Clinical trials: Stratification
Familial Hypercholesterolemia, Atherosclerosis
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia
Familial hypercholesterolaemia (FH) is a genetic disorder characterised by elevated plasma LDLC levels. The causal role of low-density lipoprotein cholesterol (LDLC) in the progression of cardiovascular disease (CVD) is…
- Trial name
- CARDIOMET (NCT05066932)
- Testing
- Additionnal blood samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8
A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
This phase II trial compares the effect of using risk-based stratification to guide surgical management to the usual approach in treating cutaneous melanoma, atypical Spitz/Spitzoid tumors or other atypical melanocytic tumors…
- Conditions
- Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage II Cutaneous Melanoma AJCC v8, Cutaneous Melanocytic Neoplasm
- Trial name
- NCT07621614
- Testing
- Biospecimen Collection, Chest Radiography, Computed Tomography
- Where
- 13 sites in United States
- Volunteers
- 51 people
- Sponsor
- Children's Oncology Group
Covid19
Risk Stratification of Patients With Suspected COVID-19 Presenting to the ED
This project is an unfunded collaboration of approximately 30 emergency departments across Europe led by the EUSEM research network.
- Trial name
- EUROCOV (NCT04682093)
- Where
- 5 sites in Croatia, Finland and 3 more
- Volunteers
- 8,000 people
- Sponsor
- European Society for Emergency Medicine (EUSEM) Research Network
Implantable Loop Recorder
Bradycardia Risk Stratification With Loop Recorder After Syncope
Syncope is a common symptom that may be related to a conductive disorder. If no bradycardia is authenticated, it is often necessary to implant an implantable loop recorder.
- Trial name
- NCT04200014
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Brugada Syndrome, Cardiac Arrest
Feasibility of Improving Risk Stratification in Brugada Syndrome
Feasibility of Improving Risk Stratification in Brugada Syndrome (BrS), retrospective cohort study To study the reproducibility and specificity of V-CoS for activation heterogeneities predisposing to VT/VF in a larger series of…
- Conditions
- Brugada Syndrome, Cardiac Arrest, Athletes Heart, Atrial Fibrillation
- Trial name
- FIRST-BrS (NCT03992677)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Early Breast Cancer, Premenopausal Breast Cancer
Optimising Adjuvant Chemotherapy Prescription in Young Patients With Hormone-dependent Breast Cancer Using Genomic Tests
Rationale: Around 70 to 80% of breast cancers are so-called "hormone-dependent" (HR+)/HER2-. For more than 50 years, studies have shown that chemotherapy and optimised hormonal treatments (hormone therapy), including a drug…
- Conditions
- Early Breast Cancer, Premenopausal Breast Cancer, HR+/HER2- Breast Cancer
- Trial name
- OPTIMA-YOUNG (NCT07106632)
- Testing
- test-directed treatment: allocated treatment will depend on the PAM50 score result (centrally assessed) : chemo-endocrine therapy or endocrine therapy alone, In the control arm, the treatment will be as standard of care : chemo-endocrine therapy
- Where
- 105 sites in Belgium, France and 5 more
- Volunteers
- 3,380 people
- Sponsor
- UNICANCER
Myocardial Infarction
CCT for Comprehensive Risk Stratification Following STEMI
The CT-STEMI study aims to evaluate a comprehensive cardiac computed tomography (CCT) protocol for assessing the risk of heart failure (HF), life-threatening arrhythmias (LTA), and atherothrombotic events following ST-elevation…
- Trial name
- CT-STEMI (NCT06020209)
- Testing
- Cardiac Computed Tomography, Cardiac Magnetic Resonance
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Patient Fall
Evaluation of Balance and Movement in Order to Prevent the Risk of Falling in the Post-operative Period
This study aims to identify, in patients undergoing hip and knee joint replacement, the functional evaluation tools predictive of the risk of falling upon admission to the orthopedic department and to correlate the results…
- Trial name
- NOCADINRIAB (NCT05879315)
- Testing
- Fall risk prevention in hospital
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Major Depressive Disorder
Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR)
Selective serotonin reuptake inhibitors (SSRIs) raise serotonin (5-HT) in the synaptic cleft and are the current first line of pharmacological antidepressive treatment.
- Trial name
- NCT02711215
- Testing
- PET/MR [11C]DASB, Citalopram, Escitalopram (Mirtazapine/Duloxetine/Venlafaxine)
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Primary Prevention of Cardiovascular Disease
Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations
The goal of this clinical trial is to determine whether incorporating a polygenic risk score (PRS) can optimize primary cardiovascular disease prevention in individuals with intermediate cardiovascular risk.
- Trial name
- PERSONAL (NCT07039123)
- Testing
- Polygenic Risk Score for Coronary Artery Disease (PRS-CAD), Standardized Risk Communication Tool (SCORE2)
- Where
- 2 sites in Switzerland
- Volunteers
- 205 people
- Sponsor
- University of Bern
Depression
Effect of Minocycline on Inflammation in Depressed Patients
The study aims to evaluate or to assess: An improvement in the peripheral inflammatory levels in depressed patients after 8 weeks of treatment with Minocycline in addition to their current antidepressant treatment; Any…
- Trial name
- NCT06207760
- Testing
- Minocycline
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Human Immunodeficiency Virus
Evaluation of Problem Management Plus in Pregnant Women With HIV in Kenya
This study includes secondary quantitative analysis, qualitative methods, and hybrid type 2 implementation-effectiveness pilot trial.
- Trial name
- Tatua (NCT05841797)
- Testing
- In-Person Program Management Plus (PM+), Mobile Program Management Plus (mHealth PM+)
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Thyroid Nodule
The Diagnostic Value of Shear Wave Elastography
Background: The main goal when diagnosing thyroid nodules, is to differentiate the few malignant from the overwhelming background of benign nodules.
- Trial name
- NCT02150772
- Testing
- Shear Wave Elastography (SWE)
- Where
- Denmark
- Volunteers
- 308 people
- Sponsor
- University of Aarhus
Acute Pancreatitis (AP), News-2
Predictive Performance of NEWS-2 and NEWS-Calcium Scores for In-Hospital Mortality in Older Patients With Acute Pancreatitis
Acute pancreatitis is an important gastrointestinal emergency that may lead to mortality, particularly in older patients. This retrospective, single-center observational prognostic validation study aims to compare the predictive…
- Conditions
- Acute Pancreatitis (AP), News-2, Prediction of In-Hospital Mortality in Older Patients With Acute Pancreatitis
- Trial name
- NEWS (NCT07640971)
- Testing
- Retrospective Calculation of NEWS-2 Score
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people
- Sponsor
- Antalya Health Sciences University
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Patients Presenting With Suspicion of Infection to the ED
Risk Stratification Using Midregional Proadrenomedullin in the ED
Emergency departments (ED) are becoming increasingly over-crowded, with patients facing prolonged waiting times. Therefore, a safe and rapid assessment that identifies patients with low severity that could be treated as…
- Trial name
- NCT05108883
- Testing
- MR-proADM KRYPTOR
- Where
- 9 sites in France, Italy and 2 more
- Volunteers
- 463 people
- Sponsor
- Brahms AG
Melanoma (Skin Cancer)
ctDNA for Risk Stratification in Melanoma
This study examines circulating tumor DNA (ctDNA) as a biomarker in patients with primary melanoma, prior to surgical excision. The hypothesis is that ctDNA may be detectable in pre-operative blood samples from patients with…
- Trial name
- NCT07531121
- Where
- Denmark
- Volunteers
- 296 people
- Sponsor
- Herlev and Gentofte Hospital
Atherosclerosis, Hypercholesterolemia
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
Background: Atherosclerosis (thickening of the artery walls caused by cholesterol and other deposits) commonly occurs in the heart vessels and carotid (neck) arteries of adults.
- Trial name
- NCT01212900
- Testing
- Statins, HMG CoA
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Tumor
Characteristics of Cardiac Tumor and the Risk Stratification of Subsequent Adverse Events (UNIQUE)
This study aims to retrospectively and prospectively collect clinical and biological specimen data from patients with cardiac tumors who meet the inclusion and exclusion criteria.
- Trial name
- UNIQUE (NCT06100328)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University