Clinical trials: Stress Physiology
Lipoprotein Disorder, Arterial Stiffness
The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Myocardial Deformation
1. Introduction Lipoprotein(a), or Lp(a), is a type of lipoprotein that is structurally similar to LDL (low-density lipoprotein) but carries an additional protein called apolipoprotein (a). 2.
- Conditions
- Lipoprotein Disorder, Arterial Stiffness, Endothelial Dysfunction
- Trial name
- Lpa_endo (NCT07324902)
- Where
- 2 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Cardiovascular Reactivity to Stress
Effects of Yoga on Heart Rate and Heart Rate Variability Responses to Stress
Introduction: Yoga has been shown to reduce stress and have benefits for a number of stress-related disorders. However, the effects of an acute bout of yoga practice on cardiac autonomic response to and recovery from stress…
- Trial name
- NCT04897230
- Testing
- Hatha Yoga, Video Watching
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Heat Stress, Heat Strain
Effects of Solar Radiation on Human Function and Cognition
Solar radiation is a physical phenomenon which interacts with any human being throughout its life on earth. This interaction is associated with numerous physiological functions, as well as a broad spectrum of deleterious effects…
- Trial name
- NCT04160741
- Testing
- Radiation and warm environment, Warm environment, Neutral environment with radiation
- Where
- Greece
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Sports Performance, Sports Nutritional Sciences
Effect of Infusion of Yerba Mate on Oxidative Stress, Physiology, and Performance of Trained Cyclists
This project comes forward with investigations regarding the use of yerba mate infusion in sports performance, providing new knowledge about the effects of its consumption on the performance of trained individuals, thus…
- Conditions
- Sports Performance, Sports Nutritional Sciences, Endurance Performance
- Trial name
- NCT04642144
- Testing
- Yerba mate infusion, Carbohydrate meal
- Where
- Brazil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Catarina
Intense Exercise
Bananas as an Energy Source During Exercise: a Metabolomics Approach
This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and…
- Trial name
- NCT01581190
- Testing
- Bananas versus 6% carbohydrate beverage
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Pregnancy, Gestational Diabetes Mellitus (GDM)
Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy
This study is a randomized controlled clinical trial designed to evaluate the effect of a polyphenol-rich dietary intervention during pregnancy on endothelial function, oxidative stress biomarkers, and maternal and neonatal…
- Conditions
- Pregnancy, Gestational Diabetes Mellitus (GDM), Preeclampsia, Hypertension, Pregnancy-Induced
- Trial name
- PREGPOLY (NCT07656532)
- Testing
- Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Gestational Diabetes, Oxidative Stress
Role of NADPH Oxidase in Microvascular Dysfunction Following GDM
The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.
- Conditions
- Gestational Diabetes, Oxidative Stress, Vascular Endothelial Function
- Trial name
- NCT05946798
- Testing
- Acetylcholine, Insulin aspart
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Stress
Natural Modulators of Immune Function and Mood
The objective of this proposal is to recruit 20 healthy subjects per ingredient arm (5 arms x 20 subjects; N= 120 total) to participate in a research study investigating the effects of dietary supplementation for one-month with…
- Trial name
- NCT05508529
- Testing
- Chaga Mushroom, Algae Extract, Black Cumin Seed Oil
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- 3 Waves Wellness
Sleep, Blood Pressure
Sleep and Social Experiences Study 2
This study aims to to test effects of sleep loss on perceived discrimination and cardiovascular functioning as well as identify moderators of the racial discrimination and objective sleep link in a sample of 80 African Americans.
- Trial name
- SASE2 (NCT05166590)
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oxidative Stress
The Acute Effect of Spices on Vascular Health
The investigators aim to conduct a 3-period randomized controlled crossover study to investigate the postprandial effects of a high fat meal with spice on endothelial function, lipids/lipoproteins, immune function and plasma…
- Trial name
- NCT03064958
- Testing
- Herbs and spices, High fat meal
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Diseases
Predictive Medicine Research. (PRE MED)
Principal Investigator: Arshed A. Quyyumi, MD To establish normal values by age, race, and gender of novel markers of risk in healthy subjects necessary to predict precise risk of cardiovascular disease in an individual.
- Trial name
- NCT00336570
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Emory University
Sedentary Lifestyle, Aerobic Exercise
Aerobic Exercise on Platelet Mitochondrial Function
This study explores how exercise affects blood platelets and their role in clotting. Regular exercise can influence how efficiently clots form in the body.
- Trial name
- NCT06897995
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy, Diet Modification
Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.
50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels. Hypothesis Relative induced-hyperuricemia by the vegan diet is not associated with impaired endothelial function if vitamin B12 and folic acid levels…
- Trial name
- NCT03849677
- Testing
- Endothelial function and inflammation
- Where
- Belgium
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Healthy Young Women, Regular Exercise
Exercise, IMA and Sulfhydryl Biomarkers in Young Women
Background: Regular physical activity exerts systemic health benefits that extend to redox homeostasis and antioxidant defense mechanisms.
- Conditions
- Healthy Young Women, Regular Exercise, Oxidative Stress, Redox Homeostasis
- Trial name
- IMA-SH & Exerc (NCT07181044)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duvenciler Anadolu Lİsesi
Intergenerational Trauma
Child Cognitive-Affective Resilience Following 13-11 Event : A Pluridisciplinary Study of Intergenerational Transmission of a Traumatic Event
CARE 13-11 study explores the transmission of trauma within families. Exposure to a traumatic event can have an impact on those directly exposed, but also on their family.
- Trial name
- CARE 13-11 (NCT07203443)
- Testing
- MRI, Psychological assessment, Cognitive assessment
- Where
- France
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mountain Sickness
Three New Ideas to Protect Special Forces From the Stress of High Altitude
Acute Mountain Sickness (AMS) is a well-documented syndrome that affects 42% of non-acclimatized individuals traveling to altitudes above 10,000 feet.
- Trial name
- NCT02463357
- Testing
- Quercetin, Nifedipine extended release, Methazolamide
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy, Hypercholesterolemia
Health Effects of Consuming Olive Pomace Oil
Healthy and at risk (hypercholesterolemic) subjects consumed during 4 weeks 45 g/d of either olive pomace oil (OPO) or high oleic acid sunflower oil (HOSO) as the only dietary fat in a randomized, crossover trial.
- Trial name
- ORUJOSALUD-1 (NCT04997122)
- Testing
- Olive pomace oil, High oleic acid sunflower oil
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Aging Well, Walking, Difficulty
Heat Therapy, Functional Capacity, and Vascular Health in Older Adults
To test the hypothesis that home-based leg heat therapy improves functional capacity, vascular function, and exercise hyperemia in older adults.
- Conditions
- Aging Well, Walking, Difficulty, Hyperemia
- Trial name
- NCT05706181
- Testing
- Home-based leg heat therapy
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Musculoskeletal Pain, Cognitive Change
Health, Wellbeing and Performance in Law Enforcement Workers
This study aims to assess current health and fitness of law enforcement workers in various roles, and to evaluate the impact of an exercise intervention on markers on physical and mental wellbeing in this population.
- Conditions
- Musculoskeletal Pain, Cognitive Change, Occupational Stress, Inflammation
- Trial name
- NCT04204486
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London