Clinical trials: Stomatognathic System
Epidermal Necrolysis, Lyell Syndrome
LYell SYndrome MEsenchymal Stromal Cells Treatment
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions (SCARs) to drugs.
- Conditions
- Epidermal Necrolysis, Lyell Syndrome, Toxic Epidermal Necrolysis, Overlap Syndrome
- Trial name
- LYSYME (NCT04711200)
- Testing
- Adipose derived stromal cells intravenously injected
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mucositis, Dry Mouth
Effect of Fluoride Varnish and CPP-ACP on Oral and Salivary Symptoms During Chemotherapy
The purpose of this study was to investigate the effect of Fluoride varnish and Casein Phospho-Peptide Amorphous Calcium Phosphate (CPP-ACP) containing paste on oral symptoms and salivary characteristics in patients under…
- Conditions
- Mucositis, Dry Mouth, Infection
- Trial name
- NCT01737307
- Testing
- Fluoride varnish, Oral Hygiene, CPP-ACP
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Azad University of Medical Sciences
Pierre Robin Syndrome
Impact of Phonatory and Facial Morphology Disorders, on the Quality of Life of Adolescents With Pierre Robin Sequence
The study team has made the hypothesis that the intensity of the phonatory disorders (rhinolalia), and of the maxillo-mandibular growth anomalies (facial morphology), may have negative effects on the quality of life of…
- Trial name
- ADOROBIN (NCT03194178)
- Testing
- Pierre Robin sequence patients
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Imagine Institute
Colorectal Cancer, Head and Neck Cancer
NGR-TNF in Treating Patients With Advanced Solid Tumors
RATIONALE: Targeted therapy with tumor necrosis factor combined with a fusion protein may stop the growth of solid tumors by stopping blood flow to the tumor.
- Conditions
- Colorectal Cancer, Head and Neck Cancer, Kidney Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00098943
- Testing
- CNGRC peptide-TNF alpha conjugate
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 70 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cleft Lip
Osteogenesis and Dental Eruption Through Electrical Stimuli
The closure of the alveolar cleft as part of cleft lip and palate deformities is a procedure that, to this date, still demands great efforts from plastic surgeons.
- Trial name
- NCT00975208
- Volunteers
- 9 people
- Sponsor
- University of Guadalajara
Dental Fluorosis
Presence of Enamel Fluorosis in Libyan Children
Fluorosis is caused by hypomineralization in the enamel due to increased fluoride ingestion during early childhood (Cawson.1, Wong et al. 2, and Sudhir 3).
- Trial name
- NCT03746990
- Volunteers
- 1,935 people, healthy volunteers welcome
- Sponsor
- Ajman University
Breast Cancer, Colorectal Cancer
Positron Emission Tomography/Computed Tomography Scanning Before Surgery in Patients With Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, or Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography/computed tomography (PET/CT) scanning before surgery, may help measure the extent of disease.
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT01254591
- Testing
- 18F-fluoromisonidazole, fluorescence angiography, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College London (UCL) Cancer Institute
Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome
Thalidomide to Treat Oral Lesions in HIV-Infected Patients
This study will test the effectiveness of topical thalidomide in healing mouth sores in HIV infected patients. Oral (PO) thalidomide heals these sores at a dose of 200 mg per day.
- Conditions
- Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome, HIV Infection
- Trial name
- NCT00001524
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Bell Palsy
Intratympanic Stereoidal Injections for Facial Nerve Palsy
Bell's palsy is defined as a facial nerve palsy without any other known cause. The common practice for this disease consists of the use of oral steroids.
- Trial name
- NCT03371589
- Testing
- Dexamethasone
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
Periodontal Diseases, Gastritis
Evaluation of Microbial Status in Gastritis Patients in Different Periodontal Conditions
The aim of this study to evaluate the microbial profile in gastritis and healthy patients in different periodontal conditions via next generation technologies.
- Trial name
- NCT07378540
- Testing
- saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Sialorrhea, Amyotrophic Lateral Sclerosis
Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea
Evaluation of the decrease of the secretion of saliva in patients with amyotrophic lateral sclerosis by a local ultrasound-guided bilateral injection of botulinum toxin type A in parotids and submandibular glands.
- Trial name
- ALS-TOX (NCT01551940)
- Testing
- Botox injection
- Where
- 13 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Sialorrhea, Spastic Cerebral Palsy (sCP)
Effect of SCS Technique on Oromotor Skills in Children With CP
This study evaluates the clinical efficacy of the Strain Counter-Strain (SCS) technique on improving oromotor functions in children with spastic cerebral palsy.
- Conditions
- Sialorrhea, Spastic Cerebral Palsy (sCP), Strain Counterstrain Technique, Oral Motor Functions
- Trial name
- NCT07516860
- Testing
- Strain Counter-Strain (SCS), Designed Oral Motor Program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Healthy, Idiopathic Inflammatory Myopathies
A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases
The purpose of this study is to determine the safety and tolerability of XmAb657 in healthy participants and participants with autoimmune diseases.
- Conditions
- Healthy, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, Sjögren's Disease
- Trial name
- NCT07284797
- Testing
- XmAb657
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children
This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of…
- Trial name
- MIH (NCT07352813)
- Testing
- Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Oral Mucositis (Ulcerative) Due to Radiation
Dexpanthenol Mouthwash to Treat Oral Mucositis
Oral mucositis can be a significant problem for cancer patients. It is typically associated with pain and increased risk of infection and can lead to impaired nutritional status and inadequate hydration.it can be seen in the…
- Trial name
- NCT01318889
- Testing
- Dexpanthenol
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Palatal Expansion Technique, Malocclusion
Comparison Between Two Rates of Activation of Miniscrew-Supported Upper Jaw Expander in Adolescents
Miniscrew-supported maxillary expanders provide advantages over conventional tooth-supported expanders. However, there is no consensus in the literature regarding their activation protocol.
- Conditions
- Palatal Expansion Technique, Malocclusion, Posterior Crossbite, Maxillary Hypoplasia
- Trial name
- NCT04225637
- Testing
- Miniscrew-Supported Maxillary Expander- Slow activation, Miniscrew-Supported Maxillary Expander- Rapid activation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Mucositis, Gingivitis
Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis and Gingivitis
The purpose of this study is to analyze the efficacy of 0.12% chlorhexidine gluconate as a chemical adjuvant for the treatment of peri-implant mucositis in single implants compared with homologous teeth with gingivitis, in a…
- Trial name
- NCT02639377
- Testing
- Chlorhexidine gluconate
- Volunteers
- 29 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Sjogren's Syndrome (SS)
An Efficacy and Safety Study of Injectable Ravagalimab to Assess Change in EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) in Adult Participants With Moderately to Severely Active Primary Sjogren's Syndrome (pSS)
Sjogren's syndrome (SS) is a chronic, multisystem autoimmune disease characterized by lacrimal and salivary gland inflammation, with resultant dryness of the eyes and mouth and occasional glandular enlargement.
- Trial name
- NCT05217472
- Testing
- Ravaglimab, Ravagalimab
- Where
- Netherlands
- Sponsor
- AbbVie
Craniofacial Microsomia, Hemifacial Microsomia
Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)
This study is a multi-center, longitudinal cohort study of 125 infants with craniofacial microsomia (CFM) and 100 infants without craniofacial anomalies.
- Conditions
- Craniofacial Microsomia, Hemifacial Microsomia, Oculo-Auriculo-Vertebral-Syndrome, Goldenhar Syndrome
- Trial name
- CLOCK (NCT02224677)
- Where
- 5 sites in United States
- Volunteers
- 417 people
- Sponsor
- Seattle Children's Hospital
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