Clinical trials: Strain
Hyperthermia, Weather; Heat
Efficacy of Electric Fans for Mitigating Thermal Strain in Older Adults During Heat Waves
With the increasing regularity and intensity of hot weather and heat waves, there is an urgent need to develop heat-alleviation strategies able to provide targeted protection for heat-vulnerable older adults.
- Conditions
- Hyperthermia, Weather; Heat, Heat Stress, Aging
- Trial name
- NCT05695079
- Testing
- No cooling (control), Electric fan (low airflow), Electric fan (high airflow)
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Prepandemic Influenza Vaccine
Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H5N1) in Adult and Elderly Subjects
The present study will evaluate the immunogenicity, safety and tolerability of two doses of monovalent inactivated influenza vaccine that is adjuvanted with MF59C.1 (MF59) and uses a surface antigen from a potential pandemic…
- Trial name
- NCT00841646
- Testing
- Monovalent inactivated influenza vaccine
- Where
- 2 sites in Hungary
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Musculoskeletal Pain, Osteoarthritis
Clinical Outcomes of Autologous Bone Marrow Aspirate Concentrate Injections for Musculoskeletal Conditions
The use of Bone Marrow Autologous Collection (BMAC) in musculoskeletal conditions including osteoarthritis and tendon injuries has been growing. Outcome evidence continues to be sparse.
- Conditions
- Musculoskeletal Pain, Osteoarthritis, Tendinopathy, Sprains Strain
- Trial name
- NCT02981394
- Testing
- Bone Marrow Aspirate Concentrate Injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Stress, Psychological
Contribution of L-Tyrosine to Recovery From Operational Strain on Return From External Operation
Operational conditions amplify soldier's constraints and stress factors, upsetting individual and collective adaptive landmarks.
- Trial name
- USOP (NCT04549194)
- Testing
- Blood collection, L-Tyrosine 500 Mg, Psychological questionnaires
- Where
- France
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
SARS CoV-2 Infection, Elderly
Effect of the Consumption of a Lactobacillus Strain on the Incidence of Covid-19 in the Elderly
The objective of this trial is to evaluate the effect of the consumption of a probiotic strain on the incidence and severity of COVID-19 in elderly population living in a nursing home.
- Trial name
- NCT04756466
- Testing
- Lactobacillus
- Where
- 3 sites in Spain
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Body Temperature Changes, Heat Stress
Ambient Temperature and Thermoregulation During Exercise in Children and Youth
Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute…
- Conditions
- Body Temperature Changes, Heat Stress, Child Development, Heat
- Trial name
- NCT07781605
- Testing
- Exercise at 22°C, Exercise at 26°C, Exercise at 31°C
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress Disorders, Heat Stroke
Heat Strain Prevention in Elderly Agricultural Workers
The study explores a multi-component heat strain prevention program for older agricultural workers in response to climate change. It assesses hydration, rest breaks, reflective clothing, and shade provision.
- Conditions
- Heat Stress Disorders, Heat Stroke, Heat Exhaustion, Heat Cramps
- Trial name
- NCT06192069
- Testing
- Sustainable Heat Strain Prevention Program for Agricultural Elderly Workers (SHiP-AEW)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heat Stress, Physiological Stress
Physiological Strain in Older Adults During a Simulated Heat Wave
A recent report showed that maintaining indoor temperature at or below 26°C safeguards older, heat vulnerable adults against potentially dangerous increases in thermal and cardiovascular strain during an extreme heat event (PMID…
- Trial name
- NCT06633302
- Testing
- Simulated multi-day heatwave exposure
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Polio, Measles
the Five-year Antibody Persistence After Immunization With IPV, MMR and HepA-L Vaccines
This study evaluated the antibody persistence of Chinese children five years after they received four doses of sIPV, two doses of MMR vaccine and one dose of HepA-L vaccine.
- Conditions
- Polio, Measles, Rubella, Mumps
- Trial name
- NCT07338851
- Where
- 6 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
Heat Tolerance
Heat Stress and Physiological Strain of Permeable vs. Impermeable CB Protective Garment
Current protective clothing of any kind, especially the nuclear-biological-chemical (NBC) protective garments, amplify thermal stress because of the inherent properties of the clothing material.
- Trial name
- NCT01221012
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Oral Health
L. Brevis CD2 Strain Persistence in Oral Cavity
The aim of this study is to select the optimal conditions for quantification in the oral cavity of Lactobacillus brevis CD2, a probiotic strain contained in a commercially available dietary supplement and to assess its…
- Trial name
- NCT01782079
- Testing
- L. brevis
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Mastitis
Study of a Probiotic Strain to Prevent Mastitis and to Eradicate GBS Colonization
In previous studies, the investigators have seen that carefully-selected Lactobacillus strains are a good alternative to antibiotics for the treatment of lactational mastitis.
- Trial name
- PROBIOPREG (NCT01505361)
- Testing
- Lactobacillus salivarius PS2, Excipient (milk powder)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Cholera
A Phase 3 Lot to Lot Consistency Study of Live Oral Cholera Vaccine, PXVX0200 in Healthy Adults
The primary goal of this Phase III study is to compare 3 lots for consistency of manufacture.
- Trial name
- NCT02094586
- Testing
- PXVX0200 Lot A, PXVX0200 Lot B, PXVX0200 Lot C
- Where
- 25 sites in United States, Australia
- Volunteers
- 3,146 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Headache
Combine Effect Of Myofascial Release Technique and Ocular Muscle Exercise Among University Students
The current study aim to determine the effect of myofascial release technique and ocular muscle exercise to release eye strain headache in myopic students.
- Trial name
- NCT06406881
- Testing
- physical therapy, myofascial release therapy
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Mechanical Ventilation Complication
Determination of Normal Values of Regional Pulmonary Strain Using a New Ultrasonographic Tool in Healthy Volunteers
Mechanical ventilation is frequently used in the operating room and the intensive care settings. Although essential in many cases, mechanical ventilation can be responsible for ventilator-induced lung injury (VILI).
- Trial name
- Strain (NCT04194346)
- Testing
- Lung ultrasound
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Healthy
Phase I/II Safety and Immunogenicity of Pandemic Live Attenuated Influenza Vaccine (PLAIV) Candidate Strain A/17/CA/2009/38 (H1N1) in Healthy Thais
The purpose of this study is to evaluate safety and reactogenicity of Pandemic Live Attenuated Influenza Vaccine (PLAIV) manufactured by GPO, Thailand, and to evaluate humoral immune response of the above vaccine after intranasal…
- Trial name
- NCT01666262
- Testing
- Vaccine A/17/CA/2009/38 (H1N1)
- Where
- Thailand
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hyperthermia, Heat Stress
Efficacy of Ceiling Fans for Mitigating Thermal Strain During Bed Rest in Older Adults During Heat Waves
With the increasing regularity and intensity of hot weather and heat waves, there is an urgent need to develop heat-alleviation strategies able to provide targeted protection for heat-vulnerable older adults.
- Conditions
- Hyperthermia, Heat Stress, Cooling, Aging
- Trial name
- NCT06142890
- Testing
- No cooling (control), Cooling with ceiling fan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Myopia,, Hyperopia,
Refraction Determination Analysis
Correlating the accuracy of a refraction done over telemedicine to that of a standard refraction, with a study hypothesis that the results will be equivalent.
- Conditions
- Myopia,, Hyperopia,, Astigmatism,, Presbyopia,
- Trial name
- NCT01995435
- Testing
- Telemedicine refraction, Traditional refraction
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lee, Steven, M.D.
Glaucoma, Open-Angle
Optic Nerve Head Strain as Biomarker for Glaucoma
The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.
- Trial name
- NCT06240312
- Testing
- Images of eye at 2 eye pressures
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Influenza, Human
Phase 3 Safety and Immunogenicity Study of aQIV in Elderly Adults
This phase 3 study is a randomized, double-blinded, comparator controlled, parallel-group, multicenter study of aQIV versus the US-licensed 2017-2018 adjuvanted trivalent influenza vaccine (aTIV-1, Fluad), and versus an…
- Trial name
- NCT03314662
- Testing
- MF59-adjuvanted Quadrivalent Subunit Inactivated Egg-derived Influenza Vaccine (aQIV), Licensed MF59-adjuvanted Trivalent Subunit Inactivated Egg-derived Influenza Vaccine (aTIV-1), MF59-adjuvanted Trivalent Subunit Inactivated Egg-derived Influenza Vaccine Containing the Alternate B Strain (aTIV-2)
- Where
- 20 sites in United States
- Volunteers
- 1,778 people, healthy volunteers welcome
- Sponsor
- Seqirus