Clinical trials: Stress Disorder, Post-Traumatic
Bereavement
Family-authored Digital ICU Diary Intervention to Support Bereaved Family Members in Intensive Care Unit: A Pilot Mixed Methods Study
Objectives: To assess the feasibility, acceptability and appropriateness of a family-authored digital ICU diary intervention for bereaved family members in Hong Kong ICUs, and to explore family members' experiences of writing…
- Trial name
- ICU-Diary-HK (NCT07788768)
- Testing
- Family-authored Digital ICU Diary Intervention, Standard Care
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Depression, Anxiety
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid…
- Conditions
- Depression, Anxiety, PTSD, Family Dynamics
- Trial name
- NCT06261463
- Testing
- CAFES2
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Illinois Chicago
PTSD
Psycho-educational Tool to Prevent Psychological Sequelae Following Paediatric Intensive Care Unit Admission
To systematically evaluate an innovative directed psycho-educational intervention consisting of written specific, age-appropriate information, complemented by a follow-up targeted telephone call in order to reduce psychological…
- Trial name
- 4PICU (NCT04635449)
- Testing
- Age-specific information booklet and targeted telephone call
- Where
- United Kingdom
- Volunteers
- 288 people
- Sponsor
- Imperial College Healthcare NHS Trust
Perinatal Loss, Perinatal Grief
The Effect of Nursing Care With Peri-Natal Loss
This study was planned to evaluate the effect of standardised nursing care given to women with perinatal loss using the nursing process on perinatal grief, posttraumatic stress and postpartum depression.
- Trial name
- NCT06896214
- Testing
- Standardised nursing care intervention
- Volunteers
- 58 people
- Sponsor
- Gazi University
Stress Disorders, Post-traumatic
Analyzing Female Trauma Exposed Responses to a Medication
This purpose of this study is to look at the safety of the experimental drug GSK561679 as well as its effects on PTSD symptoms, thinking and memory, startle reaction, stress hormones, and mental health symptoms in comparison to…
- Trial name
- AFTER (NCT01814332)
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder PTSD
Effectiveness of Informational and Educational Tools to Improve the Experience of Relatives of ICU Patients. RELIEF, a Platform Trial
The admission of a patient to an intensive care unit (ICU) is associated with high levels of acute stress, anxiety, and depression among relatives, as well as extreme emotions such as fear, guilt, distress, and helplessness.
- Trial name
- RELIEF (NCT06851884)
- Testing
- Standard of Care (SOC), Video capsules, Cartoon
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Carcinoma, Post Traumatic Stress Disorder
Psychological Care of Oncology Patients With Post-traumatic Stress in the Context of a COVID-19
In the context of the COVID-19 pandemic, concerns of the risk of infection may lead to fear, anxiety or psychological disorders that may become generalised and long-lasting, corresponding to post-traumatic stress disorder (PTSD).
- Conditions
- Solid Carcinoma, Post Traumatic Stress Disorder, Covid19
- Trial name
- COVIPACT 2 (NCT04747249)
- Testing
- Psychological support
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Francois Baclesse
Intrusive Memories of Trauma, Symptom of Post Traumatic Stress Disorder (Criterion B1)
A Brief Cognitive Intervention After Intrusive Memories of Trauma With Young Refugees
This research study is designed to investigate the use of a simple cognitive task (a memory cue and 10 minute time gap, followed by playing the computer game "Tetris") for decreasing the number of intrusive memories of trauma…
- Trial name
- NCT03525158
- Testing
- Brief cognitive intervention
- Where
- 2 sites in Sweden
- Volunteers
- 4 people
- Sponsor
- Karolinska Institutet
Major Depressive Disorder (MDD, Anxiety Disorder, Generalized
Serotonin Variants & Gut Microbiota in Mental Health
This observational pilot study investigates whether a broad panel of genetic variants relevant to the serotonin pathway (including serotonergic system, methylation cycle, intestinal barrier integrity, and inflammatory response…
- Conditions
- Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder
- Trial name
- NCT07634458
- Testing
- SNP Genotyping and Gut Metagenomics
- Volunteers
- 30 people
- Sponsor
- Neurobiologix
Major Depression
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S.
- Trial name
- PIVOT (NCT07226232)
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
PTSD
Prevention of Combat-related PTSD Using Attention Bias Modification (ABM): A Randomized Controlled Trial
Military deployment to combat zones involves exposure to trauma at a higher than average rate and therefore presents a unique opportunity to study predisposing factors to posttraumatic stress reactions and test strategies…
- Trial name
- NCT01723215
- Testing
- Active ABMT8, Active ABMT4
- Where
- Israel
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
PTSD
Optimizing Treatment Response in VA Specialized Intensive/Inpatient PTSD Programs
Prolonged Exposure therapy (PE) is a first-line treatment for posttraumatic stress disorder; however few VA patients receive this treatment.
- Trial name
- NCT03533608
- Testing
- Group PE
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development
PTSD
7-Keto DHEA for the Treatment of PTSD
The purpose of this research study is to test the effectiveness of 7-Keto DHEA in reducing symptoms of Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01861847
- Testing
- 7-Keto Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Humanetics Corporation
Acceptability of Health Care
Blended Treatment för PTSD Feasibility Study
Feasibility and pilot study using within-group design with the aim of examining whether the blended psychological treatment for PTSD is acceptable for patients and therapists. 20 patients will be included and 4 therapists.
- Trial name
- NCT04881643
- Testing
- Trauma-focused cognitive behavioural therapy via a digital support
- Where
- Sweden
- Volunteers
- 17 people
- Sponsor
- Karolinska Institutet
Posttraumatic Stress Disorder
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with at least severe PTSD. The main question it aims to answer is: Do three sessions of MDMA-assisted therapy reduce PTSD…
- Trial name
- NCT03537014
- Testing
- Therapy, midomafetamine HCl
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- Resilient Pharmaceuticals
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
A Comparison of CPT Versus ART Versus WL
The purpose of this research study is to compare the effectiveness of two treatments for the symptoms of Posttraumatic Stress Disorder (PTSD) with a no therapy, wait-list control condition.
- Trial name
- NCT03384706
- Testing
- Cognitive Processing Therapy (CPT), Accelerated Resolution Therapy (ART)
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Stress Disorders, Post-Traumatic, Combat Disorders
Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to determine whether prazosin will: reduce the incidence of nightmares and sleep disturbance increase functioning and sense of well being in combat-trauma exposed Operation Iraqi Freedom/Operation…
- Conditions
- Stress Disorders, Post-Traumatic, Combat Disorders, Sleep Disorders
- Trial name
- NCT00990106
- Testing
- prazosin hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Stress Disorders, Post Traumatic
Exposure Therapy for Active Duty Soldiers With Post Traumatic Stress Disorder
This study is evaluating the efficacy of virtual realty exposure therapy (VRET)by comparing it to prolonged exposure therapy (PE) and a waitlist (WL) group for the treatment of post traumatic stress disorder (PTSD) in active duty…
- Trial name
- VRPE (NCT01193725)
- Testing
- Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- National Center for Telehealth and Technology
PTSD, Depression
Effectiveness of Combined Intervention Approaches in the Treatment of Affective Disorders and Chronic Pain in War Victims
This study will measure the effects of biofeedback supported cognitive behavioral therapy (BF-CBT) and group physiotherapy intervention in victims of torture and massive violence in Kosovo.
- Conditions
- PTSD, Depression, Anxiety, Chronic Pain
- Trial name
- NCT01696578
- Testing
- BF-CBT and group physiotherapy
- Where
- Kosovo
- Volunteers
- 31 people
- Sponsor
- Rehabilitation and Research Centre for Torture Victims