Clinical trials: Stomatognathic Disease
Toothache
Percocet vs. Bupivicaine for Toothaches in the ED
The goal of this study is to compare the speed and adequacy of pain relief in Emergency Department patients with a toothache after an oral analgesic or a local anesthetic administered as a nerve block or by local infiltration.
- Trial name
- NCT02862691
- Testing
- Acetaminophen/Oxycodone (Oral analgesic), Bupivicaine (Injectable local anesthetic)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Stony Brook University
Levonorgestrel Adverse Reaction, Temporomandibular Joint Disorders
Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System
The goal of this clinical trial is to investigate the possible role of levonorgestrel intrauterine system use(LIU) in the pathogenesis of temporomandibular joint disorder (TMD).
- Conditions
- Levonorgestrel Adverse Reaction, Temporomandibular Joint Disorders, Temporomandibular Disorder
- Trial name
- NCT06500390
- Testing
- Examination of temporomandibular joint and masticator muscles
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Dental Plaque, Oral Biofilm
Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns
This in-vivo study investigates early (48h), mature (2 weeks) and long-term (3 months) biofilm formation and composition on temporary push-on cones (exchangeable conical rings) made of noble-alloy-based materials (Pagalinor, PA)…
- Conditions
- Dental Plaque, Oral Biofilm, Peri-implantitis
- Trial name
- NCT05122897
- Testing
- Rings made of PA (test), Rings made of TAN (control)
- Where
- Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial
This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars.
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Dental Pain, Inferior Alveolar Nerve Block Failure, Local Anesthesia
- Trial name
- NCT07130760
- Testing
- Intraligamentary Injection, Inferior Alveolar Nerve Block
- Where
- 2 sites in Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Aula Dental Avanzada
Tongue Cancer
Normative Ranges of Lingual Strength and Endurance and the Impact of the IOPI Lingual Strength Trainer on Quantitative Functional Outcomes and Patient-Reported Outcomes After Partial Glossectomy or Hemiglossectomy for Oral Tongue Cancer, An Unblinded: Randomized Pilot Study
The purpose of this study is to learn more about tongue strength and endurance by using the Iowa Oral Performance Instrument (IOPI). The IOPI is a device that measures tongue pressure.
- Trial name
- NCT07124520
- Testing
- Iowa Oral Performance Instrument (IOPI)
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Retention/Attrition of Midwives
Midwifery Retention Project
The NHS is experiencing a significant workforce crisis across the service; with currently >130, 000 vacancies, therefore, national efforts to improve recruitment and retention are a priority.
- Trial name
- NCT05686824
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- King's College London
Trigeminal Neuralgia
The Clinical Benefits of the Combination Use of Acupuncture and Antihistamine on Trigeminal Neuralgia
Trigeminal neuralgia is a paroxysmal extreme pain and is an unmet clinical need, we hope that our discovery about the antihistamine and acupuncture can be used in the treatment trigeminal neuralgia.
- Trial name
- NCT04384224
- Testing
- acupuncture
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Jaw Deformity, Facial Asymmetry
Computational Modeling for Prediction of Acoustic Changes in Vowel Production Due to Orthognathic Surgery
A computational model of human sound production based on high quality anatomic measurements and physical laws of sound propagation cannot be accomplished without a comprehensive data set including both 3D-images of the speaker's…
- Trial name
- PUMA (NCT01887977)
- Testing
- MRI examination
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Periodontal Diseases
Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 6-months follow-up, the…
- Trial name
- NCT05720481
- Testing
- Full mouth Scaling and root planing, Quadrant Scaling and root planing
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Catania
Temporomandibular Joint Disorders
The Relationship of Orthodontic Malocclusions With Temporomandibular Joint Disorders
The patients who applied to the hospital for orthodontic treatment were asked various questions to evaluate their oral health related quality of life, malocclusions and self reported temporomandibular joint problems.
- Trial name
- NCT04123236
- Testing
- Age 0-18, Age 18-26, Girls
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- University of Gaziantep
PreDiabetes, Diabetes Mellitus, Type 2
Oral Endocannabinoids in People With Prediabetes and Diabetes
This study evaluates the relationship of endocannabinoids in saliva with inflammation and oral dysbacteriosis present in people with periodontal disease and prediabetes/type 2 diabetes
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Obesity, Oral Dysbiosis
- Trial name
- SMILE (NCT06040164)
- Testing
- Observational study
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Periapical Disease
Effect of Piezoelectric Surgery on Quality of Life and Periradicular Healing After Endodontic Surgery
This study will compare the effect of piezo Vs bur on quality of life and healing after endodontic surgery.
- Trial name
- NCT04358887
- Testing
- piezoelectric surgery, conventional bur
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Bruxism
Trabecular Bone Changes After Periodontal Treatment in Patients With and Without Bruxism
This prospective observational cohort study evaluated changes in the trabecular bone structure around teeth after nonsurgical periodontal treatment in patients with periodontitis, with and without bruxism.
- Trial name
- NCT07904455
- Testing
- Bruxism Status
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Mustafa Kemal University
Molar Hypomineralization, Incisor
Resin Infiltration vs Ionomer-Based Fluoride Varnish for the Prevention of Post-Eruptive Breakdown in Molars With Mild MIH
round/Objective: The objective of this clinical trial is to evaluate the clinical efficacy of a resin infiltrant (Icon®, DMG) compared to an ionomer-based fluoride varnish (Clinpro XT®, 3M) in preventing post-eruptive enamel…
- Trial name
- MIH (NCT07443878)
- Testing
- Resin Infiltrant (Icon®, DMG), Varnish-Modified Glass Ionomer (Clinpro XT®, 3M)
- Where
- Mexico
- Volunteers
- 17 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Type II Diabetes, Periodontal Disease
Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes
The purpose of this research intervention is to assess the oral health status and periodontal health of patients with diabetes hospitalized on a general medicine service, and to assess the effect of providing dental prophylaxis…
- Trial name
- NCT02914743
- Testing
- Motivational Interviewing, Dental cleaning
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Endodontically Treated Teeth, Post Operative Pain
The Effect of Instrumentation and Obturation on Postoperative Pain in Retreatment
Objectives: The aim of this study was to assess postoperative pain in prospective randomized clinical trial comparing Reciproc or hand instrument and also different obturation techniques in one visit of endodontic retreatment.
- Trial name
- NCT04789343
- Testing
- Root canal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Marmara University
Plaque, Dental
Analysis of the Effectiveness of the Use of Glycine Powder and Angled Implant Brush in Oral Hygiene Maintenance in Patients Reinstated With Columbus Bridge ProtocolTM
This study aims at comparing different procedures of Professional Oral Hygiene (POH) and Domiciliary Oral Hygiene (DOH) in Columbus Bridge ProtocolTM full-arch reinstated patients by dividing a sample of at least 74 patients into…
- Trial name
- NCT05965076
- Testing
- Glycine Perio Flow, Angled Toothbrush, Standard Professional Oral Hygiene
- Where
- Italy
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- A.O.U. Città della Salute e della Scienza
Trigeminal Neuralgia, Pain, Neuropathic
FMRI Assessment After Radiofrequency in Trigeminal Neuralgia
To investigate the brain activations related to TN, using fMRI, and to evaluate changes in these activations following the application of pulsed and thermal Radiofrequency lesioning to the gasserien ganglion.
- Trial name
- NCT03305289
- Testing
- pulsed Radiofrequency, thermal Radiofrequency
- Volunteers
- 20 people
- Sponsor
- Assiut University
Chronic Periodontitis
STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.
Human periodontitis is a group of highly prevalent oral inflammatory diseases and infections with relatively easy treatment and preventive features.
- Trial name
- NCT01906450
- Testing
- Scaling and root planing plus Azithromycin
- Where
- Colombia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Head and Neck Cancer, Oral Mucositis
Ph 2 Open Label Study of GC4419 to Reduce SOM Associated With Chemoradiotherapy for Head and Neck Cancer
GTI-4419-202 is a Phase 2 open-label study of the effects of GC4419 (IV) when administered in combination with IMRT and cisplatin to up to subjects with head and neck cancer, who are at high risk for Severe Oral Mucositis (SOM)
- Trial name
- NCT04529850
- Testing
- Drug: GC4419, Intensity-modulated radiation therapy (IMRT), Cisplatin
- Where
- 24 sites in Belgium, Czechia and 4 more
- Volunteers
- 38 people
- Sponsor
- Galera Therapeutics, Inc.
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