Clinical trials: Stress-Related Disorders
Post-traumatic Stress Disorder
Acceptance and Commitment Therapy to Improve Social Support for Veterans With PTSD
Veterans with PTSD often have impaired social relationships and poor social support. The negative outcomes associated with poor social support are of particular concern for Veterans with PTSD, who often perceive the world to be…
- Trial name
- ACT-SS (NCT04567680)
- Testing
- Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD, Present-Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 107 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder, Stress Disorders
Effectiveness of Cognitive Processing Therapy in Pregnant Women With a History of Pregnancy Loss/Complication
The purpose of this study is to examine the effects of experiencing a previous pregnancy loss or complication on current physiological and emotional aspects of a current pregnancy.
- Conditions
- Post-traumatic Stress Disorder, Stress Disorders, Anxiety, Depression
- Trial name
- NCT01277354
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Post-traumatic Stress Disorder
Recovery After Stress Toolkit (ReSeT): Pilot Study
Experiencing an accident and staying in the hospital can be scary and traumatic for children. The goal of this project is to develop an online resource to help children and their parents develop effective coping skills to manage…
- Trial name
- ReSeT (NCT04830839)
- Testing
- Recovery after Stress Toolkit (ReSeT)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
PTSD
Implementing PTSD Treatment in FQHCs for Michigan Medicaid Enrollees
The purpose of this project is to expand access to trauma-focused treatment among Medicaid Enrollees with PTSD, thereby improving the quality of mental health services delivered to this population.
- Trial name
- PE-PC Pilot (NCT03711266)
- Testing
- PE-PC
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Alcohol Use Disorder
Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot)
The purpose of this study is to assess the effect of pioglitazone on stress- and alcohol-related measures in treatment-seeking individuals with alcohol use disorder (AUD) and elevated levels of stress and anxiety.
- Trial name
- NCT03860753
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Post Traumatic Stress Disorder, Depression
Randomized Control Trial on Trauma Focused CBT in Zambia
The purpose of this study is to study the effectiveness of Trauma Focused Cognitive Behavioral Therapy in subset of children who are affected by trauma with significant mental health symptomatology in order to 1) examine the…
- Conditions
- Post Traumatic Stress Disorder, Depression, Risk Behaviors
- Trial name
- NCT01624298
- Testing
- Trauma Focused Cognitive Behavioral Therapy
- Where
- Zambia
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Post Traumatic Stress Disorder
Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer
The purpose of this study is to test the differences between four active treatment conditions for combat-related Post Traumatic Stress Disorder (PTSD): virtual reality exposure therapy (VRE) or prolonged imaginal exposure therapy…
- Trial name
- NCT01352637
- Testing
- DCS (D-Cycloserine ) + Prolonged Imaginal Exposure, DCS (D-Cycloserine ) + Virtual Reality Exposure
- Where
- 5 sites in United States
- Volunteers
- 192 people
- Sponsor
- Weill Medical College of Cornell University
Combat Disorders, Post-traumatic Stress Disorder
Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder
This project represents the first randomized clinical trial of psychotherapy for older veterans with posttraumatic stress disorder (PTSD). It will compare relaxation training (RT) to prolonged exposure therapy (PE).
- Trial name
- NCT00539279
- Testing
- Prolonged Exposure Therapy (PE), Relaxation Training (RT)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder (PTSD)
Two Stepped Care Models for Posttraumatic Stress Disorder (PTSD) Among Cambodian Refugees With PTSD
This project aims to investigate the efficacy of two models to treat Posttraumatic Stress Disorder (PTSD) for Cambodian refugees in primary care.
- Trial name
- NCT01542372
- Testing
- Medication augmentation, CBT
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Massachusetts General Hospital
PTSD
PTSD Coach App Evaluation
PTSD Coach is a mobile application (app) that aims to teach individuals self-management strategies for symptoms of Post-traumatic Stress Disorder (PTSD). PTSD is a major public health concern.
- Trial name
- NCT02445196
- Testing
- PTSD Coach, Smartphone
- Volunteers
- 120 people
- Sponsor
- Craig Barr Taylor
Stress Disorders, Post-Traumatic
Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD
The purpose of the current study is to develop a better understanding of the brain mechanisms involved in psychological treatments for posttraumatic stress disorder (PTSD).
- Trial name
- NCT02500719
- Testing
- Computational Model - Real-time Support Vector Machine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
PTSD
Safety and Efficacy Study of TNX-102 SL in Patients With Military-related PTSD
This is a 12-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose study that will investigate the efficacy and safety of 5.6 mg TNX-102 SL (2 x 2.8 mg tablets)-a sublingual formulation of cyclobenzaprine.
- Trial name
- HONOR (NCT03062540)
- Testing
- TNX-102 SL
- Where
- 44 sites in United States
- Volunteers
- 358 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Posttraumatic Stress Disorder (PTSD)
Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to study new ways to treat post-traumatic stress disorder (PTSD). Current treatments for PTSD do not work for everyone and it can take time to determine whether a person responds to a chosen…
- Trial name
- NCT02397889
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Stress Neuroadaptation in Tobacco Dependence
The objective of the current study is to evaluate the validity of the No Shock, Predictable Shock, Unpredictable Shock (NPU) stressor task for use as a surrogate endpoint to predict short-term clinical outcomes among smokers…
- Trial name
- NCT03262233
- Testing
- nicotine
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Wisconsin, Madison
PTSD, TBI
Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries
Treatment for veterans who have had a traumatic brain injury (TBI) and who are suffering from post traumatic stress syndrome (PTSD) is varied with varied outcomes.
- Trial name
- PTSD-TBI (NCT02003352)
- Testing
- Functional Neurological Rehabilitation
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Carrick Institute for Graduate Studies
Post-traumatic Stress Disorder
A mGlu2/3 Agonist in the Treatment of PTSD
In this study, we propose to employ a randomized, double-blind, placebo-controlled, outpatient clinical trial to test the efficacy, safety, and tolerability of a 160 mg and 40 mg challenge of the mGlu2/3 agonist pomaglumetad…
- Trial name
- NCT02234687
- Testing
- Pomaglumetad Methionil 160mg, Pomaglumetad Methionil 40mg
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Post Traumatic Stress Disorder, Suicidal Ideation
Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD)
Patients with PTSD, and frequent nightmares, and mild-moderate suicidal ideation, who are already taking a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI) will be randomized to…
- Conditions
- Post Traumatic Stress Disorder, Suicidal Ideation, Nightmares
- Trial name
- REST-ON PTSD (NCT02199652)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Augusta University
Attendance at Treatment, PTSD, Substance Use, and Attendance at Treatment
Evaluation and Treatment of Substance Abuse in Veterans With PTSD Disability Claims
Veterans can apply for compensation and pension (C \& P) benefits for a disability related to military service. The application exam for these benefits provides an opportunity for Veterans returning from service to access VA…
- Trial name
- SBIRT-PTSD (NCT01597856)
- Testing
- SBIRT
- Where
- 2 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post-Traumatic Stress Disorder
Effectiveness of Three Different Psychotherapies for Chronic Post-Traumatic Stress Disorder
This study will examine whether interpersonal psychotherapy is as effective in treating post-traumatic stress disorder as the established therapies of prolonged exposure and relaxation.
- Trial name
- NCT00739765
- Testing
- Interpersonal Psychotherapy, Prolonged Exposure Therapy, Relaxation Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute