Clinical trials: Stratification
Multiple Myeloma, Newly Diagnosed
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
This is a prospective, single-center, clinical study to evaluate the efficacy and safety of a fully immunotherapy-based strategy guided by MRD-driven dynamic risk stratification in transplant-ineligible patients with newly…
- Trial name
- CAREMM-008 (NCT07106736)
- Testing
- BCMA CAR-T, GPRC5D/CD3 BiTEs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Breast Cancer, Triple Negative Breast Cancer
Prospective Evaluation of AI R&D Tool for Patient Stratification - MoA Evaluation in Triple Negative Breast Cancer (PEAR-MET)
Pear Bio has developed an organ-on-a-chip device together with a computer vision pipeline through which the response of an individual patient's tumor to different systemic therapy regimens can be tested simultaneously ex vivo.
- Trial name
- PEAR-MET (NCT06182306)
- Testing
- Biopsy
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Ourotech, Inc.
Malnutrition, Intellectual Frailty of Aging
Omics4Aging: Stratification of Frailty Population
The overall objective of the study is to stratify a frailty population based on nutrients profiling (amino acids, vitamins, minerals, fatty acids) and metabolic profiling (low molecular weight metabolites in urine and plasma) at…
- Conditions
- Malnutrition, Intellectual Frailty of Aging, Bone Fragility
- Trial name
- ProAge (NCT02572063)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Société des Produits Nestlé (SPN)
BRCA1 Mutation, BRCA2 Mutation
Magnetic Resonance Breast Tissue Characterisation to Improve Risk Stratification for Breast Cancer
This is a combination retrospective/prospective observational study with two arms:
- Conditions
- BRCA1 Mutation, BRCA2 Mutation, Mammography, MRI
- Trial name
- MR-BTC (NCT03684733)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Esophageal Cancer, Gastric Cancer
Effectiveness of Risk-based Sequential Screening for Esophageal and Gastric Cancer
To evaluate the feasibility, applicability, effectiveness, and health-economic value of the risk-based sequential screening modality for esophageal and gastric cancers, the investigators aim to initiate a community-based…
- Conditions
- Esophageal Cancer, Gastric Cancer, Precision Screening, Sequential Screening
- Trial name
- ERSS-EGC (NCT06306755)
- Testing
- Risk Assessment and Individualized Surveillance, Universal screening
- Where
- China
- Volunteers
- 21,000 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Heart Failure, CAD - Coronary Artery Disease
Risk Stratification of MACE in Heart Failure Patients Who Undergoing CABG
PROFILE-HF is a multicenter, observational, prospective study of the clinical course and outcomes of chronic heart failure (HF) and coronary artery disease (CAD) in patients undergoing coronary artery bypass grafting (CABG).
- Conditions
- Heart Failure, CAD - Coronary Artery Disease, CABG
- Trial name
- PROFILE-HF (NCT07480915)
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Malnutrition-Inflammation Syndrome, Hemodialysis Nutritional Risk Stratification
Validity and Reproducibility of OSND (Objective Score of Nutrition on Dialysis) as a Nutritional Marker in End-stage Renal Disease
This prospective observational study is planned to validate OSND against the prospective morbidity and mortality in chronic hemodialysis patients and to examine the hypothesis that OSND risk stratification of chronic HD patients…
- Trial name
- NCT01214447
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Assaf-Harofeh Medical Center
Sjögren´s Syndrome
Primary Sjögren's Syndrome: Impact of Quantitative Anti-Ro52 Antibody Analysis on Patient Prognosis and Stratification (Ro-SjS)
This study aims to evaluate the prognostic value of quantitative anti-Ro52 antibody levels in patients with primary Sjögren's Syndrome.
- Trial name
- Ro-SjS (NCT07414667)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Central Hospital, Nancy, France
Indeterminate Pulmonary Nodule
Nodify Lung Testing for Pulmonary Nodules
The STRATIFY Study is an observational study for adults age 40 or older who have a lung nodule that is not clearly benign or cancerous. The study will enroll up to 1,000 participants at about 10-12 U.S.
- Trial name
- STRATIFY (NCT07858552)
- Volunteers
- 1,000 people
- Sponsor
- Biodesix, Inc.
Acute Coronary Syndrome, Chest Pain
Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin
The broad, long-term objective is to improve outcomes by optimizing healthcare delivery processes for patients with detectable to elevated serum troponin.
- Trial name
- CMR-IMPACT (NCT01931852)
- Testing
- Cardiac MRI, ACC/AHA Guideline adherent care
- Where
- 4 sites in United States
- Volunteers
- 312 people
- Sponsor
- Wake Forest University Health Sciences
Juvenile Idiopathic Arthritis
Clinical, Laboratory and Ultrasound Stratification of Patients With Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis (JIA), the most common rheumatologic chronic disease in children, is defined as arthritis persisting for at least 6 weeks with no known cause in a patient under the age of 16.
- Trial name
- NCT06007456
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Burlo Garofolo
ICAS - Intracranial Atherosclerosis, Stroke Ischemic
MPR for Stroke Risk Assessment of ICAS
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve…
- Conditions
- ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic
- Trial name
- NCT07309718
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
Study on the Incremental Predictive Value of Early Resting-State EEG Phenotypes for Functional Prognosis and Risk Stratification in Acute Ischemic Stroke
This is a single-center, prospective, observational cohort study that plans to consecutively enroll 400 patients with acute ischemic stroke from July 2026 to July 2029.
- Trial name
- NCT07741669
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Renal Insufficiency, Chronic
To Investigate Pharmacokinetics (Absorption, Distribution, Elimination), Safety and Tolerability of a Single Oral Dose of 75 mg Molidustat Tablet in Male and Female Subjects Requiring Hemo- or Peritoneal Dialysis Compared to Healthy Subjects
The study investigates the pharmacokinetics (absorption, distribution, elimination) of molidustat after intake of a single 75 mg tablet in subjects with renal impairment requiring hemo- or peritoneal dialysis compared to age-and…
- Trial name
- NCT02312973
- Testing
- Molidustat(BAY85-3934)
- Where
- 2 sites in Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bayer
Colorectal Cancer
Study of Bevacizumab + mFOLFOX6 Versus Bevacizumab + FOLFIRI With Biomarker Stratification in Participants With Previously Untreated Metastatic Colorectal Cancer (mCRC)
This will be a randomized, open-label, multicenter, Phase II study with primary objectives to assess whether expression of select chemotherapy markers is associated with progression-free survival (PFS) in participants treated…
- Trial name
- MAVERICC (NCT01374425)
- Testing
- 5-Fluorouracil, Bevacizumab, Irinotecan
- Where
- 79 sites in United States, Canada and 5 more
- Volunteers
- 376 people
- Sponsor
- Genentech, Inc.
Post-transplant Lymphoproliferative Disorder
Polatuzumab Vedotin (Pola) Plus Rituximab (R) in Patients With Post-transplant Lymphoproliferative Disorder (PTLD)
This study will test polatuzumab vedotin in combination with rituximab in patients with treatment-naïve CD20-positive post-transplant lymphoproliferative disorder (PTLD) based on the established efficacy of polatuzumab vedotin in…
- Trial name
- NCT06040320
- Testing
- Polatuzumab vedotin, Rituximab, CHP
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
Liver Cirrhosis, Portal Hypertension
HVPG for Rebleeding Risk Stratification
Background: In patients with cirrhosis on secondary prevention of variceal rebleeding with non-selective beta-blockers (NSBBs), the risk of rebleeding and death is markedly higher in those failing to achieve a good hemodynamic…
- Trial name
- NCT01751191
- Where
- 2 sites in Spain
- Volunteers
- 338 people
- Sponsor
- Hospital Clinic of Barcelona
Epigenetics, DNA Methylation
Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening
The MET-SELS study aims to revolutionize how we identify individuals for lung cancer screening by moving beyond the limitations of self-reported smoking history.
- Conditions
- Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker
- Trial name
- MET-SELS (NCT07631624)
- Testing
- DNA-methylation in saliva
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Myocardial Infarction, Arrhythmia, Ventricular
MASTER I - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients
The purpose of the study is to determine the usefulness of microvolt T wave alternans (MTWA) testing of patients that have had a heart attack and have decreased pumping ability of the lower chamber of their heart.
- Conditions
- Myocardial Infarction, Arrhythmia, Ventricular, Ischemic Cardiomyopathy
- Trial name
- NCT00305240
- Testing
- T Wave Alternans Test
- Where
- 47 sites in United States
- Volunteers
- 656 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure