Clinical trials: Stress Disorders, Posttraumatic
Posttraumatic Stress Disorder (PTSD)
Trauma Suppression Training for Veterans
Intrusive memories of trauma are a core and often persistent symptom of posttraumatic stress disorder (PTSD). This study tested whether veterans with PTSD could take part in a computer-based training program that teaches people…
- Trial name
- TSTV (NCT07891559)
- Testing
- Web-based Think/No-Think retrieval-suppression training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Palo Alto Veterans Institute for Research
Traumatic Injury, PTSD
Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.
- Conditions
- Traumatic Injury, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT06210711
- Testing
- Treatment as Usual, Brief Prolonged Exposure Therapy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor Research Institute
Posttraumatic Stress Disorder, Metabolic Syndrome
Assessing Trauma-related Links Between Affective and Metabolic Systems
KEY INFORMATION: The purpose of this study is to understand how insulin resistance (how your body processes sugar) and PTSD might be related. The goal is to improve the health of Veterans in three ways: 1.
- Conditions
- Posttraumatic Stress Disorder, Metabolic Syndrome, Insulin Resistance
- Trial name
- ATLAS (NCT07862712)
- Testing
- prazosin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder (PTSD)
EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder
Posttraumatic stress disorder, or PTSD, can affect emotional health, sleep, daily functioning, and quality of life. Written Exposure Therapy is a brief trauma-focused psychotherapy in which participants complete structured…
- Trial name
- TREAT (NCT07766798)
- Testing
- Written Exposure Therapy, Neutral Writing Condition
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mclean Hospital
mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Mindful RAVANS Study
This pilot study is testing a new treatment for people who still have frequent headaches months after a mild traumatic brain injury, with about half of the participants coming from military or veteran backgrounds.
- Conditions
- mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Headache
- Trial name
- RAVANS (NCT07872761)
- Testing
- Cala-RAVANS (Model CR-2)
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Posttraumatic Stress Disorder (PTSD), Trauma Exposure
Predictors & Mechanisms of Adolescent PTSD
This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to…
- Trial name
- NCT07537764
- Testing
- Repeated imaginal exposure: Script Driven Imagery (SDI) task
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Symptoms, Heavy Alcoholic Consumption
Self-administered Neurostimulation Intervention for Firefighter Traumatic Stress to Reduce Alcohol Use: Pilot Study
The goal of this clinical trial is to evaluate the feasibility, acceptability, and appropriateness of a transcutaneous auricular neurostimulation (tAN) protocol in firefighters who engage in heavy drinking, have at least a mild…
- Conditions
- Posttraumatic Stress Symptoms, Heavy Alcoholic Consumption, Alcohol Use Disorder (AUD)
- Trial name
- SANI-T (NCT07868055)
- Testing
- Transcutaneous auricular neurostimulation (tAN)
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Chronic Musculoskeletal Pain, Sexual Assault
Post-traumatic Estradiol Administration and Care Evaluation (PEACE)
This pilot randomized, double-blind, placebo-controlled trial evaluates the feasibility, acceptability, and tolerability of administering a single 6 mg oral dose of 17β-estradiol (E2) to individuals assigned female at birth who…
- Conditions
- Chronic Musculoskeletal Pain, Sexual Assault, Posttraumatic Stress Disorder (PTSD)
- Trial name
- PEACE (NCT07868536)
- Testing
- 17β-estradiol
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Posttraumatic Stress Disorder
Dose Optimization of MDMA-Assisted Therapy for PTSD
This open label, within-subjects dose optimization trial will investigate the optimal number of MDMA-Assisted Therapy treatment cycles (i.e., one MDMA session and three integration sessions) in a sample of U.S.
- Trial name
- DosOp (NCT06418178)
- Testing
- Midomafetamine, Psychotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Bronx VA Medical Center
Posttraumatic Stress Disorder
Impact of Cognitive Behavioral Therapy on PTSD-CVD Link
This is a pilot randomized controlled trial to assess the impact of a first-line treatment for posttraumatic stress disorder (PTSD) (Cognitive Processing Therapy; CPT) versus waitlist control on mechanisms of cardiovascular…
- Trial name
- NCT06429293
- Testing
- Cognitive processing therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder, Alcohol Use Disorder
Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes
The purpose of this study is to learn whether a mobile health application (mHealth App) for posttraumatic stress disorder (PTSD) with brief support can help individuals who are in treatment for alcohol problems.
- Trial name
- NCT05564663
- Testing
- PTSD Coach App + Brief Support, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Michigan State University
Posttraumatic Stress Disorder (PTSD), Posttraumatic Stress Symptom
Deep Brain Reorienting for Posttraumatic Stress Disorder
The goal of this clinical trial is to learn if Deep Brain Reorienting (DBR) works to treat posttraumatic stress disorder (PTSD) symptoms in military veterans.
- Trial name
- NCT07840417
- Testing
- Deep Brain Reorienting, Treatment as Usual (TAU)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Anxiety Disorder, Posttraumatic Stress Disorder
Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use
Individual with anxiety and post-traumatic stress disorder often use alcohol in ways that could cause them harm. Treating both mental health concerns and alcohol use at the same time can help reduce difficulties engaging in…
- Conditions
- Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
- Trial name
- NCT04871100
- Testing
- Unified Protocol- Alcohol, Usual care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Traumatic Injury, Posttraumatic Stress Disorder
CHW-Enhanced Trauma Recovery
This pilot study will evaluate the feasibility, acceptability, and preliminary effectiveness of the Trauma Resilience and Recovery Program Plus (TRRP+), a Community Health Worker-enhanced intervention designed to improve…
- Conditions
- Traumatic Injury, Posttraumatic Stress Disorder, Depression, Social Determinants of Health
- Trial name
- TRRP+ (NCT07818161)
- Testing
- CHW support
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medical University of South Carolina
Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC
Fibromyalgia (FM) pain and PTSD are highly prevalent and comorbid with associated increased risk of negative physical and mental health outcomes, including higher risk for opioid use and suicide.
- Trial name
- SWIFT-RELIEVE (NCT07718984)
- Testing
- tAN plus PEPC
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
PTSD - Post Traumatic Stress Disorder, Posttraumatic Stress Disorder (PTSD)
Treatment for PTSD and Tinnitus
In this study, researchers are examining the best sequence of interventions for posttraumatic stress disorder (PTSD) and tinnitus.
- Conditions
- PTSD - Post Traumatic Stress Disorder, Posttraumatic Stress Disorder (PTSD), Tinnitus
- Trial name
- NCT07106593
- Testing
- Cognitive Processing Therapy, CBT-t
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Traumatic Injury, Technology
Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes…
- Conditions
- Traumatic Injury, Technology, Posttraumatic Stress Disorder, Adolescents
- Trial name
- NCT05086757
- Testing
- TRRP, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder (PTSD)
Integrated Health Care for PTSD
The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with…
- Trial name
- NCT07220681
- Testing
- Yoga and meditation, Wellness, Positive affect
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Veterans Medical Research Foundation
Posttraumatic Stress Disorder, Anger
Mobile Anger Reduction Intervention
Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stress disorder (PTSD).
- Trial name
- MARI (NCT06094933)
- Testing
- Mobile Anger Reduction Intervention (MARI), Health Education Condition (HED)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Opioid Use Disorder
tAN for PTSD and OUD in Buprenorphine Therapy
The goal of this research study supported by the HEAL Initiative (https://heal.nih.gov) is to investigate the effects transcutaneous auricular neurostimulation (tAN), as delivered through the Sparrow Ascent device, on helping…
- Trial name
- NCT06130501
- Testing
- Sparrow Ascent tAN
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati