Clinical trials: Stomatognathic Diseases
Nasopharyngeal Cancinoma (NPC)
Concurrent Chemoradiotherapy With or Without Metronomic Capecitabine in High-Risk T1-2N1M0 NPC
This Phase III multicenter trial investigates treatment intensification for high-risk, stage T1-2N1M0 nasopharyngeal carcinoma. Patients with high-risk features (>3 metastatic lymph nodes, necrosis, or confluence) receive…
- Trial name
- NCT07248670
- Testing
- metronomic adjuvant chemotherapy with capecitabine
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Chongqing University Cancer Hospital
Mouth Neoplasms, Oral Cancers
Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative
The goal of this clinical trial is to compare the survival outcomes, morbidity and cost-effectiveness of sentinel node biopsy versus limited elective neck dissection in node-negative early oral cancers.
- Conditions
- Mouth Neoplasms, Oral Cancers, Oral Squamous Cell Carcinoma (OSCC), Oral Squamous Cell Carcinomas
- Trial name
- SECOND N0 (NCT05774483)
- Testing
- Sentinel Node Biopsy, Limited Elective Neck Dissection
- Where
- 3 sites in India
- Volunteers
- 508 people
- Sponsor
- Tata Memorial Hospital
Dental Caries
The Effectiveness of iTero Element 5D NIRI System in Early Proximal Caries Detection in Permanent Teeth
As a new emerging technology for the diagnosis of dental caries, near-infrared imaging requires further research and validation to determine its effectiveness.
- Trial name
- NCT06276959
- Testing
- intraoral scanning, clinical oral examination, cone-beam computed tomography
- Where
- China
- Volunteers
- 120 people
- Sponsor
- West China College of Stomatology
Squamous Cell Carcinoma of the Head and Neck
A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer
This was a Phase 2a trial to investigate the safety and biological activity of the RIX-2 Regimen in patients with untreated, resectable squamous cell cancer of the head and neck (HNSCC).
- Trial name
- NCT00210470
- Testing
- IRX-2, Cyclophosphamide, Indomethacin
- Volunteers
- 27 people
- Sponsor
- Brooklyn ImmunoTherapeutics, LLC
Bruxism
Which is More Effective in Management of Bruxism: Botox or Occlusal Splints
The aim of this study is to compare the efficacy of Botulinum toxin (Botox) and traditional occlusal splints for the management of bruxism in edentulous patients rehabilitated with MIOD
- Trial name
- NCT04366869
- Testing
- overdenture, occlusal splint, Botox
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Oropharyngeal Cancer, Squamous Cell Carcinoma of the Oropharynx
A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)
Single center, non-randomized Phase II study enrolling Stage I-II p16+ oropharyngeal cancer patients to one of two de-escalation treatment paradigms: (1) receive surgery followed by observation or risk-adjusted adjuvant radiation…
- Trial name
- NCT05894083
- Testing
- Surgery, Chemoradiation, Observation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Michigan Rogel Cancer Center
Periodontal Diseases
Evaluation of Saliva IL-6 Levels and Periodontitis
The aim of this study was to analyze the association between salivary IL-6 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced salivary IL-6 levels
- Trial name
- NCT04382105
- Testing
- Observation of salivary IL-6 levels
- Where
- Italy
- Volunteers
- 287 people
- Sponsor
- University of Messina
Xerostomia
Effect of Low-level Laser Therapy on Salivary Flow, pH and Quality of Life in Irradiated Oropharyngeal Cancer Patients
There are multiple treatment modalities for head and neck cancer. They include radiation therapy, chemotherapy and surgery. Radiation therapy aims to control the tumor with minimum damage to adjacent tissues.
- Trial name
- NCT04738227
- Testing
- Low-Level Laser Therapy
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Ziauddin University
Mandibular Deficiency
Mandibular Reconstruction With Axially Vascularised Bone Substitutes
Mandibular reconstruction is necessary following trauma, tumour resections and extensive infections resulting in severe defects of the mandibular arch.
- Trial name
- NCT04001842
- Testing
- Surgical reconstruction of the mandible using an axially vascularized bone construct
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- University of Alexandria
Dental Caries
Primary Molars Restorations With Encapsulated or Hand-Mixed Glass Ionomer: Clinical Trial
The aim of this RCT is to evaluate the survival of different glass ionomer cement in minimally invasive restorations, with different handling characteristics: hand-mixed versus encapsulated.
- Trial name
- NCT02274142
- Testing
- Restoration with hand-mixed material, Restoration with Encapsulated material, Encapsulated glass ionomer cement (EQUIA - GC Corp).
- Where
- Brazil
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis
Adjuvant Treatment in Elderly Patients With Periodontitis Through the Administration of a Supplement Rich in Oleuropein From the Olive Leaf
Life expectancy has dramatically increased in the last century, although this process has not been always accompanied by an equivalent increase in healthy life expectancy.
- Trial name
- OLIVAGING (NCT05482373)
- Testing
- Oleuropein from olive tree
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Jose Luis Quiles Morales
Dental Implant Failed, Peri-Implantitis
20-year Implant Survival in Periodontally Healthy and Compromised Patients
The aim of this study will be to compare the long-term outcomes of sandblasted and acid-etched (SLA) implants in patients previously treated for periodontitis and in periodontally healthy patients (PHP) after a follow-up of at…
- Conditions
- Dental Implant Failed, Peri-Implantitis, Bone Loss
- Trial name
- NCT04983758
- Testing
- Oral Rehabilitation with dental implants
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chemotherapy Induced Oral Mucositis
Effect of Oral Ice Chips to Prevent Chemotherapy-Induced Oral Mucositis in Patient With Solid Tumor Treated With 5 Fluorouracil and Methotrexate
The goal of this randomized controlled clinical trial is to determine whether oral cryotherapy using ice chips can prevent and reduce the incidence and severity of chemotherapy-induced oral mucositis in adult cancer patients…
- Trial name
- NCT07327476
- Testing
- Oral Cryotherapy (Ice Chips), Standard Oral Care (Mouthwash)
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- University of Health Sciences Lahore
Dental Caries
Retention and Caries Prevention of Giomer Sealant With or Without Diode Laser Pre-treatment: A Randomized Controlled Trial
This randomized controlled trial evaluates the effect of diode laser pre-treatment on the retention and caries prevention of giomer-based fissure sealants in young adults aged 17-22 years.
- Trial name
- NCT07612540
- Testing
- phosphoric acid pretreatment
- Where
- 3 sites in Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Recession, Mucogingival Surgery, Gingival Recession
Combined Bilaminar Tunnel Technique in Treating Difficult Gingival Recessions
The goal of this clinical trial is to learn if the combined bilaminar tunnel technique works to treat anatomically difficult gingival recessions.
- Conditions
- Gingival Recession, Mucogingival Surgery, Gingival Recession, Root Coverage
- Trial name
- NCT07616960
- Testing
- mucogingival surgery
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Choying Lin
Gingival Recession
PRF for Treating Maxillary Gingival Recession
This is a split-mouth, randomized, controlled clinical trial that aims to evaluate the clinical efficacy of platelet-rich fibrin (PRF) membranes in conjunction with coronally advanced flap (CAF) in treating maxillary gingival…
- Trial name
- NCT05267015
- Testing
- Gingival coverage using coronally advanced flap and a connective tissue graft, Gingival coverage using coronally advanced flap and platelet rich fibrin membranes
- Where
- Palestinian Territories
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Nasopharyngeal Neoplasms
A New EBV Related Technologies of T Cells in Treating Malignant Tumors and Clinical Application
The purpose of this study is to evaluate the safety of the designed LMP1-CAR -T cells and determine whether the CAR-T cells are effective in the treatment of EBV associated malignant tumors.
- Trial name
- NCT02980315
- Testing
- CAR-T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Pierre Robin Sequence, Brainstem Dysfunction
Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence
Introduction Pierre Robin Sequence, PRS, incidence is about one hundred births per year in France. The main neonatal clinical manifestations are secondary to airway obstruction and food difficulties related to swallowing…
- Trial name
- DYSROBIN (NCT03423017)
- Testing
- Recording of data
- Where
- 2 sites in France
- Volunteers
- 113 people
- Sponsor
- Hospices Civils de Lyon
Streptococcal Infections, Pharyngitis
Treatment of Group A Beta Hemolytic Streptococcal Pharyngitis in Children in Low Resource Settings
The purpose of this study was to compare the microbiological effects of two different treatments: a single dose of intramuscular benzathine penicillin G (IM BPG) vs.
- Trial name
- TOPS (NCT01156740)
- Testing
- Penicillin G, Benzathine, Amoxicillin
- Where
- 3 sites in Brazil, Croatia and 1 more
- Volunteers
- 558 people
- Sponsor
- Johns Hopkins University
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