Clinical trials: Strain
Plasmodium Falciparum Infection
Malaria Challenge With NF54 Strain
The purpose of this study is to determine how many infected mosquito bites are required to reliably give volunteers a case of malaria. It is expected that volunteers will develop malaria and may have symptoms.
- Trial name
- NCT00744133
- Testing
- NF54 P. falciparum isolate
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
Safety and Immunogenicity of Two Doses of a Tetravalent Influenza Vaccine in Adults Aged 18 Years and Above
Evaluate the immune response and reactogenicity of H5N1 vaccination in adults aged 18 years and above (as part of a tetravalent vaccine)
- Trial name
- NCT00620815
- Testing
- Pandemic influenza vaccine + seasonal influenza vaccine /pandemic influenza vaccine, Pandemic influenza vaccine + seasonal influenza vaccine / pandemic influenza vaccine
- Where
- 2 sites in Germany
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Cytomegalovirus Infections
Evaluation of the Safety and Immune Responses of the Towne Strain of CMV in Seronegative Women
The purpose of this study is to evaluate the safety and effectiveness of a vaccine given to women ages 18-45 to prevent cytomegalovirus (CMV), which they may catch from their children who attend daycare centers.
- Trial name
- NCT00201448
- Testing
- Hepatitis A Vaccine, Towne CMV Vaccine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hyperthermia, Kidney Injury, Acute
Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain
Prolonged, high intensity work in a hot environment results in significant strain on the body, known as heat strain. Heat strain in hot occupational settings such as agriculture, fire suppression, and military work can lead to…
- Trial name
- NCT05710978
- Testing
- Work Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Myocardial Dysfunction
Effects of L-arginine on Myocardial Energetic Efficiency and Global Longitudinal Strain
The study is designed to evaluate the effects of L-arginine on myocardial structure and function and circulating microRNAs in patients with arterial hypertension.
- Trial name
- BIOCARDIO (NCT04626375)
- Testing
- Bioarginine
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federico II University
Heat Exposure, Healthy
Safe Indoor Temperature Limit for Fans
Extreme heat events are a significant global threat to health and wellbeing, and result in more morbidity and mortality than all other natural disasters combined.
- Conditions
- Heat Exposure, Healthy, Young Adults, Fans
- Trial name
- NCT06584903
- Testing
- Temperature Ramp Protocol
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Heart Failure, Atrial Fibrillation
Statins in Reducing Events in the Elderly (STAREE) Heart Sub-study
The STAREE-HEART sub-study will examine the effect of statin treatment over a 3-year period compared with placebo on markers of cardiac ageing (myocardial dysfunction).
- Conditions
- Heart Failure, Atrial Fibrillation, Healthy Ageing, Hypercholesterolemia
- Trial name
- STAREE-HEART (NCT04536870)
- Testing
- Echocardiography, ECG screening
- Where
- 2 sites in Australia
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Monash University
Muscle Strain, Neuromuscular Diseases
Posterior Chain EMG Patterns in Athletes With and Without Hamstring Injury
This cross-sectional observational study investigated posterior chain muscle activation patterns in football players with and without a history of hamstring strain injury.
- Conditions
- Muscle Strain, Neuromuscular Diseases, Athletic Injuries
- Trial name
- NCT07171385
- Testing
- Nordic Hamstring Curl (NHC), Kettlebell Swing (KS), Supine Sliding Single-Leg Curl (SSLC)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Poliomyelitis
Consistency Study for Three Commercial Lots of Inactivated Poliomyelitis Vaccine Made From Sabin Strain
A randomized and blind clinical consistency study for three commercial batches of Inactivated Poliomyelitis Vaccine Made From Sabin Strain (sIPV) for immunogenicity and safety evaluation.
- Trial name
- NCT04224519
- Testing
- sIPV batch 1, sIPV batch 2, sIPV batch 3
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
SARS-CoV-2 Infection
Dose, Safety and Pathogenicity of SARS-CoV-2 (COVID-19) Omicron Virus (BA.5)
An Exploratory Study to Establish the Dose, Safety and Pathogenicity of a SARS-CoV-2 Omicron Challenge Strain (BA.5) in Healthy Participants 18 to 40 Years of Age
- Trial name
- NCT06492564
- Testing
- SARS-CoV-2 omicron virus dose arm 1, SARS-CoV-2 omicron virus dose arm 2, SARS-CoV-2 omicron virus dose arm 3
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvivo
Anterior Pelvic Tilt, Sprint Kinematics
"Ecological Program Changes Pelvic Kinematics in Soccer Players: Pilot Study on Hamstring Injury Implications"
The present pilot study aimed to investigate whether a 6-week multicomponent intervention, comprising a structural lumbopelvic and sprint technique program, could reduce anterior pelvic tilt in soccer players who regularly…
- Trial name
- NCT06551532
- Testing
- Multicomponent program
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- RX2 Sports and Health
Escherichia Infection
Efficacy Study of IM Administered CssBA+dmLT Against Moderate-severe Diarrhea in Human Infection Model With ETEC Strain B7A in Healthy Adults
The study is designed to evaluate the safety, immunogenicity, and efficacy of the intramuscular administration of a CS6 based vaccine (CssBA) against ETEC co-administered with double mutant labile toxin (dmLT) in preventing…
- Trial name
- NCT06692907
- Testing
- B7A (ETEC challenge strain), CssBA, dmLT
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gastrointestinal Symptoms
Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
The purpose of this study was to investigate the dose response effect of Bifidobacterium lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms.
- Trial name
- NCT01171014
- Testing
- Bifidobacterium lactis HN019
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Influenza Immunization
Study to Evaluate Safety and Immunogenicity of a Pandemic Flu H5 mRNA Vaccine in Healthy Adults Aged 18 Years and Older
The purpose of this study is to evaluate a pandemic flu H5 strain messenger ribonucleic acid (mRNA) vaccine at 3 dose levels (low, medium, and high) in comparison with placebo in 276 healthy adult participants to select the…
- Trial name
- NCT06727058
- Testing
- Pandemic flu H5 mRNA vaccine
- Where
- 14 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Eye Strain, Eye Strain of Both Eyes
Study of Non-inferiority Between Manzanilla Sophia® and Meticel Ofteno® 0.5% for Providing a Soothing Sensation to the Eyes.
This is a phase IV clinical study to demonstrate the non-inferiority of Manzanilla Sophia® compared to Meticel Ofteno® 0.5% in providing restful sensation to the eyes.
- Trial name
- NCT06373653
- Testing
- Manzanilla Sophia®, Meticel Ofteno®
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Avian Influenza
Evaluation of Priming Effects by PLAI Vaccine on the Subsequent Response to Inactivated H5N1 Vaccine
This study aim to compare immunogenicity of the inactivated H5 influenza vaccine single dose between subjects previously vaccinated with LAIV H5N2 and naïve subjects
- Trial name
- NCT02229357
- Testing
- OrniFlu® inactivated vaccine
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Smallpox, Poxvirus Infection
Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults
Primary Objective: To estimate the smallpox vaccination take rate in healthy young adults not previously vaccinated with a smallpox vaccine.
- Trial name
- NCT00258947
- Testing
- Smallpox vaccine, LISTER strain, from chick embryo cells
- Where
- 6 sites in France
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Sanofi
Mastitis
Global Effects of a Probiotic Strain on Lactating Women
In this study, the investigators will try to confirm if application of probiotic strains isolated from breast milk actually have a beneficial effect on women suffering lactational mastitis.
- Trial name
- PROBIOLAC (NCT01124448)
- Testing
- Lactobacillus salivarius PS2
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Digital Eye Strain (DES), Computer Vision Syndrome
Digital Eye Strain in Online Learning and Remote Work Environments: A Systematic Review
This systematic review aims to evaluate the prevalence of digital eye strain (DES) among individuals engaged in online learning and remote work, identify associated demographic, behavioral, environmental, and ocular risk factors…
- Trial name
- DES-OLRW (NCT07707908)
- Testing
- Systematic Literature Review
- Where
- Egypt
- Volunteers
- 8,972 people, healthy volunteers welcome
- Sponsor
- Benha University
Cardiac Output, Stroke Volume
Exercise Induced Plasma Volume Expansion Lowers Cardiovascular Strain
The goal of this observational study was to better understand the impact of increased plasma volume on later exercise in hypoxia. Investigators examined young, healthy, males who regularly participated in aerobic exercise.
- Trial name
- NCT05800808
- Testing
- High Intensity Intervals, Moderate Exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- California Baptist University