Clinical trials: Stress Disorders, Posttraumatic
Post Traumatic Stress Disorder, Depression
Does an Occupational Therapy Program Enhance Mental Health Outcomes for Veterans Who Scuba Dive
The purpose of the study is to investigate whether an occupational therapy program could enhance mental health outcomes for veterans who SCUBA dive.
- Conditions
- Post Traumatic Stress Disorder, Depression, Anxiety, Stress, Psychological
- Trial name
- NCT03928392
- Testing
- SCUBA with Occupational Therapy (OT), Self-Contained Underwater Breathing Apparatus (SCUBA) without OT
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Loma Linda University
Post-Traumatic Stress Disorder
Comparative Effectiveness Research in Veterans With PTSD
VA Cooperative Study CSP #591 is designed to compare the effectiveness of two types of psychotherapy, Prolonged Exposure (PE) and Cognitive Processing Therapy (CPT), for treating posttraumatic stress disorder (PTSD) in male and…
- Trial name
- CERV-PTSD (NCT01928732)
- Testing
- Cognitive Processing Therapy (CPT), Prolonged Exposure (PE)
- Where
- 18 sites in United States
- Volunteers
- 916 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Image-guided, Robotically Delivered Transcranial Magnetic Stimulation Treatment for Combat-Related Post-Traumatic Stress Disorder
Mounting amounts of evidence suggests that non-invasive stimulation of the dorsolateral prefrontal cortex (DLPFC) using repetitive transcranial magnetic stimulation (rTMS) maybe a safe and effective treatment modality for…
- Trial name
- NCT02853032
- Testing
- Active repetitive transcranial magnetic stimulation, robotic arm
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Post Traumatic Stress Disorder
Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD
The purpose of this study is to quantify the therapeutic efficacy and role of trained service dogs on socio-emotional functioning among military veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT03245814
- Testing
- Service Dog
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Posttraumatic Stress Disorder
IOK Treatment Study
The goals of this project are 1) to evaluate the effectiveness of a CBT treatment module addressing the mental health and functional impact of killing in the war zone, 2) to gather data on Veteran stakeholders' perceptions of…
- Trial name
- NCT01605799
- Testing
- IOK Killing Treatment, Wait list control group
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial
This study will consist of a single session of MDMA-assisted therapy with a full dose of MDMA for people who took part in a study of MDMA-assisted therapy in people with posttraumatic stress disorder (PTSD) whose PTSD symptoms…
- Trial name
- NCT01458327
- Testing
- Midomafetamine, Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Nepicastat for Posttraumatic Stress Disorder (PTSD) in OIF/OEF Veterans
This study proposes a multi-site, randomized, double-blind, placebo-controlled clinical trial of the dopamine-ß-hydroxylase (DBH) inhibitor, nepicastat, for the treatment of posttraumatic stress disorder (PTSD) in outpatients who…
- Trial name
- Nepicastat (NCT00659230)
- Testing
- Nepicastat
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tuscaloosa Research & Education Advancement Corporation
Post Traumatic Stress Disorder, Major Depressive Disorder
Antidepressant Response in Older Adults With Comorbid PTSD and MDD
In the Investigator's ongoing studies of Posttraumatic Stress Disorder (PTSD) in older adults, it has been found that older adults with PTSD frequently meet the criteria for comorbid Major Depressive Disorder (MDD).
- Trial name
- NCT04697693
- Testing
- Escitalopram, Duloxetine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute
Post-traumatic Stress Disorder, Insomnia
Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder
This preliminary, open-label study assesses the feasibility of 34mg at bedtime for 6 weeks in Veterans with Posttraumatic Stress Disorder and insomnia.
- Trial name
- PIP (NCT04188392)
- Testing
- Pimavanserin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury, Posttraumatic Stress Disorder
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
The primary objective of this study is to evaluate the efficacy of Cognitively Augmented Behavioral Activation (CABA), a new hybrid treatment for Veterans diagnosed with comorbid mild Traumatic Brain Injury (mTBI) and…
- Trial name
- CABA (NCT02391402)
- Testing
- Cognitively Augmented Behavioral Activation, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Post Traumatic Stress Disorder
Positive Processes and Transition to Health
The R61 will be an open trial to determine if Positive Processes and Transition to Health (PATH) engages the proposed targets: unproductive processing, avoidance, and reward deficits in a sample of 45 adults who have experienced…
- Trial name
- PATH (NCT04678232)
- Testing
- Positive Processes and Transition to Health (PATH)
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Case Western Reserve University
Posttraumatic Stress Disorder
A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients
This is a multicenter retrospective study to investigate the dosage regimens of sertraline in the treatment of Posttraumatic Stress Disorder (PTSD) under current medical practice and the efficacy and safety of this drug in…
- Trial name
- NCT01607593
- Testing
- sertraline (Zoloft)
- Where
- 4 sites in Japan
- Volunteers
- 123 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Posttraumatic Stress Disorder, Anger
Mobile Intervention for Veterans With PTSD and Anger
Anger is the mostly commonly reported reintegration concern among combat Veterans, especially those with PTSD. Problematic anger is associated with significant functional impairment.
- Trial name
- NCT03733028
- Testing
- Mobile Intervention for Reducing Anger (MIRA), Mindfulness Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Problem Drinking
Tools for Health and Resilience Implemented After Violence Exposure (Project THRIVE)
Sexual assault victimization is a common and particularly harmful form of trauma that is associated with increased risk for high-risk drinking and other conditions of public health concern, such as PTSD.
- Trial name
- NCT03703258
- Testing
- App-based intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder
Evaluating a Novel Working Memory Training Program to Decrease Symptoms of PTSD
The study is designed to evaluate the effect of a novel computer training program on PTSD.
- Trial name
- NCT02139137
- Testing
- Computerized Cognitive Training - active
- Volunteers
- 47 people
- Sponsor
- Rick Gulizia
Stress Disorder, Post Traumatic
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)
The purpose of this study is to investigate a new use for a medication called levodopa (L-DOPA). L-DOPA has been approved for use in Parkinson 's disease, but not for Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT02560389
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Wisconsin, Madison
Post Traumatic Stress Disorder
Iloperidone for Symptoms of Arousal in Post Traumatic Stress Disorder (PTSD)
A Double-Blind Placebo-Controlled Random Order Crossover Pilot Study of Iloperidone for Symptoms of Arousal in PTSD.
- Trial name
- NCT01917318
- Testing
- Iloperidone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Stress Disorders, Post-Traumatic
Safety Aid Reduction Treatment for PTSD Among Veterans
The purpose of this project is to examine the acceptability, feasibility, and utility of a safety aid reduction treatment (START) among Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- START-PTSD (NCT04515784)
- Testing
- Safety Aid Reduction Treatment for PTSD
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
PTSD
Ganaxolone in Posttraumatic Stress Disorder (PTSD)
This Phase 2 proof-of-concept study is a double-blind, randomized, placebo-controlled, 15-week investigation of ganaxolone versus placebo for the treatment of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01339689
- Testing
- Ganaxolone
- Where
- 8 sites in United States
- Volunteers
- 112 people
- Sponsor
- Marinus Pharmaceuticals