Clinical trials: Stomatognathic Disease
Dental Pain, Patient Satisfaction
The Impact of Minimally Invasive Restorative Techniques on Dental Pain in Pregnant Women
The aim of the present study was to compare the effectiveness of chemo-mechanical caries removal using Papacarie-Duo and Atraumatic Restorative Treatment (ART) in reducing dental pain in pregnant women.
- Trial name
- NCT04573608
- Testing
- Papacarie, Atraumatic Restorative Treatment
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Nourhan M.Aly
Cleft Palate, Cleft Lip
Targeting Surgeons' Decision-Making for Cleft Lip Surgery
Using separate prospective cohorts of patients who have lip revision and lip repair surgery, the objective of this clinical trial is to both qualitatively and quantitatively assess how surgeons integrate the objective measures…
- Trial name
- NCT03537976
- Testing
- Static Images and Facial Videos
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Tufts University
Oral Lichen Planus
Low Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus
The Injectable PRF (i-PRF) is a variant of PRF, which is a liquid blood derivative rich in leukocytes and acts as a growth factor release, with its potential anti-inflammatory role, it may alleviate the symptoms of OLP.
- Trial name
- NCT07846891
- Testing
- Injectable Platelet Rich Fibrin, Low Level Laser Therapy, Triamcinolone acetonide (injection)
- Where
- 2 sites in Egypt
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Oral Disease
COMPARISON OF THE EFFICIENCY OF MANUAL SINGLE HEADED AND TRIPLE HEADED TOOTHBRUSHES IN REMOVING DENTAL PLAQUE AND USER EXPERIENCE
Background: Poor oral hygiene can be the result of negligence or because people cannot take care of their own oral hygiene due to limited dexterity. Dental plaque results in dental decay and periodontal disease over time.
- Trial name
- NCT07433374
- Testing
- triple headed manual toothbrush, manual single headed toothbrush
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Cleft Palate
Suprazygomatic Block in Cleft Palate Surgery in Children
Cleft palate (CP) is a common congenital malformation, with an incidence ranging from 0.1 to 1.1 per 1000 births depending on the population group (liau et al, 2010).
- Trial name
- NCT03412474
- Testing
- Bupivacaine, Dexmedetomidine, paracetamol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer
ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx
This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck…
- Conditions
- Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer, Throat Cancer, Tonsil Cancer
- Trial name
- NCT06915038
- Testing
- NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Mucositis
Local Anesthetic Treatment of Oral Pain in Patients With Mucositis
Oral mucositis is a damage to the mucosa of the oral cavity and pharynx. It is a serious and painful adverse effect caused by the radio therapy and/or chemo therapy patients with head and neck cancer receive.
- Trial name
- NCT02252926
- Testing
- Bupivacaine, Standard treatment (lidocaine viscous solution, morphine, paracetamol, NSAID, gabapentin)
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Hvidovre University Hospital
Abrasion, Discoloration, Tooth
Enamel Abrasion and Stain Removal Efficacy
Enamel abrasion and stain removal efficacy of two whitening toothpastes
- Trial name
- NCT05619315
- Testing
- Charcoal -based whitening toothpaste, Calcium carbonate /perlite containing whitening toothpaste.
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CAD
Untreated periodontal infection may result in transient bacteremia and toxaemia which may be the cause of adverse systemic events, leading to various systemic disorders.
- Trial name
- NCT05828368
- Testing
- Non surgical periodontal therapy
- Where
- 2 sites in India
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Weight Gain, Sialorrhea
FazaClo Outcomes in the Control of Schizophrenia (FOCUS) Study Survey
AZUR Pharma has received several reports from practicing psychiatrists prescribing FazaClo showing that FazaClo patients start losing body weight instead of keep gaining it, after being switched from other clozapine products or…
- Trial name
- FOCUS (NCT00683891)
- Testing
- FazaClo (clozapine, USP) ODT
- Where
- 2 sites in United States
- Sponsor
- Azur Pharma, Inc
Tongue; Anomaly
Prevalence of Tongue Anomalies in Egyptian Children
The purpose of the study is to determine the prevalence of tongue anomalies in a group of Egyptian children and to relate the presence of malocclusion in cases of macroglossia, tongue tie and microglossia.
- Trial name
- NCT05779618
- Testing
- no intervention
- Where
- 2 sites in Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Chronic Apical Periodontitis of Pulpal Origin
The Effect of Using Reciprocal Files Alone and With Different Files on Postoperative Pain
This study aims to investigate the effects of using the Wave One Gold file alone and in combination with different files on postoperative pain in patients with asymptomatic apical periodontitis.
- Trial name
- NCT06833515
- Testing
- one flare+wave one gold glider+wave one gold, wave one gold glider+wave one gold, wave one gold
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Harran University
Recession, Gingival
Clinical Evaluation of Laterally Closed Tunnel Technique Versus Coronally Advanced Flap Combined With Connective Tissue Graft for the Treatment of Isolated RT2 Gingival Recession
The aim of this study is to evaluate reduction of recession depth using lateral closed tunnel technique versus CAF technique using connective tissue graft in single RT2 gingival recession cases.
- Trial name
- NCT05823415
- Testing
- Laterally Closed Tunnel with CTG, CAF with CTG
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Alveolar Bone Loss, Alveolar Ridge Abnormality
Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation
The current st udy's objective was to validate the repeated effect of i PRF with autogenous bone on the of gingival thickness , width a n d volumetric bone changes durig maxillary alveolar augmentation using cone beam computer…
- Trial name
- I-PRF (NCT06711250)
- Testing
- khoury technique, khoury technique with i-PRF injections
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypopharyngeal Cancer
Neoadjuvant Chemotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)
The investigators will examine whether 2-cycles of DFP chemotherapy before definitive concurrent chemoradiation therapy (CCRT) can improve progression-free survival in locally advanced (Stage III \& IVM0) hypopharyngeal and base…
- Trial name
- NCT01312350
- Testing
- neoadjuvant docetaxel/cisplatin/fluorouracil, No treatment before definitive CCRT
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Dental White Spots
Enamel Damages Following De-bracketing From Infiltrated Surfaces
Demineralisation and white-spot caries often occures during MB treatment. While resin infiltration has been proved to stop progression of enamel demineralisation, there is still a paucity of information in the literature…
- Trial name
- NCT02359318
- Testing
- Resin infiltration, Bonding and debonding of brackets.
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Peri-Implantitis
Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis
A total of 100 adult volunteers of both sexes will be enrolled in the project. The study will be conducted within an international consortium formed for the project, comprising the following institutions: Wroclaw Medical…
- Trial name
- PERI-EDU (NCT07012915)
- Testing
- Blood testing
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Acute Coronary Syndrome, Periodontitis
Neutrophil Elastase, Elastase Alpha-1 Proteinase, Periodontitis, Gingival Crevicular Fluid and Acute Coronary Syndrome
Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS).
- Trial name
- NCT04785235
- Testing
- Non-Surgical Periodontal Therapy
- Volunteers
- 43 people
- Sponsor
- Baskent University
Nasopharyngeal Cancer
Nab-paclitaxel Based TPX Neoadjuvant Chemotherapy for NPC Patients: a Dose-escalation Study
Neoadjuvant chemotherapy followed by concurrent chemoradiation (CCRT) has been recommended in the treatment of locoregionally-advanced nasopharyngeal carcinoma (NPC), with docetaxel, cisplatin (DDP) and 5-fluorouracil (5-Fu)…
- Trial name
- NCT04850235
- Testing
- Nab paclitaxel
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-sen University
Periodontitis Stage III
Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis
The goal of this clinical trial is to learn if a treatment called injectable platelet-rich fibrin (i-PRF) helps improve gum health in people with a type of gum disease called Stage 3 Grade B periodontitis.
- Trial name
- NCT07029035
- Testing
- İnjectable platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
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