Clinical trials: Stratification
Experts in Physical Activity Prescription and Risk Health Screening
Expert Validation of an Autonomous Personalized Physical Activity Algorithm
This study aims to validate a personalized physical activity algorithm for risk screening and individualized exercise prescription using a modified online Delphi process.
- Trial name
- APPA e-Delphi (NCT07475221)
- Where
- Portugal
- Volunteers
- 9 people
- Sponsor
- Polytechnic Institute of Porto
Non-Alcoholic Fatty Liver Disease
FCI Effectiveness in NAFLD Stratification
The goal of this pilot study is exploring whether field-cycling imaging may be able to detect characteristics of liver disease in patients with different degree of non-alcoholic fatty liver disease (NAFLD) that could be important…
- Trial name
- FIELDS (NCT05827432)
- Testing
- Field-cycling imaging (FCI)
- Where
- United Kingdom
- Sponsor
- NHS Grampian
Sickle Cell Disease, Sickle Cell Anemia
Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia.
- Trial name
- NCT02149537
- Testing
- hydroxyurea
- Where
- Nigeria
- Volunteers
- 53 people
- Sponsor
- Loyola University
Rhabdomyosarcoma
Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease
This is a phase II study to determine safety and efficacy of combining liposomal irinotecan with vincristine alternating with VAC in intermediate-risk patients, liposomal irinotecan with temozolomide and vincristine alternating…
- Trial name
- NCT06023641
- Testing
- Vincristine, Dactinomycin, Cyclophosphamide
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer, Mammographic Breast Density
PERsonalized Mammographic Screening in Norway
The aim of this study is to assess attendance among women invited to additional breast imaging because they were identified as having an increased risk of breast cancer at screening.
- Conditions
- Breast Cancer, Mammographic Breast Density, Risk Stratification
- Trial name
- PERMS (NCT07371702)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Intrahepatic Cholangiocarcinoma (Icc)
Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.
Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking.
- Trial name
- EXOMIC (NCT07224737)
- Testing
- EXOMIC small RNA sequencing, EXOMIC assay (qRT-PCR validation)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Back Pain
Matching Appropriate Treatments to Consumers' Healthcare Needs, MATCH
Back pain is one of the most common, controversial and costly problems in healthcare. Despite numerous studies, care for back pain has deteriorated over time and become much more expensive.
- Trial name
- MATCH (NCT02286141)
- Where
- United States
- Volunteers
- 1,760 people
- Sponsor
- Kaiser Permanente
Patients Presenting With Suspicion of Infection to the ED
Risk Stratification Using Midregional Proadrenomedullin in the ED
Emergency departments (ED) are becoming increasingly over-crowded, with patients facing prolonged waiting times. Therefore, a safe and rapid assessment that identifies patients with low severity that could be treated as…
- Trial name
- NCT05108883
- Testing
- MR-proADM KRYPTOR
- Where
- 9 sites in France, Italy and 2 more
- Volunteers
- 463 people
- Sponsor
- Brahms AG
Vulvar Squamous Cell Carcinoma
STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision
This study is being done to answer the following question: Are there types of early-stage vulvar cancer that require either less or more treatment than the usual approach?
- Trial name
- STRIVE (NCT06358469)
- Testing
- Surgery, Active Surveillance
- Where
- 12 sites in Canada, New Zealand
- Volunteers
- 249 people
- Sponsor
- Canadian Cancer Trials Group
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Upper Gastrointestinal Bleeding
Risk Stratification of Patients Presenting With Upper Gastrointestinal Bleeding to the Emergency Department Using AIMS65 Score and Red Cell Distribution Width
The rationale of this study in UGIB patients is to assess whether the prediction of mortality and morbidity using AIMS65 score improves when used in combination with RDW in the emergency department setting.
- Trial name
- RUGBE (NCT04825977)
- Testing
- RISK STRATIFICATION USING AIMS65 SCORE AND RDW
- Where
- India
- Volunteers
- 348 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Colorectal Cancer
Prognosis Stratification for pT4bN0M0 Colorectal Cancer Following Multivisceral Resection
The purpose of this study was to identify the prognostic factors of affecting pT4bN0M0 colorectal cancer patients, so as to better stratify the prognostic differences among patients with the same stage.
- Trial name
- NCT06115837
- Testing
- multivisceral resection
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Ovarian Cancer
CADx - Radiomics to Distinguish the Origin of Ovarian Tumors
In women with an ovarian tumor, it is often unclear whether the tumor is benign or malignant. To differentiate, tumor markers (CA125 and CEA), a transvaginal ultrasound and, depending on the ultrasound image and the CA125…
- Trial name
- CADx (NCT05174377)
- Testing
- CT-scan algorithm
- Where
- 5 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- Gynaecologisch Oncologisch Centrum Zuid
Acute Respiratory Failure (ARF), Intermediate Respiratory Care Unit
BELLRICU PROJECT: Precision Medicine in Respiratory Intermediate Care Units
A respiratory intermediate care unit (RICU) is a monitoring and treatment area of respiratory patients who do not required admission to intensive care unit (ICU) but due to complexity, they could not be managed in conventional…
- Conditions
- Acute Respiratory Failure (ARF), Intermediate Respiratory Care Unit, Respiratory Precision Medicine, Mortality Prediction
- Trial name
- BELLRICU (NCT07644637)
- Where
- Spain
- Volunteers
- 624 people
- Sponsor
- Hospital Universitari de Bellvitge
Coronary Artery Disease, Myocardial Infarction
Myocardial Infarction Genes (MI-GENES) Study
This study is being done to better understand how genetic information might improve assessment of heart attack risk.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Genomic Risk Communication
- Trial name
- MI-GENES (NCT01936675)
- Testing
- Genetic Risk Score
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Fluid Volume Disorder
Risk Stratification and Goal-directed Volume Therapy
It is difficulte to evaluate risk patients and to find the ideal intraoperative volume management. It seems to be that ill patients benefit of a goal directed volume management.
- Trial name
- NCT01456702
- Testing
- risk stratification group
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Hypertrophic Cardiomyopathy
Extended Ambulatory Monitoring Improves Risk Stratification in Hypertrophic Cardiomyopathy
Eligible subjects will wear 4 consecutive external monitoring devices for a total of 28 days of monitoring.
- Trial name
- NCT03182153
- Testing
- Extended Cardiac Monitoring
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Atlantic Health System
Gastric Cancer (GC)
Development and Validation of the Surgical Assessment and Healthcare (SAH) Index for Gastric Cancer Treatment Evaluation
This study develops the Surgical Assessment and Healthcare (SAH) Index, a new tool to fairly evaluate gastric cancer surgery outcomes.
- Trial name
- SAH (NCT07180966)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Ruijin Hospital
Overweight or Obesity, Physical Activities
An Innovative Care Model Integrating Mobile Health Support to Promote Weight Management in Adults With Overweight or Obesity
The objective of this clinical trial is to evaluate whether an innovative care model integrating mobile health (mHealth) support improves weight management in adults with overweight or obesity.
- Conditions
- Overweight or Obesity, Physical Activities, Healthy Diet, Weight Change
- Trial name
- NCT06996431
- Testing
- EMA-based weight management intervention, Minimal Intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 876 people
- Sponsor
- The University of Hong Kong