Clinical trials: Stress Fractures
Knee Osteoarthritis (Knee OA)
Comparison of SVF Injection With and Without Microfracture in Moderate Knee Osteoarthritis
This prospective, randomized controlled clinical trial aims to evaluate the clinical and radiological effects of combining stromal vascular fraction (SVF) therapy with arthroscopic microfracture in patients with knee…
- Trial name
- NCT07112885
- Testing
- Arthroscopic Microfracture Combined with Autologous SVF Injection, Arthroscopic Debridement Followed by Autologous SVF Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Articular Cartilage Defects
Extension Study for Participants of MACI00206 Study of MACI® for the Treatment of Symptomatic Articular Cartilage Defects of the Knee
To examine the 5-year efficacy and safety of MACI implant, compared with arthroscopic microfracture, in participants who received study treatment in the SUMMIT study for treatment of symptomatic articular cartilage defects of the…
- Trial name
- Extension (NCT01251588)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 14 sites in Czechia, France and 5 more
- Volunteers
- 128 people
- Sponsor
- Vericel Corporation
Knee Injuries
Follow-Up Study Evaluating The Long Term Safety and Efficacy of BST-CarGel and Microfracture Repair of the Knee
This follow-up study will evaluate the effects of BST-CarGel® application to a microfractured lesion (investigational) and microfracture alone (control) for up to 5 years from treatment in subjects, treated under Protocols…
- Trial name
- NCT01246895
- Testing
- Microfracture with BST-CarGel, Microfracture without BST-CarGel
- Where
- 16 sites in Canada, Spain
- Volunteers
- 67 people
- Sponsor
- Piramal Healthcare Canada Ltd
Acute Stress Reaction
Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects
The purpose of this study is to explore the efficacy of acutely dosed Neurexan using an experimental stress test called the Trier Social Stress Test
- Trial name
- NEUPRO-OL (NCT01703832)
- Testing
- Neurexan®
- Where
- 2 sites in Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Biologische Heilmittel Heel GmbH
Articular Cartilage Defect
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
The objective of this trial is to demonstrate superior efficacy and safety of MACI compared with arthroscopic microfracture in the treatment of patients (aged 18 to 55 years) with symptomatic articular cartilage defects of the…
- Trial name
- SUMMIT (NCT00719576)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 20 sites in Czechia, France and 5 more
- Volunteers
- 144 people
- Sponsor
- Vericel Corporation
Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD)
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively.
- Conditions
- Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)
- Trial name
- NCT00848393
- Testing
- Fentanyl (High Dose), Fentanyl (Low Dose), Fentanyl (Low Dose) + Dexmedetomidine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Nationwide Children's Hospital
Stress Reaction; Acute
Racial Discrimination and Stress Response
The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or…
- Trial name
- NCT05820659
- Testing
- peer rejection task, conversation about peer rejection, and impossible puzzle task
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Metatarsal Stress Fracture, Stress Fracture of Tibia
Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting
The goal of this clinical trial is to compare photobiomodulation therapy (PBMT) in addition to standard of care in the treatment of tibial and metatarsal bone stress injuries in a military training setting.
- Trial name
- PM12 (NCT05843864)
- Testing
- Photobiomodulation Therapy with Standard Physical Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Brooke Army Medical Center
Cartilage Loss, Microfracture
Effects of Unloader Bracing in Clinical Outcome and Cartilage Physiology Following Microfracture of Chondral Defects
The study will examine clinical and radiographic outcomes of microfracture surgery (a common technique to address isolated areas of cartilage loss) in the knee used with or without unloader bracing.
- Trial name
- Mfxbracing (NCT02016300)
- Testing
- Unloader Bracing, Non-Bracing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Prematurity, Stress Reaction
Pilot Study of Nursing Touch and Biobehavioral Stress
Randomized cross-over clinical trial to determine the effect of a nurse-administered comforting touch intervention on the biobehavioral stress responses of preterm infants hospitalized in the neonatal intensive care unit.
- Trial name
- P-NAT-BIO (NCT05030233)
- Testing
- Nurse-Administered Touch Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University
Acute Stress Reaction
Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects
The purpose of this study is to evaluate the efficacy of acutely dosed Neurexan using an experimental stress test called the Trier Social Stress Test
- Trial name
- NEUPRO-DB (NCT01703819)
- Testing
- Neurexan®
- Where
- 2 sites in Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Biologische Heilmittel Heel GmbH
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Acute Stress Reaction
Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands
The purpose of this study is to explore the effect of Neurexan® on the brain response when participants undergo an emotional stressful condition in verum compared to placebo.
- Trial name
- NEURIM (NCT02602275)
- Testing
- Neurexan
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Biologische Heilmittel Heel GmbH
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Stress Reaction
Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia
The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.
- Trial name
- NCT05899686
- Testing
- Tetanic Stimulus
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Prostate Cancer, Vitamin D Deficiency
Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans
Veterans between the ages of 50-75, who are having a prostate biopsy, will be recruited for their permission to collect an extra biopsy core for RNA-sequencing.
- Conditions
- Prostate Cancer, Vitamin D Deficiency, Stress Reaction
- Trial name
- VitD/RNA-seq (NCT04621500)
- Testing
- cholecalciferol, Standard of Care Prostate Biopsy - collection of 13th core for RNA-seq, Standard of Care Prostate Biopsies at baseline and after one year vitamin D3 supplementation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stress Reaction
Effect of Location of Tetanic Stimuli on Photoplethysmogram
The effect of the location of tetanic stimulus on photoplethysmography signals will be studies in patients under general anesthesia.
- Trial name
- NCT03648853
- Testing
- Tetanic Stimulus
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Subchondral Cysts, Subchondral Bone Edema
SCP Hip Outcomes Study
Post-market clinical outcomes study to collect data on the short- and long-term outcomes for subjects who are undergoing or have undergone the Subchondroplasty® (SCP®) Procedure in the hip in a standard clinical setting.
- Conditions
- Subchondral Cysts, Subchondral Bone Edema, Bone Marrow Edema, Insufficiency Fractures
- Trial name
- NCT03494660
- Testing
- Subchondroplasty Procedure with AccuFill
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Zimmer Biomet
Cognition, Stress Reaction
rTMS to Enhance Cognitive Performance and Promote Resilience
The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as…
- Trial name
- NCT04123496
- Testing
- rTMS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Insufficiency Fractures, Stress Fracture
A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Foot/Ankle
Post Market clinical outcomes study to collect data on the short - and long-term outcomes for subjects who are undergoing or who have undergone the Subchondroplasty Procedure in the foot and/or ankle in a standard clinical…
- Conditions
- Insufficiency Fractures, Stress Fracture, Stress Fracture, Ankle, Foot and Toes
- Trial name
- NCT03087396
- Testing
- Treatment of insufficiency fractures
- Where
- 12 sites in United States, Canada
- Volunteers
- 148 people
- Sponsor
- Zimmer Biomet