Clinical trials: Stress Ulcer Prophylaxis
Stress Ulcer
Optimizing Stress Ulcer Prophylaxis Practices and Reducing Associated Costs in Intensive Care Units: a Nonrandomized Controlled Study
The study is a prospectively designed, nonrandomized controlled study. It was conducted for six months at the EICU and GICU of a training and research hospital between 1 Jun 2023 and 1 December 2023.
- Trial name
- NCT06586333
- Testing
- stress ulcer prophylaxis
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people
- Sponsor
- Altinbas University
Congenital Heart Disease, Upper Gastrointestinal Bleeding
Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease
Infants with congenital heart disease often require an intervention during their first year of life. Infants are generally admitted to a cardiac intensive care unit and are routinely prescribed stress ulcer prophylaxis to…
- Conditions
- Congenital Heart Disease, Upper Gastrointestinal Bleeding, Stress Ulcer, Infection
- Trial name
- SUPPRESS-CHD (NCT03667703)
- Testing
- Famotidine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Gastrointestinal Disease
Proton Pump Inhibitor (PPI) Inappropriate Use and Economic Burden in Chinese Population
This is a descriptive retrospective database analysis study in using database. All patients with a physician PPI prescription will be selected to estimate the PPI inappropriate use.
- Trial name
- ECHO (NCT03118778)
- Where
- China
- Volunteers
- 90,895 people
- Sponsor
- AstraZeneca
Stress Ulcer Prophylaxis
Economic Outcomes of Enteral and Parenteral Proton Pump Inhibitor (PPI) Use in the Intensive Care Unit (ICU)
This study will be a retrospective electronic medical chart review of all patients admitted to adult intensive care medicine units (ICU) at The Nebraska Medical Center over a three-year period from January 2006 through December…
- Trial name
- NCT00919152
- Where
- United States
- Volunteers
- 534 people
- Sponsor
- University of Nebraska
Stress Ulcer Bleeding
A Multi-center, Double-blinding, Parallel and Positive-controlled Phase III Clinical Trial for Efficacy and Safety Evaluation of Ilaprazole Sodium for Injection on Prevention of Stress Ulcer Bleeding
The purpose of this study is to evaluate the efficacy of the study drug (Ilaprazole Sodium for Injection) for potential effect on preventing stress ulcer bleeding in vulnerable population by comparing the radio of upper…
- Trial name
- NCT05841394
- Testing
- Esomeprazole 40mg, Ilaprazole Sodium
- Where
- 2 sites in China
- Volunteers
- 449 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Respiratory Failure
Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial
The purpose of this study is to determine whether lansoprazole administered nasogastrically is effective for stress ulcer prophylaxis in respiratory intensive care unit.
- Trial name
- NCT00708149
- Testing
- lansoprazole OD
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Far Eastern Memorial Hospital
Ventilator Associated Pneumonia, Etiological Organisms
A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia
Objective of this study was to determine incidence, risk factors, etiological micro-organisms and their antimicrobial susceptibility pattern and outcome of VAP; and to study effect of ranitidine vs.
- Conditions
- Ventilator Associated Pneumonia, Etiological Organisms, Antimicrobial Drug Susceptibility Pattern, Stress Ulcer Prophylaxis
- Trial name
- NCT00702871
- Testing
- Ranitidine, Sucralfate
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Maulana Azad Medical College
Gastrointestinal Bleeding, Stress Ulcers
Stress Ulcer Prophylaxis in the Intensive Care Unit
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported.
- Trial name
- SUP-ICU (NCT02467621)
- Testing
- Pantoprazole, Saline (0.9%)
- Where
- 33 sites in Denmark, Finland and 4 more
- Volunteers
- 3,350 people
- Sponsor
- Dr. Morten Hylander Møller
Stress Ulcer Prophylaxis
Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients
The efficacy of esomeprazole will be compared versus cimetidine (a drug that previously demonstrated prevention of bleeding events) during treatment period in proportion of patients for the prevention of upper GI bleeding.
- Trial name
- SUP (NCT02157376)
- Testing
- Esomeprazole, Cimetidine
- Where
- 15 sites in China
- Volunteers
- 343 people
- Sponsor
- AstraZeneca
Gastrointestinal Hemorrhage, Clostridium Difficile Colitis
Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.
study is to determine if proton pump inhibitors plus enteral nutrition is superior to enteral nutrition alone as a stress ulcer prophylaxis strategy in critically ill patients in terms of incidence of overt and significant GI…
- Trial name
- NCT01477320
- Testing
- Pantoprazole 40 mg IV daily and tube feed.
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Mohamed Saad
Critically Ill Patients, Indication for Stress Ulcer Prophylaxis
Gastric pH in Critically Ill Patients
H2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. Various studies demonstrated superiority of proton pump inhibitors over H2-receptor antagonists in increasing gastric pH and…
- Trial name
- NCT00590928
- Testing
- esomeprazole, ranitidine
- Where
- Austria
- Volunteers
- 75 people
- Sponsor
- Medical University of Vienna
Ulcer
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit
Although stress ulcer is a complication that can cause mortality and morbidity in critical patients, there is still lack of consensus about its prophylaxis. There is also few data available from Taiwan.
- Trial name
- NCT00633035
- Testing
- esomeprazole 40 mg, famotidine 20 mg
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Enteral Nutrition, Gastro Intestinal Bleeding
Effects of Enteral Nutrition on Stress Ulcer Hemorrage. Multicenter Randomized Controlled Trial
Enteral nutrition can provides prophylaxis against stress ulcer bleeding in critically ill patients and there may be no need to use acid suppressing drugs for stress ulcer bleeding prophylaxis in these patients.
- Conditions
- Enteral Nutrition, Gastro Intestinal Bleeding, Stress Ulcer Prophylaxis, Proton Pump Inhibitor
- Trial name
- NCT03098537
- Testing
- enteral nutrition + proton pump inhibitor, enteral nutrition only
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- TC Erciyes University
Stress Ulcer
Pharmacist-Driven Stress Ulcer Prophylaxis Minimization in the Intensive Care Unit
Pharmacologic stress ulcer prophylaxis is routinely used in the intensive care unit (ICU) to prevent upper gastrointestinal (GI) bleeding in critically ill patients.
- Trial name
- NCT06225167
- Testing
- To evaluate the effectiveness and safety of a pharmacist-driven protocol to discontinue stress ulcer prophylaxis in ICU patients when it is no longer indicated according to pre-defined criteria.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Methodist Health System
Stress Ulcer Prophylaxis
Stress Ulcer Prophylaxis Practices in the Intensive Care Unit
The present study aimed to examine the adherence of proton pump inhibitors (PPIs), commonly recommended for stress ulcer prevention (SUP) in patients in the intensive care unit (ICU), according to an international guideline.
- Trial name
- guideline (NCT06620263)
- Testing
- Pre-education period (PreEd), Post-education period (PostEd)
- Where
- Turkey (Türkiye)
- Volunteers
- 495 people
- Sponsor
- Yunus Emre AYHAN
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stress Ulcer Prophylaxis
Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding Prophylaxis In ICU
The purpose of the this Pilot Trial is to determine the feasibility of conducting a large randomized controlled trial (RCT), that aims to examine the efficacy and safety of using pantoprazole compared to placebo for stress ulcer…
- Trial name
- REVISE (NCT02290327)
- Testing
- Pantoprazole
- Where
- 10 sites in Australia, Canada and 1 more
- Volunteers
- 91 people
- Sponsor
- McMaster University
Pressure Injury
Mobile Education for Pressure Injury Prevention and Caregiver Support
This study is a randomized controlled trial designed to evaluate the effectiveness of a nurse-led, mobile health (mHealth) education program for informal caregivers of bedridden patients receiving home healthcare services.
- Trial name
- MOBILE-PIP (NCT07565233)
- Testing
- Mobile Life Without Pressure Injury Application
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Gündem Yakan Şahin
Stomach Ulcer
Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis
Although stress ulcer is a complication that can cause significant mortality and morbidity in critical patients with risk factors, there is still lack of consensus about its prophylaxis.
- Trial name
- NCT00839488
- Testing
- pantoprazole 40 mg iv, famotidine 20 mg iv
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Far Eastern Memorial Hospital