Clinical trials: Stress Physiology
Opioid Use Disorder
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs.
- Trial name
- NCT04231708
- Testing
- Yohimbine + Hydrocortisone, Active rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
Laser Thermotherapy, Stress Urinary Incontinence
Factors Affecting Therapeutic Efficacy of Vaginal Laser Therapy for Female Stress Urinary Incontinence, and the Effect of Vaginal Laser Therapy on Overactive Bladder Syndrome and Sexual Function
The main aim of this study is to elucidate factors affecting treatment efficacy of vaginal laser therapy.
- Trial name
- NCT03693690
- Testing
- Vaginal laser thermotherapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Far Eastern Memorial Hospital
Metabolic Syndrome
Effects of Nut Consumption on Metabolic Syndrome
This study aimed to investigate the effects of nut consumption on metabolic parameters and biomarkers related to inflammation, oxidative stress, and endothelial function in Korean adults with metabolic syndrome.
- Trial name
- NCT02023749
- Testing
- Nut group
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Food and Drug Safety, Korea
Dyslipidemia, Oxidative Stress
Brazil Nut Consumption in Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities
The purpose this research is to check the effect of Brazil Nuts consumption in oxidative stress, metabolic abnormalities and microvascular endothelial function dyslipidemic and hypertensive patients.
- Trial name
- NCT01990391
- Testing
- Brazil nut flour
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Fabry Disease
Impact of Agalsidase Alfa Therapy on Cardiac funcTION in Patients With Fabry's Cardiomyopathy
Study Design: This is an observational study. No treatment or intervention will be assigned to the subjects. All patients will receive full standard of care concomitant medication for the treatment of their cardiac condition.
- Trial name
- NCT03230591
- Testing
- Echocardiography
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Traumatic Brain Injury, Post-Concussive Symptoms
Long-Term Outcomes Following HBOT
This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT07732374
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Summit Hyperbarics and Wellness
Hyperthermia, Cardiac Functional Disturbances During Surgery
Effect of Heat Stress on Global LV Function in Anesthetized Humans
Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole.
- Trial name
- NCT04553900
- Testing
- Transesophageal Echocardiography
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Diego
High-risk Pregnancy
Leg Heating in Pregnant Women With Obesity
Obesity is a major risk factor for hypertensive disorders of pregnancy (HDP). The underlying mechanisms are largely unclear, but maternal vascular endothelial dysfunction is likely involved.
- Trial name
- NCT06932250
- Testing
- Leg heating
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Psychological Distress, Life Style Induced Illness
Implementation and Evaluation of Primary Care Behavioral Health in Sweden
In this multicenter study, the investigators want to compare treatment outcomes for patients with mental and behavioral health problems in traditional primary care (Care As Usual, CAU) and primary care centres that work according…
- Conditions
- Psychological Distress, Life Style Induced Illness, Life Stress, Mental Health Disorder
- Trial name
- KAIROS (NCT05335382)
- Testing
- Brief Interventions (BI), Care As Usual (CAU)
- Where
- 17 sites in Sweden
- Volunteers
- 666 people
- Sponsor
- Linnaeus University
1- Microvascular Function, 2-oxidative Stress
Acute and Short-term Chronic Effects of Galvus (Vildagliptin) in Diabetes Type 2 Obese Women
The prevalence of obesity and type 2 diabetes mellitus (T2DM) has increased progressively in the past decades, and consequently, a higher incidence of cardiovascular diseases is observed.
- Conditions
- 1- Microvascular Function, 2-oxidative Stress, 3-inflammation
- Trial name
- NCT01827280
- Testing
- Vildagliptin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Rio de Janeiro State University
Inflammatory Response After Surgery, Postoperative Recovery
Double-blind Pilot Study on the Effect of Anionic Exposome Enrichment (Biow) on Recovery and Sleep Quality in Postoperative Patients
Airborne nanoparticle exposure is increasingly recognized as a significant contributor to oxidative stress, mitochondrial dysfunction, and low-grade systemic inflammation-factors that impair postoperative recovery.
- Trial name
- EOX (NCT06968000)
- Testing
- EOX Anion-Enriched Hospital Room
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Aging, Menopause
MitoQ and Exercise Effects on Vascular Health
An impairment in vascular function can lead to the development of age-associated cardiovascular disease (CVD), the leading cause of death in postmenopausal women.
- Trial name
- MITO-STEP (NCT05686967)
- Testing
- MitoQ, Aerobic exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism and Endothelial Function.
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in healthy South Asian and White European women.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03712501
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Stress Urinary Incontinence (SUI), Transobturator Tape
Hybrid Transobturator Tape Versus Conventional Synthetic Tape for Stress Urinary Incontinence
This randomized controlled trial compares the safety, efficacy, and impact on female sexual function of a novel hybrid transobturator tape (combining an autologous rectus fascia strip with a polypropylene mesh) versus standard…
- Conditions
- Stress Urinary Incontinence (SUI), Transobturator Tape, Hybrid Sling, Female Sexual Function
- Trial name
- NCT07762300
- Testing
- Standard Synthetic Transobturator Tape (TOT), Hybrid Transobturator Tape Sling
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Benha University
Exercise Intolerance, Aging
Heat Therapy and Muscle Function Study
Exercise tolerance decreases with age and a sedentary lifestyle. Muscle critical power (CP), is a sensitive measure of exercise tolerance that is more even more relevant to and predictive of endurance performance than VO2max.
- Conditions
- Exercise Intolerance, Aging, Heat Therapy, High Intensity Interval Training
- Trial name
- NCT04733287
- Testing
- High Intensity Interval Training of the Knee Extensors, Muscle Heat Therapy, Muscle Disuse
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Aging, Stress
Improving Everyday Functioning in Adults Aged 70 and Over Using a Multivitamin Supplement
Investigation of the chronic effect of 12 week multivitamin supplementation on markers of everyday function in adults aged 70 and over.
- Trial name
- NCT04112732
- Testing
- Multivitamin
- Where
- United Kingdom
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Stress Urinary Incontinence
Non-ablative Er:Yttrium Aluminum Garnet Laser for Stress Urinary Incontinence (SUI)
Stress urinary incontinence (SUI) is a common complaint in women after childbirth. The aim of this study was to evaluate the efficacy and safety of non-ablative Er:YAG laser therapy in the treatment of SUI and improvement of…
- Trial name
- NCT03296241
- Testing
- laser
- Volunteers
- 114 people
- Sponsor
- Dr Adolf Lukanovič
Oxidative Stress, Inflammation
Influence of a Short Term Supplementation With Ubiquinol on Diverse Aspects Related to the Physical Activity
The General Aim of this study is to verify if a short term supplementation can modulate diverse aspects related to the physical regular high intensity activity.
- Conditions
- Oxidative Stress, Inflammation, Muscle Injury
- Trial name
- NCT01940627
- Testing
- Ubiquinol, Control
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Lipedema, Overweight and Obesity
Ketogenic Diet in Women With Lipedema
Lipedema is a chronic fat tissue disorder that usually affects the lower limbs, excluding the feet. Clinical symptoms of lipedema include a noticeable disproportion between the upper and lower body, a tendency to easy bruising…
- Trial name
- NCT07530341
- Testing
- Low carbohydrate high fat (ketogenic) diet with anti-inflammatory properties
- Where
- Poland
- Volunteers
- 121 people
- Sponsor
- Wroclaw Medical University