Clinical trials: Stomatognathic Disease
Caries, Dental Pulp Exposure
Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Background: Dental caries is considered an oral health problem worldwide. In Chile the last national epidemiological study (2007) showed a national prevalence of dental caries in children 6 years (70.3%) and 12 (62.5%).
- Trial name
- NCT02492841
- Testing
- Mineral trioxide aggregate, Calcium hydroxide, Biodentine
- Where
- Chile
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Tooth-loss
Impact of Tooth Loss and Denture on Oral Senses and Food Preferences
Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste…
- Trial name
- AlimaPAC (NCT04281056)
- Testing
- Tooth removal and their replacement by means of a denture
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peri-Implantitis
Prevention of Dental Implant Diseases
The aim of this study is to determine the effect of regular antibacterial photodynamic Lumoral® treatment on gingival health and plaque volume, and anti-inflammatory effect of daily double light therapy on implant teeth.
- Trial name
- NCT05871229
- Testing
- Lumoral Treatment, Standard treatment for peri-implantitis
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Hanna Lähteenmäki
Lip, Cleft, Lip Scar
Evaluation of a HA Dermal Filler in the Treatment of Lip Deformity
Early postnatal repair of cleft lip and palate aims at the development of the child through reconstruction of the face soon after birth.
- Trial name
- FENTHA (NCT05825170)
- Testing
- FASY L
- Where
- 3 sites in France
- Volunteers
- 20 people
- Sponsor
- Symatese
Necrotic Pulp, Apical Periodontitis
Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis
The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation…
- Trial name
- NCT04018456
- Testing
- Biodentine, White MTA
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Dentofacial Deformities
Splintless Virtual Surgical Plan with Mandible-first Technique: 3D Accuracy Analysis
Accuracy assessment through three-dimensional superposition of the post-operative volumetric CT and the digital therapeutic project files.
- Trial name
- MandiFirst (NCT06907745)
- Testing
- Bimaxillary Osteotomy
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Xerostomia, Dry Mouth
Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial
The goal of this clinical is to assess the efficacy of natural enzymes mouthwash in the treatment of xerostomia (dry mouth). The main questions it aims to answer are: (1) the efficacy of natural enzymes mouthwash in the…
- Trial name
- NCT05640362
- Testing
- Natural enzymes mouthwash, Benzydamine mouthwash
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Orthodontic Appliances, Removable, Dental Plaque
Cleaning Methods for Clear Aligners
The goal of this clinical trial is to learn which cleaning method best removes bacteria from clear plastic aligners. Clear aligners are removable orthodontic trays worn to straighten teeth.
- Conditions
- Orthodontic Appliances, Removable, Dental Plaque, Biofilms, Disinfection
- Trial name
- NCT07610603
- Testing
- Toothbrushing of clear aligner with water, Chlorhexidine gluconate 0.2% oral rinse, Effervescent aligner cleaning tablet
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Temporomandibular Joint Disorders
The Effect of Piroxicam Addition During Arthrocentesis on Mouth Opening and Postoperative Pain
TMDs is an ancient condition discovered thousands of years ago. Historians state that the ancient Egyptians were the first who managed TMDs. They manually treated joint dislocation by away similar to ours nowadays.
- Trial name
- NCT06508203
- Testing
- arthrocentesis with lactate ringer only, arthrocentesis with lactate ringer followed by injection with piroxicam 2 ml (40mg)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sjogren's Syndrome, Dry Eye
Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease
This project will examine the similarities and differences of the ocular surface and tear film in patients with Sjogren's syndrome related to dry eye, severe dry eye and those who do not have dry eye.
- Trial name
- JADE (NCT00809003)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Root Canal Infection, Periapical Abscess
Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral…
- Conditions
- Root Canal Infection, Periapical Abscess, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT05778227
- Testing
- Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Periodontitis
Accuracy of Artificial Intelligence-Assisted Staging and Grading for Diagnosis of Periodontitis.
This observational study aims to develop and assess the accuracy, specificity, and sensitivity of a deep learning model for the classification of periodontitis using panoramic radiographs and clinical data inputs.
- Trial name
- NCT07113327
- Testing
- Artificial Intelligence-Assisted Staging and Grading for Diagnosis of Periodontitis
- Where
- Egypt
- Volunteers
- 47 people
- Sponsor
- Ain Shams University
Class III Malocclusion, Hyoid Bone
The Effect of Orthopedic Face Mask Use on Head Posture and Pharyngeal Airway
The aim of this study was to evaluate the changes in head posture, position of the hyoid bone, pharyngeal airway and cervical posture after the use of Petit type face mask in patients with skeletal class III malocclusion (ANB…
- Trial name
- NCT05114642
- Testing
- Skeletal Class III Malocclusion Treatment with Face Mask Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Taner OZTURK, DDS, MS
Hypomineralization Molar Incisor
Laser Therapy and Flouride Therapy in Desensibilization Hypomineralized Teeth
To investigate the efficacy of laser therapy associated with fluorotherapy in the desensibitization of hypomineralized teeth in children 8 to 12 years of age. A randomized blinded clinical trial will be conducted.
- Trial name
- LTAFTIDHT (NCT03823170)
- Testing
- Laser therapy, Fluorotherapy, Laser therapy and Fluorotherapy
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universidade Ceuma
Periodontitis
The Efficacy of Scaling and Root Planing on Endothelin-1 Level
Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.
- Trial name
- clinical (NCT06784869)
- Testing
- Scaling and root surface debritment
- Volunteers
- 24 people
- Sponsor
- University of Baghdad
Gingival Recession
Effect of Low-Level Laser on Pain and Healing of Donor Site Following Free Gingival Graft
The aim of this randomized split-mouth design clinical trial is to clinically evaluate the effectiveness of diode laser in the healing of donor site of palate in free gingival graft.
- Trial name
- NCT02896283
- Testing
- Low-level laser therapy, Turned-off laser
- Where
- Iran
- Volunteers
- 12 people
- Sponsor
- Tehran University of Medical Sciences
Apical Periodontitis
E. Faecalis Prevalence in Primary and Secondary Endodontic Infections: a Pre-post Microbial Analysis Following Chemo-mechanical Preparation
Post-treatment apical periodontitis is a fairly prevalent condition frequently caused by a persistent endodontic infection due to failure of the endodontic treatment.
- Trial name
- NCT04637659
- Testing
- Root Canal Treatment
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Siena
Nasopharyngeal Carcinoma
Triprilimab(JS001) and Chemotherapy Combined With Local Treatment for Multiple Metastatic NPC
This study is a randomized, phase II, prospective, multicenter clinical trial to evaluate the efficacy and tolerability of JS001 and chemotherapy combined with local treatment in patients with multiple metastatic nasopharyngeal…
- Trial name
- NCT04421469
- Testing
- Triprilimab(JS001)
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Fujian Cancer Hospital
Temporomandibular Joint Disorder Bilateral
Efficacy of Botulinum Toxin in Temporomandibular Disorders
Temporomandibular disorders (TMDs) represent a multifactorial pathological group that gives rise to a varied and complex symptomatology that includes decreased jaw movement, muscle and joint pain, joint crepitation and limitation…
- Trial name
- TMD (NCT05651256)
- Testing
- Botulinum toxin type A injection
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Maxillofacial Bone Defects, Alveolar Bone Atrophy
Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery
The purpose of this study is to evaluate safety and efficacy of gene-activated matrix ("Nucleostim") for regeneration of bone tissue in maxillofacial area.
- Conditions
- Maxillofacial Bone Defects, Alveolar Bone Atrophy, Jaw Fractures, Maxillofacial Bone Deformities
- Trial name
- NCT02293031
- Testing
- Gene-activated matrix "Nucleostim"
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- NextGen Company Limited
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