Clinical trials: Stomatognathic Diseases
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Inflammatory Myopathies, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06821659
- Testing
- anti-CD19 CAR-T cells
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Gingival Recession
Periosteal Pedicle Flap Versus Subepithelial Connective Tissue Graft in Management of Gingival Recession
Gingival recession is defined as the apical shift of the marginal gingiva from its normal position on the crown of the tooth to levels on the root surface beyond the cemento-enamel junction (CEJ).Various surgical procedures…
- Trial name
- NCT06529640
- Testing
- SCTG followed by coronally postionting flap, periosteal flap followed by coronally postionting flap
- Volunteers
- 10 people
- Sponsor
- Assiut University
Oropharyngeal Neoplasms, Robotic Surgery and/or Radiotherapy
Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
To test a new radiation treatment design based on where your cancer is located. Most participants with oropharyngeal cancer are treated with radiation to both sides of the neck.
- Conditions
- Oropharyngeal Neoplasms, Robotic Surgery and/or Radiotherapy, Lymphoscintigraphy
- Trial name
- NCT06167291
- Testing
- Arm 1- Ipsilateral
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Bell's Palsy, Facial Paralysis
Combined Effects of Proprioceptive Neuromuscular Facilitation (PNF) and Neural Mobilization on Improving Facial Symmetry in Patients With Bells Palsy
Bell's palsy is an acute,unilateral facial paresis that significantly affects patient's facial symmetry,motor function and quality of life.The primary goal of this randomized controlled trial is to determine if integrating the…
- Conditions
- Bell's Palsy, Facial Paralysis, Facial Asymmetry
- Trial name
- NCT07758543
- Testing
- GROUP A COMBINED THERAPY GROUP, GROUP B PNF GROUP
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Foundation University Islamabad
Class II Div 1 Malocclusion
Root Resorption in Class II Div 1 Malocclusion in Upper 1st Premolar Extraction vs Distalization
Rationale: Class II Division 1 malocclusion is characterized by upper anterior teeth protrusion resulting in upper lip protrusion and convex facial profile, which are considered esthetically unfavorable.
- Trial name
- NCT05639725
- Testing
- maxillary Ist premolar extraction, SURGICAL
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Alveolar Osteitis
Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis
Alveolar osteitis (AO; syn. dry socket) is one of the most frequent complications following tooth removal and it is defined as presence of severe postoperative pain in and around the extraction site, which increases in severity…
- Trial name
- NCT04853589
- Testing
- Hyaluronic acid gel, Hyaluronic acid gel + carrier
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Sjogren's Syndrome
B-dependant Rare AutoImmune diseaSES - Cohort of Patients With Suspected Diagnosis of Primitive Sjögren Syndrome
The objectif is to study the diagnosis performance of the different classification criteria in reference to the gold standard consisting of the diagnosis made by expert doctors after standardized assessment, of pSS (primary…
- Trial name
- BRAISES-DiaPSS (NCT04931160)
- Testing
- Blood, fluid, sells and urine samples
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Alveolar Bone Loss
Biologically Oriented Alveolar Ridge Preservation (BARP) With and Without Advanced Platelet-Rich Fibrin Plus (A-PRF+)
Twenty patients were selected from the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking for extraction of non-restorable maxillary premolar teeth prior to…
- Trial name
- NCT07869082
- Testing
- Socket preservation by deproteinized bovine bone graft, socket preservation by deproteinized bovine bone graft mixed with advanced PRF+
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Sjogren's Disease
Evaluation of Ocular Surface Inflammatory Mediators Effected by Lotemax
The purpose of this study is to evaluate the effects of an anti-inflammatory drug (Lotemax®) on the surface of the eye and tear film (a film that coats the eye which is made up of oil and water).
- Trial name
- NCT02322528
- Testing
- Administration of Lotemax
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Bladder Cancer, Breast Cancer
Chemotherapy in Treating Patients With Refractory Advanced Solid Tumors or Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of…
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT00004065
- Testing
- tanespimycin
- Where
- 2 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Histopathology, Periodontitis
Effects of Smoking on Oral Tissue Samples
Smoking negatively affects the prognosis of periodontal disease by impairing tissue healing. While micronucleus is the most popular parameter for demonstrating DNA damage, inflammatory cell and vascular densities are the most…
- Conditions
- Histopathology, Periodontitis, Smoking, Micronuclei
- Trial name
- NCT05484765
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul Medipol University Hospital
Nasopharyngeal Neoplasms
Study Using Intensity-modulated Radiation Therapy in Patients With Nasopharynx Cancer to Permit Sparing of Contralateral Parotid Gland Function
One of the side effects of standard radiation therapy for cancer of the nasopharynx is a permanent lessening of normal mouth moisture (saliva).
- Trial name
- NCT00123864
- Testing
- Intensity-modulated radiation therapy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Alberta Health services
Periodontal Diseases, Diabetes Mellitus
Anti Oxidant Enzymes and Total Antioxidant Levels in Diabetes Mellitus Type II Patients and Healthy Individuals With Periodontitis
To evaluate the role of antioxidants - superoxide dismutase, catalase, glutathione and total anti oxidant levels in the serum of chronic periodontitis patients and chronic periodontitis with DM Type II patients, then to compare…
- Conditions
- Periodontal Diseases, Diabetes Mellitus, Enzyme Disorder
- Trial name
- NCT04180332
- Testing
- Blood sample
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ajman University
Nasopharyngeal Carcinoma (NPC)
Development and Validation of a Biopsy Decision Model for Nasopharyngeal Carcinoma Based on Serological Markers and Endoscopic Features
An observational study combines retrospective and prospective cohorts to develop, validate, and compare models based on Epstein-Barr virus (EBV)-related blood biomarkers alone, nasopharyngeal endoscopic scores alone, and their…
- Trial name
- NCT07918755
- Testing
- Assessment of EBV-related blood biomarkers and nasopharyngeal endoscopic scores
- Where
- 2 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Healthy
Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria in Saliva and Bioaerosol Contamination
To evaluate the anti-bacterial, pre-procedural, clinical efficacy of Peroxyl mouthwash (1.5% hydrogen peroxide) in saliva and the reduction of bioaerosol contamination as compared to a matching placebo mouthwash (0.0% hydrogen…
- Trial name
- NCT04626778
- Testing
- Peroxyl Mouthwash
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentine Hypersensitivity
Psychophysical Characterization and Brain Correlates of Dentine Hypersensitivity
Up to date, devices capable of delivering controlled, calibrated, non-contact cold air stimuli in a MR environment are unavailable for quantitative sensory testing.
- Trial name
- NCT02929043
- Testing
- air puffs
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Orthodontic Appliance Complication, Tooth Demineralization
Fluoride Delivery to Prevent White Spots During Orthodontic Treatment
The aim of this 2-armed, parallel, randomised, controlled trial is to assess the effect of different ways of applying fluoride to teeth on the formation of white spots (enamel demineralisation), during orthodontic treatment with…
- Trial name
- FL4OWS (NCT05005689)
- Testing
- Fluoride mouthwash (0.05%; 225ppm)., Tooth Mousse Plus
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Temporomandibular Disorder
Effectiveness of a Manual Therapy Protocol in Patients With Masticatory Muscle Disorders
Comparing the efficiency between manual therapy protocol and effleurage in patients with temporomandibular disorders.
- Trial name
- NCT03556150
- Testing
- Manual Therapy protocol, Effleurage
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Mucositis Oral
Photobiomodulation Protocols in the Analgesia of Chemotherapy-induced Oral Mucositis in Children
Chemotherapy-induced oropharyngeal mucositis (OM) negatively impacts the quality of life of adult and pediatric patients by causing pain, dysphagia, dysgeusia and dysphonia.
- Trial name
- CURALASE01 (NCT04596410)
- Testing
- LLLT applied every other day, LLLT applied daily
- Where
- 16 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
Periodontal Diseases
In-office and Domiciliary Use of a New Ozonized Gel for the Management of Periodontal Disease
The aim of this study is to evaluate the efficacy of non-surgical periodontal therapy with supportive home oral care for the treatment of periodontal disease.
- Trial name
- NCT05254288
- Testing
- Chlorhexidine, Ozoral gels
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
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