Clinical trials: Stratification
Myocardial Infarction, Arrhythmia, Ventricular
MASTER II - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients
The purpose of the study is to determine the usefulness of Microvolt T Wave Alternans (MTWA) testing of patients that have had a heart attack and have decreased pumping ability of the lower chamber of their heart.
- Conditions
- Myocardial Infarction, Arrhythmia, Ventricular, Ischemic Cardiomyopathy
- Trial name
- NCT00305214
- Testing
- T Wave Alternans Test
- Where
- 47 sites in United States
- Volunteers
- 405 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Acute Disease, Emergencies
Implementation of the Individual Danish Emergency Process Triage
The purpose of the study is to implement and evaluate a novel triage algorithm for risk stratification of acutely admitted patients in the Emergency Department.
- Conditions
- Acute Disease, Emergencies, Clinical Syndrome
- Trial name
- I-DEPT (NCT04571021)
- Testing
- I-DEPT, DEPT
- Where
- 8 sites in Denmark
- Volunteers
- 250,000 people
- Sponsor
- Herlev Hospital
Hyperkalaemia
AI-Enabled ECG Stratification and Timing of Potassium-Lowering Therapy in Patients With Hyperkalemia: A Target Trial Emulation Study
Hyperkalemia is a common and potentially life-threatening electrolyte disorder, yet there is limited evidence guiding the optimal timing of potassium-lowering therapy in routine clinical practice.
- Trial name
- AIDE-K (NCT07307729)
- Testing
- Timely treatment, Delayed treatment
- Volunteers
- 5,000 people
- Sponsor
- National Defense Medical Center, Taiwan
Prostate Cancer
Radiomics of Treatment-naive Prostate Cancer Patients on Multiparametric MRI for Risk Stratification and Treatment Outcomes Predictions
Prostate cancers (PCA) are a heterogeneous group which include indolent tumors that has no clinical significance to very aggressive cancer that could result in morbidities and mortality.
- Trial name
- NCT06126172
- Testing
- Multiparametric magnetic resonance imaging (mpMRI)
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- Chang Gung Memorial Hospital
Platelet Function Tests, Predictive Value of Tests
Risk Stratification Post TAVI Using TEG
Transcatheter aortic valve implantation (TAVI) has become the standard of care in elderly patients at increased risk for surgical aortic valve replacement . However, the optimal antithrombotic strategy post TAVI is still unclear.
- Conditions
- Platelet Function Tests, Predictive Value of Tests, Thrombelastography, Cardiovascular Diseases
- Trial name
- RISTRATAVI (NCT03649594)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Torben Pottgiesser
Prostate Cancer, Head and Neck Cancer
Predictors of Normal Tissue Response From the Microenvironment in Radiotherapy for Prostate and Head-and-neck Cancer
The main idea behind MICRO-LEARNER is to provide new insights about the response of healthy tissues to radiation by using information from the micro-environment obtained by biological measurements and imaging.
- Trial name
- MICROLEARNER (NCT03294122)
- Testing
- External beam radiotherapy for prostate cancer, External beam radiotherapy for head and neck cancer
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Isolated Noncompaction of the Ventricular Myocardium
Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)
This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients.
- Trial name
- NCT06504056
- Testing
- Diagnosis of NVM
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Arthritis
Early STratification of Acute ARThritis
The prospective observational study "Early STratification of acute inflammatory ARThritis" (START) aims to build a platform for identification of markers for early stratification of inflammatory arthritis to ensure timely…
- Trial name
- START (NCT07106931)
- Testing
- This is an observational study with no intervention
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Diakonhjemmet Hospital
Prostate Cancer
Exploiting Risk-Based Risk Stratification in Early Prostate Cancer to Discriminate Progressors From Non-Progressors
This study seeks to analyse MRI images and biological samples from 60 men diagnosed as having intermediate risk prostate cancer at baseline and one year afterwards to compare the molecular, genetic and transcriptomic differences…
- Trial name
- RECONCILE (NCT04340245)
- Testing
- NA (Observational)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Myocardial Ischemia, Acute Coronary Syndrome
Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement
The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk…
- Conditions
- Myocardial Ischemia, Acute Coronary Syndrome, Myocardial Infarction, Coronary Occlusion
- Trial name
- MyRiAD (NCT00657436)
- Where
- Switzerland
- Volunteers
- 403 people
- Sponsor
- University of Zurich
Chronic Renal Disease, Diabetic Foot
Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
Context and hypothesis: The prevalence of diabetes mellitus keeps going to increase, due to the ageing of the population and the high prevalence of overweight and obesity.
- Trial name
- NEPHROPOD (NCT04100551)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Prostate Cancer (Diagnosis), Clinically Significant Prostate Cancer
Multimodal Imaging and Digital Pathology for Prostate Cancer Prediction
This is a multicenter observational study. A deep learning model integrated with multimodal imaging and digital pathology spatial registration is built based on preoperative multiparametric magnetic resonance imaging, transrectal…
- Trial name
- NCT07614256
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangxi Medical University
Rheumatoid Arthritis
Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification
The main aim of the study is to determine the clinical utility of naive T-cell stratification for rationalising treatment with methotrexate (MTX), for DMARD-naive early RA patients.
- Trial name
- TEEMS (NCT03813771)
- Testing
- Benepali, Sulfasalazine, Methotrexate
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Leeds
Acute Pain, Emergencies
Machine Learning for Risk Stratification in the Emergency Department (MARS-ED)
Rationale Identifying emergency department (ED) patients at high and low risk shortly after admission could help decision-making regarding patient care.
- Trial name
- MARS-ED (NCT05497830)
- Testing
- RISK-INDEX
- Where
- Netherlands
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Non Ischemic Cardiomyopathy
Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronisation Therapy
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk…
- Trial name
- MADURAI CRT (NCT07791407)
- Testing
- left bundle branch pacing, Biventricular pacing with defibrillator
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Velammal Medical College Hospital and Research Institute
Renal Injury, Acute
Acute Kidney Injury : Long-term Renal and Cardiovascular Prognosis and Biomarker-based Risk Assessment
Patients who develop severe acute kidney injury (AKI) in intensive care remain at increased long-term risk of mortality, major cardiovascular events, and chronic renal complications, including prolonged dependence on renal…
- Trial name
- AKIRA (NCT07596407)
- Where
- France
- Volunteers
- 412 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventricular Arrhythmias, Cardiac Death
Evaluation of Novel Biomarkers to Improve Risk Stratification and Patient Selection in Implantable Cardioverter-defibrillator (ICD) Therapy
Implantable cardioverter-defibrillator (ICD) therapy reduces mortality in patients with chronic heart failure and reduced left ventricular ejection fraction (LVEF) <36%.
- Trial name
- BIOMARKERICD (NCT01594073)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Hannover Medical School
Renal Insufficiency, Acute
Determination of the "Tissue Transit Time" (TTT)
Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty
- Trial name
- NCT03311256
- Testing
- Tissue Transit Time
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 119 people
- Sponsor
- University Hospital Tuebingen
Population Health Management, Patient Navigation
AI-Supported Care Engagement for Next-step Delivery - Medicare Advantage
ASCEND-MA is an embedded, health-services study of at-risk Medicare Advantage members attributed to Intermountain Health in Utah.
- Trial name
- ASCEND-MA (NCT07804095)
- Testing
- AI-Supported Rising-Risk Care Navigation
- Where
- United States
- Volunteers
- 9,906 people
- Sponsor
- Intermountain Health Care, Inc.
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer