Clinical trials: Stress Disorders, Posttraumatic
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder
This study will examine MDMA-assisted psychotherapy in individuals aged 18 years or older diagnosed with PTSD, with PTSD symptoms not improving after trying at least one treatment.
- Trial name
- NCT00353938
- Testing
- 3,4-methylenedioxymethamphetamine (125 mg), 3,4-methyelendioxymethamphetamine (25 mg), Therapy
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Improving Function Through Primary Care Treatment of Posttraumatic Stress Disorder (PTSD)
The proposed project will examine a promising brief therapy for posttraumatic stress Disorder (PTSD) for use in Veterans Health Administration (VHA) Primary Care and its impact on functional outcomes.
- Trial name
- PE-PC (NCT03581981)
- Testing
- Prolonged Exposure for Primary Care (PE-PC), Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Posttraumatic Stress Disorder
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
The primary objective of this study is to evaluate the efficacy of Cognitively Augmented Behavioral Activation (CABA), a new hybrid treatment for Veterans diagnosed with comorbid mild Traumatic Brain Injury (mTBI) and…
- Trial name
- CABA (NCT02391402)
- Testing
- Cognitively Augmented Behavioral Activation, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Posttraumatic Stress Disorder
Comparing Group Therapies for Veterans With Depression and PTSD
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and PTSD. However, CBT is largely underutilized within Veteran Affairs Medical Centers (VAMCs) due to the cost…
- Trial name
- NCT03979040
- Testing
- Group Transdiagnostic Behavior Therapy, Group Disorder-Specific Therapy (G-DSTs)
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Teaching Loved Ones to Help Veterans Optimize Their PTSD Care and Healing
PTSD occurs in as many as 17% of US military Veterans and is associated with a host of negative, long-term consequences to the individual, their families, and society at large.
- Trial name
- NCT04241094
- Testing
- Loved one assisted treatment
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Improving Veteran Adherence to Treatment for PTSD Through Partnering With Families
Evidence-based psychotherapies (EBP) for PTSD, such as Prolonged Exposure (PE), result in clinically significant symptom relief for many.
- Trial name
- NCT03256227
- Testing
- Family Supported Prolonged Exposure, Standard Prolonged Exposure
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- VA Office of Research and Development
PTSD, Posttraumatic Stress Disorder
The Use of a Novel Peer Education Program for Improving PTSD Treatment Engagement Among Veterans
Behavioral health problems among Veterans have raised awareness of the critical need for more reliable, effective, and accessible ways to recognize those in need, direct them to help, and ensure that they receive the best…
- Trial name
- AboutFace (NCT03521999)
- Testing
- AboutFace, Enhanced Usual Care (eUC)
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Moral Injury
Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury
Given the prevalence of posttraumatic stress disorder (PTSD) and moral injury in combat Veterans and the limitations to current treatments, novel approaches are needed to target both PTSD and moral injury and directly impact…
- Trial name
- NCT03906240
- Testing
- Moral Elevation intervention
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Women's Post Traumatic Stress Disorder (PTSD) Research Study
The purpose of this study is to examine the relationship between trauma and startle. The investigators are also looking at the effect of menstrual phase on this relationship.
- Trial name
- NCT01304940
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Narrative Exposure Therapy (NET)
The purpose of this study is to learn more about Narrative Exposure Therapy for Justice Involved Veterans. This pilot study will examine the feasibility of this intervention in a justice-involved veteran population, and will see…
- Trial name
- NET (NCT03777553)
- Testing
- Narrative Exposure Therapy for Justice-Involved Veterans
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Acupuncture for PTSD
Current treatments for Veterans with PTSD include medications and therapy where the patient talks about traumatic events in order to desensitize to them.
- Trial name
- NCT02869646
- Testing
- Procedure: Acupuncture
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Enhancement of PTSD Treatment With Computerized Executive Function Training
This study focuses on helping Iraq and Afghanistan Veterans with posttraumatic stress disorder (PTSD) benefit fully from therapy by first enhancing their thinking abilities.
- Trial name
- NCT03260127
- Testing
- Computerized executive function training plus CPT (CEFT-CPT), Word game training plus CPT (WT-CPT)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
An RCT of a Primary Care-Based PTSD Intervention: Clinician-Supported PTSD Coach
Posttraumatic Stress Disorder (PTSD) is an often severe and frequently disabling condition. It is associated with compromised health, early mortality, and substantial economic costs.
- Trial name
- NCT02685358
- Testing
- Clinician-Supported PTSD Coach, Primary Care Mental Health Integrated Care as Usual
- Where
- 2 sites in United States
- Volunteers
- 234 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder (PTSD)
The Impact of Vocational Rehabilitation on Mentally III Veterans
To study the impact of Individual Placement and Support (IPS) supported employment (SE) compared to treatment-as-usual vocational rehabilitation program (VRP) for veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT00333801
- Testing
- Vocational Rehabilitation Program (VRP), Individual Placement and Support (IPS)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial
This study will consist of a single session of MDMA-assisted therapy with a full dose of MDMA for people who took part in a study of MDMA-assisted therapy in people with posttraumatic stress disorder (PTSD) whose PTSD symptoms…
- Trial name
- NCT01458327
- Testing
- Midomafetamine, Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Resilient Pharmaceuticals
Depression, Anxiety
Mental Health Assessment Project on the Thailand-Burma Border
The aim of the study is to determine the effectiveness of a transdiagnostic psychotherapy intervention - namely, Common Elements Treatment Approach (CETA) - in reducing the severity of mental health symptoms experienced by…
- Conditions
- Depression, Anxiety, Posttraumatic Stress
- Trial name
- MHAP (NCT01459068)
- Testing
- Common Elements Treatment Approach
- Where
- Thailand
- Volunteers
- 347 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Chronic Pain, Traumatic Brain Injury
Neuromodulatory Treatments for Pain Management in TBI
Traumatic brain injury (TBI) and chronic pain are common and serious health problems for military veterans and often co-occur, leading to poor post-deployment adjustment.
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder
- Trial name
- NCT03418129
- Testing
- Mindfulness, Neurofeedback, Relaxation
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Duke University
Posttraumatic Stress Disorder
Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
This pilot study gathered preliminary evidence of the safety and efficacy of four potencies of smoked cannabis to manage chronic, treatment-resistant PTSD among veterans: (1) High THC/ Low CBD (High THC), (2) Low THC/High CBD…
- Trial name
- NCT02759185
- Testing
- High THC cannabis, High CBD cannabis, THC/CBD cannabis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Multidisciplinary Association for Psychedelic Studies