Clinical trials: Stress Disorder, Post-Traumatic
Sexual Violence, Posttraumatic Stress Disorder (PTSD)
Testing STAR and TextSTAR: A Randomized Controlled Trial
The goal of this clinical trial is to learn whether a video given for recent sexual assault survivors and/or a 3-week text messaging intervention with similar content is effective at reducing mental health problems and substance…
- Conditions
- Sexual Violence, Posttraumatic Stress Disorder (PTSD), Opioid Misuse
- Trial name
- NCT07630428
- Testing
- Skills Training in Active Recovery (STAR) Video, Text Skills Training in Active Recovery (TextSTAR) program
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- University of Wisconsin, Madison
Post Traumatic Stress Disorder
Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to understand nitrous oxide effects in post traumatic stress disorder (PTSD)
- Trial name
- tN2O (NCT03375294)
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Feedback, Psychological, Stress Disorders, Post-Traumatic
Neurofeedback Prevention For Early Stress Related Adversity
Exposure to life threatening, traumatic and stress inducing events in general is an inevitable part of military combat service .
- Trial name
- NFPES (NCT02477722)
- Testing
- EFP-NF
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
PTSD
Building Experience for Treating Trauma and Enhancing Resilience (BETTER)
Posttraumatic stress disorder (PTSD) is a significant problem among underserved populations who receive care in community health centers.
- Trial name
- BETTER (NCT05330442)
- Testing
- Written Exposure Therapy (WET)
- Where
- 10 sites in United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- RAND
Treatment Resistant Disorders, Post Traumatic Stress Disorder
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a complex disorder expressed as a variety of neurobiological symptoms, including anxiety, re-experiencing, hyperarousal, and avoidance symptoms, along with comorbidities such as anxiety…
- Trial name
- NCT05243329
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Halucenex Life Sciences Inc.
Posttraumatic Stress Disorder
Modafinil in the Treatment of PTSD (Posttraumatic Stress Disorder)
The purpose of this study is to determine if modafinil is more effective than placebo in the treatment of posttraumatic stress disorder (PTSD) in male combat veterans who have been deployed to Iraq or Afghanistan.
- Trial name
- NCT01726088
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Biomedical Research Foundation
Sickle Cell Disease, Pain
Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease
Children with sickle cell disease may experience frequent painful episodes. This, together with the traumatic experiences during a hospitalization, can lead to the development of posttraumatic stress reactions.
- Conditions
- Sickle Cell Disease, Pain, Pain, Chronic Disease
- Trial name
- RELAX (NCT07001631)
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Adult ALL, Post-traumatic Stress Disorder
Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms
The Eye Movement Desensitization and Reprocessing Protocol (EMDR) was first developed by Francine Shapiro in 1987 and can be adapted for online and in presence administration.
- Conditions
- Adult ALL, Post-traumatic Stress Disorder, Obsessive-Compulsive Disorder, Disgust
- Trial name
- MDL (NCT06110702)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Stress
Comparative Effectiveness of Stress Management
Many formerly homeless adults with chronic mental illness experience treatment resistant symptoms for which pharmaceutical agents and cognitive behavioral therapy are not effective.
- Trial name
- NCT03203902
- Testing
- Psychoeducation and Therapeutic Touch
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
Insomnia, Posttraumatic Stress Disorder
Blood Pressure, Heart Rate Variability & Sleep in Veterans With PTSD
Sleep disturbance and posttraumatic stress disorder (PTSD) are common conditions in returning Veterans, and both conditions are known to increase the risk of cardiovascular disease.
- Conditions
- Insomnia, Posttraumatic Stress Disorder, Hypertension, Cardiovascular Disease
- Trial name
- NCT01920451
- Testing
- Cognitive-Behavioral Therapy for Insomnia (CBTI)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Durham VA Medical Center
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
Opioid-Related Disorders, Substance-Related Disorders
Pre-Pilot (R61) WINGS+++: mHealth to Improve MOUD Uptake in Women Experiencing Intimate Partner Violence and PTSD
The goal of this pre-pilot for the clinical trial is to develop a mobile health (mHealth) program called WINGS+++ can help women with opioid use disorder or other substance use disorders who have experienced intimate partner…
- Conditions
- Opioid-Related Disorders, Substance-Related Disorders, Intimate Partner Violence (IPV), Stress Disorders, Post-Traumatic
- Trial name
- NCT07665502
- Testing
- Pre-Pilot WINGS++++
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Dawn A. Goddard-Eckrich
Substance-Related Disorders, Depression
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously.
- Conditions
- Substance-Related Disorders, Depression, Stress Disorders, Post-Traumatic, Child Abuse
- Trial name
- NCT04637581
- Testing
- Wraparound
- Where
- 4 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Psychiatric Disorders, Depression - Major Depressive Disorder
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning.
- Conditions
- Psychiatric Disorders, Depression - Major Depressive Disorder, Schizophrenia and Other Psychotic Disorders, Anxiety and Mood Disorders
- Trial name
- NCT07506070
- Testing
- Action-Based Cognitive Remediation
- Volunteers
- 160 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Posttraumatic Stress Disorder
The Role of Expectations in the Development of Intrusive Memories
In the experimental study, the well-established trauma film paradigm will be used to investigate the impact of expectations on the development of intrusive memories as a hallmark symptom of PTSD.
- Trial name
- NCT03950869
- Testing
- Positive Expectation Manipulation, Negative Expectation Manipulation
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Insomnia
Ramelteon for Complex Insomnia in Veterans With PTSD
Obstructive sleep apnea is commonly reported in Veterans with post-traumatic stress disorder, which can potentiate symptoms of anxiety and depression, daytime symptoms and worsen nightmares.
- Trial name
- DORMI (NCT03265951)
- Testing
- Ramelteon, Usual Care
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Posttraumatic Stress Disorder, Major Depressive Disorder
Predicting SSRI Efficacy in Veterans With PTSD
This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective…
- Trial name
- SSRI (NCT04183205)
- Testing
- LDAEP, sertraline
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder
Early EMDR Following Covid-19 Critical Illness: A Feasibility Trial
Primary objective is to evaluate the feasibility of delivering an online early Eye Movement Desensitisation Reprocessing (EMDR) Recent Traumatic Events Protocol (R-TEP) to patients who have survived Covid-19 related critical…
- Conditions
- Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder, Anxiety Disorders, Depression
- Trial name
- Cov-EMERALD (NCT04455360)
- Testing
- Eye Movement Desensitisation and Reprocessing Recent traumatic Event Protocol
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Post Traumatic Stress Disorder
Online Mental Health Program for Female College Students
Late adolescence and early adulthood are the most exposed to trauma. College students exposed to trauma may experience depression, anxiety, stress, and difficulties adapting to college life.
- Trial name
- NCT04982523
- Testing
- Online Mental Health Program
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- CHA University
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