Clinical trials: Stress Disorder
Anxiety Disorders, Depression
Personalized Feedback for Distress Intolerant Smokers
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and distress tolerance.
- Conditions
- Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence
- Trial name
- NCT03918031
- Testing
- PFI for Smoking & Distress Tolerance, PFI for Smoking Only
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Houston
Posttraumatic Stress Disorder
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with at least moderate PTSD.
- Trial name
- NCT04077437
- Testing
- Therapy, Midomafetamine
- Where
- 14 sites in United States, Israel
- Volunteers
- 121 people
- Sponsor
- Resilient Pharmaceuticals
Urinary Retention, Lower Urinary Tract Symptoms
Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery
This is a placebo controlled randomized controlled trial of perioperative use of tamsulosin to prevent postoperative urinary retention in female pelvic reconstructive surgery.
- Conditions
- Urinary Retention, Lower Urinary Tract Symptoms, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT03524339
- Testing
- Tamsulosin
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
PTSD
Connecting Women to Care: Home-based Psychotherapy for Women With MST Living in Rural Areas
Military sexual trauma (MST) is a common duty-related stressor which occurs among one in four female Veterans and is associated with substantial concerns about social isolation and high rates of PTSD.
- Trial name
- CWC (NCT03429166)
- Testing
- Skills Training in Affective and Interpersonal Regulation, Present Centered Therapy
- Where
- 2 sites in United States
- Volunteers
- 204 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack
This randomized controlled trial evaluates efficacy of combined prolonged exposure (PE) and the selective serotonin reuptake inhibitor (SSRI) paroxetine in the treatment of survivors of the World Trade Center (WTC) attacks.
- Trial name
- NCT01130103
- Testing
- Paroxetine, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Coronary Artery Disease
Safety and Accuracy of Regadenoson-Atropine Stress Echocardiography in CAD
Purpose: The investigators plan to test a newly FDA approved pharmacologic stress agent, Regadenoson, in conjunction with atropine in the use of stress echocardiography for the diagnosis of coronary artery disease.
- Trial name
- REGAT (NCT00894179)
- Testing
- regadenoson and atropine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Henry Ford Health System
Alcohol Abstinence
Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)
Guanfacine may preferentially reduce craving and improve cognitive control in women with Alcohol Use Disorder (AUD), compared to men.
- Trial name
- NCT03137082
- Testing
- Guanfacine XR 3mgs/daily
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University
Stress Disorders, Post-Traumatic Stress Disorder
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure
This study is evaluating the efficacy of virtual reality exposure therapy (VRET) by comparing it to prolonged exposure therapy (PE) and a waitlist(WL) group for the treatment of post traumatic stress disorder (PTSD) in active…
- Trial name
- VRPE Extension (NCT01459705)
- Testing
- Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- National Center for Telehealth and Technology
Mild Traumatic Brain Injury, Distress-based Psychopathology
One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology
Traumatic brain injury (TBI) is the signature wound of Veterans returning from the recent operations in Iraq and Afghanistan (i.e OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Mild Traumatic Brain Injury, Distress-based Psychopathology, Chronic Pain
- Trial name
- NCT02844946
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development
PostTraumatic Stress Disorder
Effects of Delta-9 Tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R61 Study
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT03008005
- Testing
- Dronabinol Cap 5 milligrams (MG), Dronabinol Cap 10 milligrams (MG)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wayne State University
Peripheral Arterial Disease, Intermittent Claudication
A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease
The goal of the proposed pilot study is to evaluate the feasibility of a new leg heat therapy system treatment for patients with lower extremity PAD.
- Trial name
- NCT05335161
- Testing
- Home-based leg heat therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Purdue University
Attendance at Treatment, PTSD, Substance Use, and Attendance at Treatment
Evaluation and Treatment of Substance Abuse in Veterans With PTSD Disability Claims
Veterans can apply for compensation and pension (C \& P) benefits for a disability related to military service. The application exam for these benefits provides an opportunity for Veterans returning from service to access VA…
- Trial name
- SBIRT-PTSD (NCT01597856)
- Testing
- SBIRT
- Where
- 2 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Stress Management for Patients With Multiple Sclerosis
There is a growing body of literature showing that stressful life events can increase the risk of developing exacerbations and new brain lesions among people with multiple sclerosis.
- Trial name
- NCT00147446
- Testing
- Individual Stress Management, Wait List Control
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- Northwestern University
Depression, Postpartum, Anxiety Disorders
Inhaled Oxytocin and HPA Axis Reactivity
Mothers who were enrolled in the Mood, Mother and Infant study will be eligible to participate in the 6-year follow-up maternal visit.
- Conditions
- Depression, Postpartum, Anxiety Disorders, Stress, Psychological
- Trial name
- NCT03593473
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Posttraumatic Stress Disorder
Acupuncture for PTSD
Current treatments for Veterans with PTSD include medications and therapy where the patient talks about traumatic events in order to desensitize to them.
- Trial name
- NCT02869646
- Testing
- Procedure: Acupuncture
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD
The current study will modify an already existing therapy for individuals with substance use disorders to address Post Traumatic Stress Disorder (PTSD) in women enrolled in substance use disorders (SUD) treatment who suffer with…
- Trial name
- NCT02755103
- Testing
- Mindfulness Based Relapse Prevention (MBRP)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Post-Traumatic Stress Disorder, Substance Use Disorders
Effectiveness of Peer-Delivered Trauma-Specific Treatment
Patient-Centered Trauma Treatment, i.e., treatment delivered by peers with lived-experience, has the potential to increase access to trauma treatment in underserved communities.
- Trial name
- NCT02081417
- Testing
- Seeking Safety
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of New Mexico
Mental Disorder, Substance Use Disorders
Supported Employment in Patient Aligned Care Teams
In response to the Rehabilitation Research and Development (RR\&D) Deployment Health Research, this study addresses the delivery of an evidenced-based vocational rehabilitation, specifically Individual Placement and Support…
- Conditions
- Mental Disorder, Substance Use Disorders, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT02400736
- Testing
- Individual Placement and Support (IPS), Treatment as Usual Vocational Rehabilitation/Transitional Work (TUA-VR)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease, Myocardial Perfusion Abnormalities
Regadenoson Real Time Perfusion Imaging Trial-Optison
The purpose if this study is to examine how effective Regadenoson is in detecting coronary artery disease during a stress echocardiogram when Optison is administered.
- Trial name
- NCT01489176
- Testing
- Regadenoson; Optison
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska
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