Clinical trials: Stricture; Trachea
Tracheal Stenosis
Biodegradable Stents in the Management of Stenoses of the Large Airways
The objective of this project is to determine whether biodegradable polydioxanone stents are efficient in the treatment of adult patients with tracheobronchial stenoses.
- Trial name
- NCT02620319
- Testing
- SX-ELLA Stent DV Tracheal (DV Stent)
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- Ludek Stehlik
Tracheoesophageal Fistula, Esophageal Atresia
Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
The investigators propose a preliminary study performing exome sequencing on samples from patients and their biologically related family members with tracheal and esophageal birth defects (TED).
- Conditions
- Tracheoesophageal Fistula, Esophageal Atresia, Laryngeal Cleft, Tracheal Stenosis
- Trial name
- TED (NCT03455881)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Laryngeal Stenosis, Subglottic Stenosis
Study of Mitomycin-C Application in Laryngotracheal Stenosis
This is a randomized, prospective, double-blind, placebo-controlled clinical trial of the use of mitomycin-C topical application as an adjunctive treatment in the endoscopic surgical treatment of patients with laryngotracheal…
- Conditions
- Laryngeal Stenosis, Subglottic Stenosis, Tracheal Stenosis
- Trial name
- NCT01523275
- Testing
- Mitomycin -C, Saline application
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Esophageal Diseases
Post Market Clinical Study - Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
The aim of this post-market clinical follow-up study is to evaluate the continued safety and performance of the marketed Evolution® Esophageal Stent System (Partially- and Fully Covered).
- Trial name
- NCT05182255
- Testing
- Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 127 people
- Sponsor
- Cook Research Incorporated
Tracheal Stenosis
Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea
Retrospective chart review of UCDMC patients who have undergone esophageal or tracheal balloon dilation to record data including age, gender, diagnosis pre-and post-procedure eating assessment tool, esophagoscopy findings…
- Trial name
- NCT00583960
- Sponsor
- University of California, Davis
Idiopathic Subglottic Stenosis
Adjuvant Steroid Outcomes in Idiopathic Subglottic Stenosis
This study will examine the ability of steroid injections into the site of stenosis following surgical dilation to delay the need for repeated surgical dilations.
- Trial name
- ASTRO (NCT07228104)
- Testing
- Triamcinolone 0.1%
- Where
- 10 sites in United States
- Volunteers
- 226 people
- Sponsor
- Johns Hopkins University
Barrett Esophagus, Esophageal Dysplasia
trūFreeze® Spray Cryotherapy Patient Registry
To collect efficacy and outcomes data related to the use of trūFreeze® spray cryotherapy for the treatment of unwanted tissue in the pulmonary and gastrointestinal settings.
- Conditions
- Barrett Esophagus, Esophageal Dysplasia, Esophageal Neoplasm, Esophageal Stenosis
- Trial name
- NCT01802203
- Testing
- truFreeze Spray Cryotherapy
- Where
- 16 sites in United States
- Volunteers
- 275 people
- Sponsor
- US Endoscopy Group Inc.
Tracheal Stenosis, Intensive Care Unit
Long-term Outcomes of Post-intubation Tracheal Stenosis; 7-year Follow-up
This retrospective, observational, cohort study evaluates the treatment management, long-term outcomes and survival analyses in patients hospitalized in the Intensive Care Unit with a diagnosis of Post-Intubation Tracheal…
- Trial name
- NCT06121024
- Testing
- Interventional Bronchoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Tracheal Stenosis, Subglottic Stenosis
Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis
Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.
- Trial name
- NCT06917222
- Testing
- Slide tracheoplasty, Tracheal resection anastomosis
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University Hospital
Tracheal Stenosis Following Tracheostomy
Interventional Therapy of Tracheal Stenosis
After respiratory weaning, decannulation is sought. To do this, the tracheal cannula is first unblocked, so that patients no longer breathe in and out through the cannula, but (at least partially) "passing" the cannula by the…
- Trial name
- NCT05924087
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Asklepios Neurological Clinic Bad Salzhausen
Idiopathic Subglottic Stenosis (iSGS)
Treatment Alternatives in iSGS (NoAAC PR-02 Study)
The study is aimed at answering the questions; (1) How well do the most commonly used treatments in iSGS work? and (2) What quality-of-life trade-offs are associated with each approach? With the results of this trial, the…
- Trial name
- NoAAC PR-02 (NCT02481817)
- Testing
- Endoscopic dilation of subglottic stenosis, Endoscopic resection of the stenosis, Tracheal Resection
- Where
- 42 sites in United States, Australia and 2 more
- Volunteers
- 1,239 people
- Sponsor
- Vanderbilt University Medical Center
Tracheal Stenosis
Challenges and Management of Post-intubation Tracheal Stenosis
Management of a "difficult airway" remains one of the most relevant and challenging tasks for anesthesiologists and pulmonary physicians.
- Trial name
- NCT06061380
- Testing
- no intervation taken
- Where
- Ethiopia
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Wollo University
Tracheal Stenosis
Role of Bronchoscopy in Assessment of Patients With Post-intubation Tracheal Stenosis
1. To estimate the importance of bronchoscopic treatment of tracheal stenosis and its effectiveness and safety. 2. To diagnose and evaluate tracheal stenosis characteristics as location, vertical extension and severity of…
- Trial name
- NCT04625400
- Testing
- bronchoscope
- Volunteers
- 87 people
- Sponsor
- Assiut University
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices
We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Lung Cancer, Tuberculosis; Tracheitis
- Trial name
- NCT04850742
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus
Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair
Azygos vein preservation revisited: impact on early outcomes after repair of Esophageal atresia/ Tracheo-Esophageal Fistula in newborns. A randomized controlled study.
- Conditions
- Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus, Leak, Anastomotic, Stricture Esophagus
- Trial name
- EArAzygousvp (NCT05957562)
- Testing
- EA/TOF primary repair with Azygos vein preservation, EA/TOF primary repair with Azygos vein sacrifice (disconnection)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Laryngotracheal Lesions, Tracheostomy Complications
Laryngotracheal Lesions in Adults With Long-Term Tracheostomy
This multicenter prospective observational cohort study will enroll 224 adults with a tracheostomy tube in place for at least 14 days.
- Conditions
- Laryngotracheal Lesions, Tracheostomy Complications, Tracheal Stenosis, Tracheomalacia
- Trial name
- NCT07901946
- Testing
- Standardized Three-Station Bronchoscopy
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Hongying Jiang, MD
Chronic Obstructive Pulmonary Disease
Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing
This study is aimed to determine factors leading to obstructive granulation tissue formation after placement of Self-Expandable Metallic Stent (SEMS) in patients with benign tracheal diseases.
- Trial name
- NCT01006200
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
Tracheal Stenosis
DilAtation Versus Endoscopic Laser Resection in Simple Benign trAcheal sTEnosis
Multicenter randomized controlled trial comparing endoscopic laser resection vs dilatation in benign tracheal stenosis.
- Trial name
- AERATE (NCT04719845)
- Testing
- Endoscopic laser resection, Dilatation
- Where
- 4 sites in Canada, France
- Volunteers
- 108 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Stenosis of Trachea
Spray Cryotherapy for the Management of Benign Central Airway Stenosis (Cryo-BAS)
The goal of this clinical trial is to compare spray cryotherapy plus balloon dilatation versus current standard of Care (SoC - steroid injection, radial cuts and balloon dilatation) in patients with benign airway stenosis with…
- Trial name
- Cryo-BAS (NCT06761170)
- Testing
- Spray cryo therapy, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheal Stenosis
Airway Management During Unusual Tracheal Stenosis
Tracheal stenosis is a serious complication following prolonged intubation. There are important differences in the challenges of airway management.
- Trial name
- NCT05317923
- Testing
- Flow Controlled Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul University