Clinical trials: Stratification
Extranodal Natural Killer/T-cell Lymphoma
A Clinical Study of the Value of Circulating Free Methylated EBV DNA in Extranodal NK/T Cell Lymphoma
This study is a prospective, multicenter, open-label, single-arm clinical study. This study plans to enroll 72 newly diagnosed ENKTCL patients. The enrollment was completed in 2 years, and the follow-up was terminated in 4 years.
- Trial name
- NCT05343377
- Testing
- circulate free methylated EBV DNA
- Where
- China
- Volunteers
- 72 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Arrhythmogenic Cardiomyopathy
Risk Stratification, Early Prevention and Treatment Strategies for Arrhythmogenic Cardiomyopathy
This study will include patients diagnosed with Arrhythmogenic cardiomyopathy (ACM) in the First Affiliated Hospital of Xi 'an Jiaotong University and other centers, and collect clinical data and biological samples of patients…
- Trial name
- STARTER (NCT06352307)
- Testing
- Diagnosis of ACM
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Penicillin Allergy
Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic.
- Trial name
- NCT04441021
- Testing
- Penicillin Allergy Risk Stratification and Evaluation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Myelodysplastic Syndromes, Adult
Prophylactic Intervention for Relapse Prevention Post-Allogeneic Transplantation in Very High-Risk MDS Patients Based on IPSS-M Stratification
By collecting interventional clinical data to assess the survival and relapse conditions of patients post-transplantation and comparing them with historical data, the primary study endpoint is the 1-year and 2-year relapse-free…
- Trial name
- NCT06612944
- Testing
- Prophylactic Intervention for Relapse Prevention Post-Allogeneic Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Kidney Transplant Failure
Human Versus Computer-based Predictions of Long Allograft Survival
The clinical decision-making after kidney transplantation is mainly driven by patient individual assessment. However, this task remains difficult and uncertain due to the integration of complex and numerous parameters.
- Trial name
- iBox vs Human (NCT04918199)
- Testing
- Computer based assessment (iBox), Physician assessement
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Pain, Intractable
Identification of Outcome Predictors and Stratification of Responder Profiles Implanted With Spinal Cord Stimulation. An AI-based-pathway & Algorithmic Approach to Treat Failed Back Surgery Syndrome Patients
Failed Back Surgery Syndrome is commonly defined as new, recurrent, or persistent pain in the back and/or leg(s) of at least 6-month duration following spinal surgery.
- Trial name
- PREDIBACK 2 (NCT04587674)
- Testing
- Spinal Cord Stimulation
- Where
- 7 sites in France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
Leukemia, Lymphoma
Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies can locate cancer cells and either kill them or deliver cancer-killing substances to…
- Trial name
- NCT00049413
- Testing
- rituximab, cyclophosphamide, pentostatin
- Where
- United States
- Sponsor
- Hoag Memorial Hospital Presbyterian
Idiopathic Pulmonary Fibrosis
Validation of the Risk Stratification Score in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and a considerable variability in the disease's natural history.
- Trial name
- NCT02632123
- Where
- 2 sites in Canada, Italy
- Volunteers
- 260 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke, Ischemic, Cardiovascular Risk Factor
Development of a Prognostic Tool for the Stratification of Cardiovascular Risk in Patients With Ischemic Stroke
The availability of several high-cost strategies for the prevention of cardiovascular morbidity and mortality in patients with established cardiovascular disease highlights the necessity of reliable risk stratification of these…
- Conditions
- Stroke, Ischemic, Cardiovascular Risk Factor, Cardiovascular Diseases, Cardiovascular Morbidity
- Trial name
- NCT04189497
- Where
- Greece
- Volunteers
- 3,500 people
- Sponsor
- University of Thessaly
Myocardial Infarction Postoperative, Myocardial Injury
Preoperative BNP: Epidemiological Patterns, Management Strategies and Cost Analysis of Care
Recently, the use of preoperative BNP as a preoperative risk stratifcation tool was added to the Canadian Cardiovascular Society (CCS) guidelines (4) on perioperative cardiac risk assessment and management for patients who…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Death, Cardiac
- Trial name
- NCT04077294
- Testing
- Cardiac risk stratification using preoperative BNP measurement, followed by postoperative cardiac monitoring, Use of traditional perioperative cardiac risk stratification only
- Where
- Canada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Thyroid Nodule, Follicular Neoplasm
Diagnostic Accuracy of Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular Lesions of the Thyroid
As many as 70-85% subjects diagnosed with a follicular lesion on biopsy and undergoing surgery will have benign lesions verified by histopathology after surgery.
- Trial name
- NCT03106337
- Testing
- Shear-Wave Elastography
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Coronary Atherosclerosis Disease Early Identification and Risk Stratification by Noninvasive Imaging
The investigator prospectively enroll 30,000 outpatients who were suspected of coronary artery disease (CAD) and underwent cardiac computed tomography angiography (CTA).
- Trial name
- Creation (NCT03518437)
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Prostate Cancer
Exploiting Risk-Based Risk Stratification in Early Prostate Cancer to Discriminate Progressors From Non-Progressors
This study seeks to analyse MRI images and biological samples from 60 men diagnosed as having intermediate risk prostate cancer at baseline and one year afterwards to compare the molecular, genetic and transcriptomic differences…
- Trial name
- RECONCILE (NCT04340245)
- Testing
- NA (Observational)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Lung Cancer Non Small Cell
Comprehensive Demographics and Clinical Profile of NSCLC Patients
Advances in the treatment of non-small cell lung cancer in the last decade have been significant. Currently, there are several first-line therapeutic options.
- Trial name
- CA209-1529 (NCT06725537)
- Volunteers
- 500 people
- Sponsor
- D'Or Institute for Research and Education
Cervical Cancer, Radiotherapy
A Predictive Model for Early Metastasis in Cervical Cancer Patients After Radiotherapy
This study aims to help to screen out appropriate cases for consolidation therapy and more intensive follow up.
- Conditions
- Cervical Cancer, Radiotherapy, Distant Metastasis, Prognostic Model
- Trial name
- NCT06101966
- Testing
- external pelvic beam radiotherapy (EBRT) followed by individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Cancer Hospital
Covid19, Cardiovascular Risk Factor
Cardiovascular Risk Stratification in Covid-19
This retrospective double-cohort study seeks to: 1. Describe the cardiovascular manifestations and electrophysiological (EP) substrate in COVID-19 infection and their association with clinical outcomes; and 2.
- Trial name
- CaVaR-Co19 (NCT04555187)
- Where
- United States
- Volunteers
- 1,355 people
- Sponsor
- Oregon Health and Science University
Heart Failure, Morality
Optimized Peak VO2 in Predicting Advanced HF
The ability and timely selection of severe heart failure (HF) patients for cardiac transplantation and advanced HF therapy is challenging. Peak VO2 by cardiopulmonary exercise test (CPET) was used for transplant listing.
- Conditions
- Heart Failure, Morality, Transplant; Failure, Heart
- Trial name
- NCT05212649
- Testing
- cardiopulmonary exercise test
- Where
- Taiwan
- Volunteers
- 377 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Pain, Emergencies
Machine Learning for Risk Stratification in the Emergency Department (MARS-ED)
Rationale Identifying emergency department (ED) patients at high and low risk shortly after admission could help decision-making regarding patient care.
- Trial name
- MARS-ED (NCT05497830)
- Testing
- RISK-INDEX
- Where
- Netherlands
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sudden Infant Death, Sudden Unexplained Infant Death
Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome
This is a multicenter genetic study aimed at identifying new genes/variants associated with sudden infant death syndrome (SIDS) based on whole-genome sequencing of family trios
- Trial name
- BIOMINRISK (NCT06244433)
- Testing
- whole genome sequencing
- Where
- 18 sites in France
- Volunteers
- 650 people
- Sponsor
- Nantes University Hospital
Autoimmune Hepatitis
AIH Risk Stratification With Multiparametric MRI
The primary aim of this study is to investigate whether the baseline cT1 can predict those whose condition relapses following treatment withdrawal.
- Trial name
- NCT04339621
- Testing
- LiverMultiscan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Perspectum