AI)-driven virtual biopsy technology for the diagnosis of gastric cancer with positive peritoneal exfoliative cytology (PEC).
- Trial name
- GC-CY1 (NCT06759467)
- Testing
- AI-Driven Virtual Biopsy for Diagnosis of Peritoneal Exfoliative Cytology-Positive Gastric Cance
- Where
- China
- Volunteers
- 346 people
- Sponsor
- Qun Zhao
Obesity, Morbid
Comparison of Stapler Line Bleeding Control Techniquessurgery
Introduction RYGB surgeon; Have become increasingly morbid obesity treatment methods with improvements in minimally invasive surgery.
- Trial name
- NCT03240367
- Testing
- Coutery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ersin Gündoğan
Jaundice
Biliary Drainage in Patients With Duodenal Metal Stent
This is a retrospective study to evaluate the outcomes of endoscopic biliary drainage according to the timing of distal malignant biliary obstruction (MBO) in relation to gastric outlet obstruction (GOO) and the location of GOO.
- Trial name
- NCT02376907
- Testing
- Biliary drainage
- Where
- 25 sites in China, Hong Kong and 7 more
- Volunteers
- 200 people
- Sponsor
- Tokyo University
Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
This clinical trial is studying solid tumor cancers. A solid tumor is one that starts in part of your body like your lungs or liver instead of your blood.
- Conditions
- Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma, HER2 Low Breast Neoplasms, HER2 Positive Breast Neoplasms
- Trial name
- NCT06157892
- Testing
- disitamab vedotin, tucatinib
- Where
- 135 sites in United States, Australia and 8 more
- Volunteers
- 54 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Morbid Obesity
Efficacy of IV Acetaminophen in Acute Post-Operative Pain Control in Laparoscopic Roux-en-Y Gastric Bypass Surgery (LRYGBP) Patients
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is a common type of surgery in which length of stay and morbidity is intimately associated with post-operative nausea and vomiting (PONV) and recovery of bowel function.
- Trial name
- IV APAP (NCT01460667)
- Testing
- IV acetaminophen, IV normal saline
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- McLaren Regional Medical Center
Gastro-esophageal Reflux Disease, Functional Dyspepsia
Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia
Our group recently studied the relationship between intra-gastric pressure (IGP) and reflux events after a meal, both in gastro-esophageal reflux disease (GERD) and in healthy volunteers (HV).
- Conditions
- Gastro-esophageal Reflux Disease, Functional Dyspepsia, Health
- Trial name
- NCT03788109
- Testing
- device: combined solid state HRiM
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven