Clinical trials: Stones, Kidney
Ureteral Calculus, Ureterolithiasis
Silodosin Versus Tamsulosin for Treatment of Ureteral Stones
Ureteral calculi, commonly known as kidney stones, are a frequent cause of Emergency Department (ED) visits. These stones can get caught in the ureter (the tube connecting the kidney to the bladder) and cause symptoms including…
- Conditions
- Ureteral Calculus, Ureterolithiasis, Ureteral Stone
- Trial name
- NCT02369744
- Testing
- Silodosin, Tamsulosin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Albert Einstein Healthcare Network
Kidney Calculi
Stone Access and Removal (STAR) Study
The purpose of the study is to assess procedural completion, the post-operative stone clearance and the safety profile following robotic mini-Percutaneous Nephrolithotomy (PCNL) performed with the MONARCH Platform, Urology.
- Trial name
- STAR (NCT06330701)
- Testing
- Robotic-assisted mini-PCNL
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.
Cystinuria
Lipoic Acid Supplement for Cystine Stone
This study evaluates how daily alpha lipoic acid supplementation affects cystine kidney stone recurrence. Half of the subjects will receive 1200 mg alpha lipoic acid orally daily for three years, while the other half will receive…
- Trial name
- ALA (NCT02910531)
- Testing
- Alpha lipoic acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Chi, MD
Calcium Oxalate Urolithiasis
Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
The purpose of this research study is to assess the efficacy of ingesting a small amount of the harmless bacterium Oxalobacter formigenes in establishing residence in the guts of healthy participants and to determine whether this…
- Trial name
- NCT03752684
- Testing
- Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, Moderately high oxalate/low calcium diet colonized
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Ureterolithiases
Tamsulosin for Urolithiasis in the Emergency Dept
Urolithiasis is a disease that effects 12% of the population and its incidence is growing. In the US there are over 1.1 million visits annually to Emergency Departments for renal colic.
- Trial name
- STONE (NCT00382265)
- Testing
- tamsulosin
- Where
- 4 sites in United States
- Volunteers
- 512 people
- Sponsor
- Andrew Meltzer
Kidney Stones
AR Projections for Eye-gaze Evaluation in Phantoms
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07161024
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Nephrolithiasis, Urolithiasis
Vitamin D Repletion in Stone Formers With Hypercalciuria
Vitamin D plays a critical role in maintaining bone health, as well as preventing cardiovascular disease, cancer, and various autoimmune diseases, such as diabetes.
- Conditions
- Nephrolithiasis, Urolithiasis, Idiopathic Hypercalciuria, Vitamin D Deficiency
- Trial name
- NCT01295879
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York Presbyterian Hospital
Kidney Stone, Renal Stone
Antibiotic Selection Using Next Generation Sequencing vs Urine Culture
This is a randomized controlled clinical study evaluating the use of next-generation sequencing (NGS) to improve antibiotic prescribing before ureteroscopy or percutaneous nephrolithotomy.
- Conditions
- Kidney Stone, Renal Stone, Infection, Bacterial
- Trial name
- ACCESS (NCT04404855)
- Testing
- NGS + Antibiotic Recommendation, Standard of Care treatment
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Stone Ureter, Stone;Renal
Clinical Trial Evaluating the Efficiency of Holmium Laser Settings on Urinary Stones
The primary objective of this study is to compare the time to acceptable stone fragmentation during clinical use of the holmium laser when using energy settings 0.2J vs 0.8J.
- Conditions
- Stone Ureter, Stone;Renal, Surgery
- Trial name
- NCT03526458
- Testing
- Holmium:YAG laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Ureteral Calculi
The Predictive Value of Ureteral Jet Assessment With Ultrasound in Patients Presenting With Acute Renal Colic
This is a single institution, prospective study to evaluate the prognostic significance of renal and bladder ultrasound with ureteral jet assessment and its utility to evaluate the spontaneous stone passage rate of ureteral…
- Trial name
- NCT02577146
- Testing
- renal and bladder ultrasound with ureteral jet assessment
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Washington University School of Medicine
Recurrent Calcium Oxalate Kidney Stone Disease, Elevated Urinary Oxalate Levels
A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels
The primary purpose of this study is to evaluate the effect of lumasiran on the percent change in urinary oxalate excretion in patients with recurrent calcium oxalate kidney stone disease.
- Trial name
- NCT05161936
- Testing
- Lumasiran
- Where
- 31 sites in United States, Belgium and 4 more
- Volunteers
- 2 people
- Sponsor
- Alnylam Pharmaceuticals
Urolithiasis, Urinary Lithiasis
Impact of Renal Anatomy on Shock Wave Lithotripsy Outcomes for Lower Pole Kidney Stones
Kidney stone disease affects almost 10% of overall population, often requiring a surgical intervention. Currently, shock wave lithotripsy is considered a first-line treatment option for patients suffering from symptomatic kidney…
- Conditions
- Urolithiasis, Urinary Lithiasis, Kidney Calculi
- Trial name
- NCT01589484
- Testing
- SWL - Compact Delta Dornier Med Tech
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- University of Sao Paulo
Urolithiasis
Study of Tomography of Nephrolithiasis Evaluation
This is a multi-center, randomized controlled trial of ultrasonography (ultrasound) compared to computed tomography (CT) for the initial emergency room evaluation of patients with suspected renal colic.
- Trial name
- STONE (NCT01451931)
- Testing
- Point-of-care Ultrasound, Radiology Ultrasound, Radiology CT
- Where
- 15 sites in United States
- Volunteers
- 2,776 people
- Sponsor
- University of California, San Francisco
Kidney Stones, Nephrolithiasis
Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and…
- Trial name
- NCT05365477
- Testing
- Empiric Therapy: Diet, Empiric Therapy: Drug, Selective Therapy: Diet
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Vanderbilt University Medical Center
Hyperoxaluria
A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk.
This pilot study is proposing a novel approach to directly target intestinal oxalate absorption with the drug Tenapanor, which was recently FDA-approved for treating hyperphosphatemia in patients with chronic kidney disease.
- Trial name
- NCT06481150
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Secondary Hyperoxaluria, Nephrolithiasis
A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria
Identify individuals with greater absorption of oxalate based on increase in urinary oxalate excretion in response to a controlled oxalate-rich test meal.
- Conditions
- Secondary Hyperoxaluria, Nephrolithiasis, Hyperoxaluria, Kidney Stones
- Trial name
- NCT03095885
- Testing
- Test Meal
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Allena Pharmaceuticals
Healthy, Kidney Stone
Assessment of Endogenous Oxalate Synthesis
This study aims to determine the daily rate of endogenous synthesis of oxalate using carbon 13 oxalate isotope tracer technique and a low-oxalate controlled diet.
- Conditions
- Healthy, Kidney Stone, Obesity
- Trial name
- NCT05229952
- Testing
- Low-oxalate controlled diet, Primed, continuous intravenous infusion of 13C2-oxalate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Children, Obstructive Uropathy
Ureteral Stents Versus Percutaneous Nephrostomy for Initial Urinary Drainage
To compare percutaneous nephrostomy (PCN) versus double J stent (JJ) as an initial urinary drainage in children
- Conditions
- Children, Obstructive Uropathy, Acute Renal Failure, Ureteric Stones
- Trial name
- NCT02055430
- Testing
- percutaneous nephrostomy insertion, bilateral double J ureteric stent, Definitive stone management
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Urinary Stones
Prevention of Urinary Stones With Hydration
A randomized clinical trial to investigate the impact of increased fluid intake and increased urine output on the recurrence rate of urinary stone disease (USD) in adults and children.
- Trial name
- PUSH (NCT03244189)
- Testing
- Fluid prescription, Financial incentive, Structured Problem Solving
- Where
- 8 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Duke University
Overactive Bladder, Renal Colic
Preoperative Use of Darifenacin (Enablex) to Alleviate Postoperative Ureteral Stent Pain
This will be a randomized two arm prospective study to evaluate postoperative ureteral stent pain. One arm will be given 3 days of preoperative darifenacin and the control group will have the standard of care which is no…
- Conditions
- Overactive Bladder, Renal Colic, Pain, Postoperative
- Trial name
- NCT01189071
- Testing
- Darifenacin
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia