Clinical trials: Stress Response
Irritable Bowel Syndrome
Small and Large Bowel Transit Tests Using MRI (Study 1)
Irritable bowel syndrome, (IBS) is a common functional disorder of the gut that can be quite disabling to patients. The most common symptoms of IBS are abdominal pain or discomfort along with erratic changes in bowel habit of…
- Trial name
- NCT01534507
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Post-traumatic Stress Disorder
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can…
- Trial name
- NCT00700999
- Testing
- Paroxetine
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Fear Conditioning
Influence of Escitalopram on Fear Conditioning
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking an antidepressant medication. This medication is called Lexapro (Escitalopram).
- Trial name
- NCT01398514
- Testing
- Escitalopram
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Thermoregulation
Physiological Responses to Heat Stress During High-risk Events
Exertional heat stroke (EHS) affects ~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported.
- Trial name
- NCT06907225
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Stress Reaction, Opioid Use
Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.
Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human…
- Trial name
- NCT03248076
- Testing
- Fentanyl Citrate
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Papanicolaou Hospital
Cesarean Section
Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery
Regional anesthesia has become more popular in cesarean deliveries because most of the parturients prefer being awake during the birth process. In addition, regional anesthesia may be a safer method than general.
- Trial name
- NCT03067896
- Testing
- Bupivacaine, Dexmedetomidine, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hemodynamic Instability
Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia.
- Trial name
- NCT06103721
- Testing
- Dexmedetomidine Injection [Precedex], Normal Saline
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Heat Stress, Aging
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
- Trial name
- NCT06582680
- Testing
- Ambient Heat
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Stress
Intermediate Cervical Plexus Block on Stress Response
The aim of the present study is to investigate the effect of Bilateral Ultrasound-Guided intermediate cervical plexus Block combined with general anesthesia on the stress and inflammatory response in patients undergoing anterior…
- Trial name
- NCT06064214
- Testing
- u/s guided intermediate cervical plexus block
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy
Mitigating Response to Stressors in Pregnant Women
Stress-induced pregnancy complications are significant contributors to preterm labor as well as maternal and perinatal morbidity and mortality.
- Trial name
- NCT06718907
- Testing
- Simulated stimuli, Stress Management
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Normal Subjects
Acute Effects of Artificial Sweeteners or Sugar on Hemodynamic and Metabolic Stress Responses
This exploratory study aims at investigating the acute effects of artificially sweetened and sugar beverage consumption (as compared to water consumption) on acute hemodynamic and metabolic stress response.
- Trial name
- EduStress (NCT02973334)
- Testing
- Ingestion of artificially-sweetened beverages, Ingestion of sugar-sweetened beverages, Ingestion of water
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Healthy
Validation of a Wearable Sensor for Stress Response in a Virtual Reality Environment
Monitor stress response in a virtual reality environment using a wearable sensor to analyze and track heart rate variability (HRV).
- Trial name
- NCT02321774
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Acute Stress Response During Orthodontic Mini-screw Placement
Effects of Music Therapy on Stress During Orthodontic Mini-screw Placement
This randomized clinical trial evaluated acute stress responses during orthodontic mini-screw placement and whether listening to music during the procedure influenced these responses.
- Trial name
- NCT07793669
- Testing
- Music Listening Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Himmet YILDIRIM
Stress
Using Affectionate Communication as a Response to Acute Stress
This study will examine the effects of tending to significant social relationships on managing and reducing stress.
- Trial name
- NCT00468572
- Testing
- Affectionate Writing, Meaningless Writing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Alcohol Consumption, Heat Stress
Ethanol Consumption in the Heat
Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration.
- Conditions
- Alcohol Consumption, Heat Stress, Age
- Trial name
- NCT06935045
- Testing
- Alcohol (Ethanol)
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Pregnancy Related, Stress, Psychological
Maternal Emotions and Diet in Pregnancy
This study seeks to understand how a mother's emotional state in pregnancy influences her biological response to food intake.
- Conditions
- Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy
- Trial name
- PEDIMet (NCT03278392)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Self-compassion, Mindfulness
Effects of the Mindful Self-Compassion (MSC) Program
The efficacy of the Mindfulness Based Stress Reduction (MBSR) program has been widely researched. However, research on the efficacy of a standardized program, specifically focused on self-compassion skills, such as the Mindful…
- Conditions
- Self-compassion, Mindfulness, Mental Health, Well-being
- Trial name
- MSC-Health (NCT05695586)
- Testing
- Mindful Self-Compassion (MSC) training, Mindfulness Based Stress Reduction (MBSR) training
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia de Salamanca