Clinical trials: Stomatognathic Disease
Periodontitis, Type 2 Diabetes
Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment
Diabetes and periodontal disease are the most common chronic multifactorial and inflammatory diseases in humans, and there is a bidirectional relationship between type 2 diabetes and periodontitis.
- Trial name
- NCT05454059
- Testing
- Non-surgical periodontal treatment, ELISA Test, Periodontal Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Dental Caries
Oral Health Knowledge and Caries Experience in Adults
This cross-sectional study assessed the level of oral health knowledge and its relationship with caries experience, independently of age and sex, in adult patients attending a university dental clinic in Gran Canaria (Spain).
- Trial name
- NCT07881380
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Las Palmas de Gran Canaria
Hyposalivation
The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora
The test group consisted of eighteen subjects with hyposalivation used probiotic tablets (≥ 4/day) and gel (once a week) (streptococci, bicarbonate and carbamide) for 3 months and 9 used placebo tablets and gel.
- Trial name
- NCT02677480
- Testing
- Test group, probiotic tablets and gel
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Göteborg University
Irreversible Pulpitis (Toothache)
Laser Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible Pulpitis
This study compares two methods used during full pulpotomy, a treatment for teeth with deep tooth decay that has exposed the dental pulp.
- Trial name
- NCT07761962
- Testing
- Diode laser full pulpotomy, Sodium hypochlorite pulpotomy
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Recurrent Nasopharyngeal Carcinoma
Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent NPC
A Prospective, Single-arm, Multicenter Clinical Study of Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent Nasopharyngeal Carcinoma
- Trial name
- NCT05350891
- Testing
- endoscopic surgery
- Where
- 8 sites in China
- Volunteers
- 77 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Alveolar Ridge Atrophy, Tooth Loss
Alveolar Ridge Splitting With Simvastatin/PRF Composite and Simultaneous Implant Placement
This randomized controlled clinical trial evaluated the effectiveness of platelet-rich fibrin (PRF) and a simvastatin/PRF composite combined with a xenogeneic bone graft during alveolar ridge splitting with simultaneous implant…
- Trial name
- ARS-SIMV (NCT07692620)
- Testing
- Alveolar Ridge Splitting with Simultaneous Implant Placement, Xenogeneic Bone Graft, Platelet-Rich Fibrin (PRF)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Maruwan Ali Alteer
Sjogren's Syndrome
Analyse of Inflammatory Activity of Sjögren's Syndrome on 68Ga-FAPI PET-CT
Sjögren's syndrome (SS) is a chronic autoimmune disease primarily affecting the salivary and lacrimal glands, leading to symptoms of dryness. Assessing the inflammatory activity is crucial for guiding treatment.
- Trial name
- NCT07062523
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Stevens-Johnson Syndrome
Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye
The purpose of this study is to evaluate the efficacy of 0.05% cyclosporin ophthalmic emulsion (Restasis) in patients with Stevens-Johnson syndrome that have dry eyes by subjective symptoms and signs.
- Trial name
- NCT01488396
- Testing
- 0.05%cyclosporin eye drop
- Where
- Thailand
- Volunteers
- 31 people
- Sponsor
- Mahidol University
Suspected Early Lyme Neuroborreliosis
Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis
The investigators will compare doxycycline and ceftriaxone in treatment of patients with suspected early Lyme neuroborreliosis and normal CSF cell count.
- Trial name
- NCT00942006
- Testing
- doxycycline, ceftriaxone
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Alveolar Bone Loss, Dental Implant
Evaluation of the Effect of Periimplant Soft Tissue Phenotype on Marginal Bone Loss
The goal of this clinical trial to test the effect of periimplant soft tissue phenotype in the participants with implant placed and at least 1 year after implant loading. The main questions it aims to answer are: 1.
- Conditions
- Alveolar Bone Loss, Dental Implant, Periimplantitis
- Trial name
- NCT05640284
- Testing
- Nuclear Factor-Kappa B Ligand (RANKL) analysis, Osteoprotegerin (OPG) analysis, Tumor Necrosis Factor Alpha (TNF-α) analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Necmettin Erbakan University
Sjogren's Syndrome, Autoimmune Diseases
Examining the Immunological Process of Autoimmune Patients
Sjögren's syndrome (SjS) is an autoimmune disease characterized primarily by exocrine gland dysfunction, specifically of the salivary and lacrimal glands, resulting in dry mouth and dry eyes symptoms.
- Conditions
- Sjogren's Syndrome, Autoimmune Diseases, Dry Eyes, Dry Mouth
- Trial name
- NCT02123147
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Ankyloglossia, Breastfeeding Support
Post-Procedural Manual Manipulation for Infant Ankyloglossia
The goal of this randomized control trial is to determine the impact of post-frenotomy manual manipulation on revision rates and breastfeeding outcomes.
- Trial name
- NCT06830148
- Testing
- Post-frenotomy manual manipulation
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Georgetown University
Oral Cavity Cancer
Study to Assess Biomarkers in Patients With Resectable Oral Cavity Cancer Randomized to Receive Preoperative Treatment
The objective of this study is to assess the biological effects in the primary tumor following a short, pre-operative course of treatment with PF-00298804 in patients with Oral Cavity Cancer.
- Trial name
- NCT01116843
- Testing
- PF-00299804
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
XEROSTOMIA
OGT Spray in the Management of Xerostomia in the Elderly
The primary objective of the trial is to evaluate the efficacy, safety and clinical acceptability of OGT oromucosal spray in the relief of symptoms and signs of xerostomia in comparison with a saliva substitute (European Medical…
- Trial name
- NCT00350350
- Testing
- oxygenated oil, medical device. Spray containing essentially oxygenated oil
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Laboratoires CARILENE
Endodontically Treated Teeth
Postoperative Pain After İntracanal Procedures
Aim: The aim of this study is to investigate the effects of different irrigation activation systems on pain after endodontic treatment in molar teeth with irreversible pulpitis.Post-operative pain values of the participants will…
- Trial name
- NCT04892355
- Testing
- Root canal irrigation
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Dental Plaque
Effect on Bacterial Glycolytic Acid Formation on Plaque
To determine the effect of an amino acid on bacterial glycolytic acid formation in human interdental plaque.
- Trial name
- NCT00762450
- Testing
- Triclosan, Fluoride, fluoride, Fluoride, triclosan, amino acid
- Where
- Switzerland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Nerve Injury, Orofacial Pain
Post-traumatic Neuropathy of the Trigeminal Nerve
This is retrospective research mainly aims to determine the patterns of symptoms, clinical and radiological findings and outcomes in patients with trigeminal neuropathy following trauma or iatrogenic damage and how this…
- Conditions
- Nerve Injury, Orofacial Pain, Trigeminal Nerve Injuries, Trigeminal Neuropathy
- Trial name
- NCT04612855
- Testing
- Groupwise comparison of primary and secondary outcomes
- Where
- Belgium
- Volunteers
- 1,333 people
- Sponsor
- KU Leuven
Caries, Dental
Clinical Evaluation of ELS Versus ELS Extra Resin Composite
Adhesive restorative materials are routinely used in operative dentistry to improve tooth tissues with minimal preparation, achieve more esthetic and long term restorations.
- Trial name
- NCT03306576
- Testing
- ELS Extra composite, ELS composite
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medipol University Hospital
Diabetes Mellitus Type 2 With Periodontal Disease
Using AR Dental Care Training System in HE on Periodontal Status, Blood Sugar Control and QoL in Patients With T2DM
The aim of this study was to evaluate the long-term effectiveness of an AR dental care training in health education on periodontal status, blood sugar control and quality of life in patients with poorly controlled type 2…
- Trial name
- NCT05941468
- Testing
- AR Dental Care Training System
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Recession, Gingival
Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative
24 patients will be treated with a coronally positioned tunnel with AlloDerm RTM with or without the addition of Enamel Matrix Derivative to compare the baseline and 6-month changes in recession defect coverage, clinical…
- Trial name
- NCT05565079
- Testing
- Regenerative tissue matrix and enamel matrix derivative, Regenerative tissue matrix
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Louisville
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