Clinical trials: Stress Disorder, Post-Traumatic
PTSD, Cardiac Arrest
Acceptance and Mindfulness Based Exposure Therapy for Survivors of Cardiac Arrest
The primary goal of this uncontrolled pilot trial is to examine feasibility, acceptability, safety, and preliminary efficacy of a new behavioral treatment for survivors of sudden cardiac arrest with clinically elevated symptoms…
- Trial name
- AMBET (NCT04596891)
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Post-Traumatic Stress Disorder in Children
Validation of the Turkish Version of PTSD-RI-5
The aim of this study is to investigate the adaptation and validity of the DSM-5 PTSD-RI -5 scale in patients who have been exposed to traumatic events.
- Trial name
- NCT06077474
- Testing
- Testing the the DSM-5 UCLA Posttraumatic Stress Disorder Reaction Index Self-Report Scale for Children and Adolescents (PTSD-RI-5)
- Where
- Turkey (Türkiye)
- Volunteers
- 157 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Posttraumatic Stress Disorder
Efficacy Mechanism of N-acetylcysteine in Patients With Posttraumatic Stress Disorder
It has been suggested that N-acetylcysteine exerts neuroprotective effects by regulating neurotransmitters and cell signaling pathways.
- Trial name
- NCT01664260
- Testing
- N-acetylcysteine
- Where
- South Korea
- Sponsor
- Ewha Womans University
Acute Respiratory Failure, Shock
Psychological Trauma and Resilience After Critical Illness
Critically ill patients experience a severe physical disease, associated with a psychotrauma, which may lead to post-traumatic stress disorder (17 to 30% of patients after critical illness) and persistent symptoms of anxiety and…
- Trial name
- RESIREA (NCT05193123)
- Where
- 23 sites in France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
Breast Cancer
Cognition in Breast Cancer Patients: The Impact of Cancer-related Stress
The study will investigate the impact of cancer-related stress and its consequences (acute and posttraumatic stress symptoms, altered cortisol secretion) on cognitive function in breast cancer patients.
- Trial name
- Cognicares (NCT01264562)
- Where
- 6 sites in Germany
- Volunteers
- 254 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders
Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Police officers, correctional service officers, and 911-operators are at increased risk for suffering from trauma-related disorders due to their direct and indirect exposure to life-threatening events, such as shootings, violent…
- Conditions
- Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders, Adjustment Disorders, Acute Stress Disorder
- Trial name
- NCT03152175
- Testing
- Propranolol Hydrochloride
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Douglas Mental Health University Institute
Family Relations, Psychological Trauma
Multifamily Healing Spaces for Family Resilience in Rwanda
This cluster-randomized waitlist-control trial evaluated Multifamily Healing Spaces (MFHS), a culturally adapted behavioral family intervention for genocide-affected communities in Rwanda.
- Conditions
- Family Relations, Psychological Trauma, Stress Disorders, Post-Traumatic, Parent-Child Relation
- Trial name
- MFHS-CRT (NCT07621705)
- Testing
- Multifamily Healing Spaces
- Where
- 5 sites in Rwanda
- Volunteers
- 319 people
- Sponsor
- Alexandros Lordos, PhD
Posttraumatic Stress Disorder
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of…
- Trial name
- VA CORT (NCT01090180)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Integrated Treatment for Opioid Use Disorder and PTSD
This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone…
- Trial name
- NCT06641115
- Testing
- HOPE Therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Stress Disorders, Posttraumatic
Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury
This study will evaluate the impact of a brief psychosocial intervention delivered to children or adolescents who are hospitalized for an unintentional injury.
- Trial name
- NCT00451282
- Testing
- stepped preventive care
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Children's Hospital of Philadelphia
Post-traumatic Stress Disorder, Persian Gulf Syndrome
Sentra AM® and Sentra PM® for Post-traumatic Stress Disorder (PTSD) and Gulf War Fibromyalgia (GWF)
An open-label clinical outcomes study to determine the safety and efficacy of Sentra AM® and Sentra PM® for post-traumatic stress disorder (PTSD) and Gulf War fibromyalgia (GWF).
- Trial name
- GWF001 (NCT01437891)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stephanie Pavlik
Posttraumatic Stress Disorder, Moral Injury
Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury
Given the prevalence of posttraumatic stress disorder (PTSD) and moral injury in combat Veterans and the limitations to current treatments, novel approaches are needed to target both PTSD and moral injury and directly impact…
- Trial name
- NCT03906240
- Testing
- Moral Elevation intervention
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Fluoxetine vs EMDR to Treat Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to compare two treatments for post-traumatic stress disorder (PTSD): fluoxetine (an antidepressant) and Eye Movement Desensitization and Reprocessing (EMDR, a psychological treatment in which the…
- Trial name
- NCT00000379
- Testing
- Fluoxetine, EMDR
- Where
- United States
- Sponsor
- Boston University
Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Eye Movement Intervention With Different Memory Reactivation Procedures for Intrusive Traumatic Memories
Post-Traumatic Stress Disorder (PTSD) and trauma-related symptoms are often characterized by recurrent intrusive memories that cause distress and interfere with daily functioning.
- Trial name
- NCT07767396
- Testing
- Unconscious Trauma Reactivation plus Eye Movements, Active Trauma Memory Reactivation plus Eye Movements, Neutral Memory Reactivation plus Eye Movements
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Shaanxi Normal University
Stress Disorders, Post-Traumatic
Comparison of Couple-Based PTSD Treatment and Couple-Based PTSD Education
The study is designed to evaluate the efficacy of a novel couple-based treatment for PTSD, called Structured Approach Therapy, to decrease PTSD and improve the marital and social functioning of Iraqi war Veterans and their…
- Trial name
- NCT01022203
- Testing
- Structured Approach Therapy, PTSD Family Education
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Depressive Disorder
Whole Health in VA Mental Health: Omnis Salutis
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use disorders.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Disorder, Anxiety Disorders, Substance-Related Disorders
- Trial name
- OS RCT (NCT05400252)
- Testing
- Omnis Salutis, Health and Wellness
- Where
- 2 sites in United States
- Volunteers
- 238 people
- Sponsor
- VA Office of Research and Development
Psychotic Disorders, Psychological Trauma
Prevalence of Traumatic Events and PTSD in Immigrant and Non-immigrant Patients With Psychotic Disorder
Higher rates of psychosis are described in migrant population. Likewise, this populations could suffer several adversities during migration process that could lead to higher exposure to traumatic events and higher rates of…
- Conditions
- Psychotic Disorders, Psychological Trauma, Stress, Psychological, Cross-Cultural Comparison
- Trial name
- NCT04867447
- Testing
- Psychological trauma evaluation
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Parc de Salut Mar
Depression, Major Depressive Disorder
The Treatment of Depression With Yoga and Walking
This randomized controlled trial is designed to test the Vagal-gamma amino-butyric acid (GABA) Hypothesis that one of the mechanisms by which yoga-based practices improve mood and decrease anxiety is by correcting an autonomic…
- Conditions
- Depression, Major Depressive Disorder, PTSD, Anxiety
- Trial name
- NCT02907476
- Testing
- Iyengar Yoga, Walking
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Boston University
Posttraumatic Stress Disorder (PTSD)
High-Intensity Inpatient MDMA-Assisted Psychotherapy for PTSD
This study will evaluate the feasibility, safety and efficacy of high-intensity inpatient MDMA-assisted psychotherapy for treatment-refractory posttraumatic stress disorder.
- Trial name
- HI-MAP (NCT06954025)
- Testing
- High-intensity inpatient MDMA-assisted psychotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- ARQ National Psychotrauma Centre
Grief Disorder, Prolonged
A Multifaceted Intervention Strategy for Relatives of End-of-life Patients in the Emergency Department
In France, a study has reported that about 0.2% of patients visiting the ED died in the ED. A large survey of 145 EDs in 3 French speaking countries has reported that a median of 2 patients dies each week in each ED and its…
- Trial name
- MYRIADE (NCT06733974)
- Testing
- Multi-faceted Intervention
- Where
- France
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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