Clinical trials: Stricture; Trachea
Tracheal Stenosis, Airway Disease
Endotracheal Dilator to Improve Oxygenation
The purpose of the study is to prospectively assess the use of a modified tracheal balloon dilator in children (<13 years old) with subglottic or tracheal stenosis.
- Conditions
- Tracheal Stenosis, Airway Disease, Pediatric Respiratory Diseases
- Trial name
- EDITION2 (NCT03411928)
- Testing
- Tracheolator
- Where
- South Africa
- Volunteers
- 12 people
- Sponsor
- University of Cape Town
Tracheal Stenosis
Observational Study for the Evaluation of Tracheal Stenosis in COVID-19 Patients
Define the actual incidence of tracheal stenosis in patients who underwent either prolonged intubation or tracheostomy and to compare incidence, clinical course and outcome between COVID-19 and non-COVID-19 patients.
- Trial name
- TS1 (NCT04686721)
- Testing
- Chest CT scan + baseline spirometry
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Idiopathic Subglottic Tracheal Stenosis
Everolimus Trial in Laryngotracheal Stenosis
Subglottic stenosis (obstructing scar in the larynx and trachea) occurs in patients spontaneously (idiopathic), with autoimmune disease, and after long-term breathing tube placement and can result in communication disability and…
- Trial name
- NCT05153668
- Testing
- Everolimus Oral Tablet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Idiopathic Subglottic Stenosis
Effects of Interleukin (IL)-17A Inhibition on Idiopathic Subglottic Stenosis
The purpose of this phase 2 study is to examine if inhibiting IL-17A activation using the biologic drug Taltz, in idiopathic subglottic stenosis patients will decrease scar fibroblast proliferation therefore reducing or…
- Trial name
- NCT05309616
- Testing
- Taltz
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Tracheal Stenosis, COVID-19
Relationship Between Post-Intubation Tracheal Stenosis and Covid-19
Tracheal stenosis (TS) is a serious complication that occurs in approximately 6-22% of patients due to prolonged endotracheal intubation.
- Conditions
- Tracheal Stenosis, COVID-19, Post-Intubation Subglottic Stenosis, Intensive Care Unit
- Trial name
- NCT05682651
- Testing
- tracheal stenosis follow-up file
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Ankara City Hospital Bilkent
Tracheal Stenosis, Subglottic Stenosis
RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis
Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring.
- Trial name
- NCT07258784
- Testing
- Biopsy or surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children
Feasibility and safety of repairing tracheal and bronchial defects in infants and children using cryopreserved donor aortic patches.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Tuberculosis; Tracheitis, Airway Disease
- Trial name
- NCT07240259
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Foreign Bodies, Tumor
High-flow Nasal Oxygen During Rigid Bronchoscopy Under General Anesthesia: a Randomized Controlled Trial
The aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on apnea in patients undergoing general anesthesia with rigid bronchoscopy compared with standard anesthesia methods.
- Conditions
- Foreign Bodies, Tumor, Stenosis Trachea, Bronchus Tumour
- Trial name
- NCT03892408
- Testing
- Optiflow ™
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Adult Subjects With Symptomatic Benign Airway Obstruction, Adult Benign Central Airway Stenosis
Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Central Airway Stenosis
The OXYGEN-RCT trial is a randomized, controlled, double blinded, prospective, multi-center trial to demonstrate the safety and efficacy in adult benign central airway stenosis.
- Conditions
- Adult Subjects With Symptomatic Benign Airway Obstruction, Adult Benign Central Airway Stenosis, Adult Tracheobronchial Stenosis, Tracheal Stenosis
- Trial name
- OXYGEN-RCT (NCT07191860)
- Testing
- The Airiver Pulmonary drug-coated balloon (DCB) dilation, Commercial airway balloon dilation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Airiver Medical, Inc.
Foreign Bodies, Tumor
The Effects of High-flow Nasal Oxygen on Oxygenation During Rigid Bronchoscopy Under General Anesthesia in Pediatric Patients
The aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on maintenance of oxygenation and removal of carbon dioxide during apnoeic period in pediatric patients undergoing general…
- Conditions
- Foreign Bodies, Tumor, Stenosis of Trachea, Bronchus
- Trial name
- NCT03905733
- Testing
- Optiflow
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Tracheal Stenosis
Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures
The purpose of the study is to prospectively assess the use of a modified tracheal balloon dilator that allows gas flow (oxygenation and ventilation) through the device while inflated during dilatation.
- Trial name
- NCT02796326
- Testing
- improved tracheal balloon dilatation
- Where
- South Africa
- Volunteers
- 20 people
- Sponsor
- University of Cape Town
Anomalies of Pulmonary Artery, Congenital
Relationship Between Tracheal and Left Pulmonary Artery Stenosis Index and Prognosis of PA Sling With Tracheal Stenosis
Pulmonary artery sling is a rare congenital pulmonary vascular malformation, often associated with tracheal or bronchial stenosis.
- Trial name
- NCT04383184
- Testing
- tracheoplasty
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Tracheal Stenosis, Laryngeal Stenosis
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
- Conditions
- Tracheal Stenosis, Laryngeal Stenosis, Mesenchymal Stem Cells
- Trial name
- NCT03130374
- Testing
- Olfactory mucosa-derived mesenchymal stem cells
- Where
- 2 sites in Belarus
- Volunteers
- 12 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Disorder of Upper Respiratory System, Laryngostenosis
Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants
This study aims to test a new groundbreaking treatment for narrowing of the voicebox and upper windpipe, which can be due to injury, inflammatory disease or cancer treatment.
- Conditions
- Disorder of Upper Respiratory System, Laryngostenosis, Tracheal Stenosis
- Trial name
- RegenVOX (NCT01977911)
- Testing
- Stem cell based tissue engineered partial laryngeal implants
- Where
- United Kingdom
- Sponsor
- University College, London
Tracheobronchomalacia, Tracheal Stenosis
Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis
It is not clearly understood what causes tracheobronchomalacia (weakening of the windpipe and airways) or tracheal stenosis (narrowing of the windpipe).
- Trial name
- NCT00705848
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Idiopathic Subglottic Stenosis, Subglottic Stenosis (SGS)
A Phase I Evaluation of the Safety and Tolerability of Pirfenidone in Idiopathic Subglottic Stenosis
Idiopathic subglottic stenosis (iSGS) is a rare condition where scar tissue forms just below the vocal cords and in the upper windpipe, making the airway narrow.
- Trial name
- NCT07654517
- Testing
- Pirfenidone 267 MG [Esbriet]
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Apnea+Hypopnea, Tracheal Dilatation
Tracheal Dilatation in Pediatric Patients With Acquired Tracheal Stenosis, and the Effects of Apneic Oxygenation
The study presents an alternative method of tracheal dilatation in pediatric patients with acquired tracheal stenosis. Dilatation is performed by the use of balloon catheter connected with manometer, that is bronchoscopic guided…
- Conditions
- Apnea+Hypopnea, Tracheal Dilatation, Igel, Tracheal Stenosis
- Trial name
- NCT05028023
- Testing
- Apneic oxygenation - supplemental high flow oxygen administration by an apneic way
- Where
- Greece
- Volunteers
- 5 people
- Sponsor
- Aristotle University Of Thessaloniki
Idiopathic Subglottic Tracheal Stenosis
Voice Quality Analysis of Patients With Laryngotracheal Stenosis
The investigators previously demonstrated that voice changes are common in patients with Laryngotracheal Stenosis (LTS), and patients typically report an improvement in voice outcomes following endoscopic dilation.
- Trial name
- NCT06161077
- Testing
- Voice Biomarker Screening Too
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Respiratory Disease, Tracheal Stenosis
Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam
Rigid bronchoscopy usually requires deep general anesthesia, but the duration of the procedure is relatively short. Remimazolam, a recently developed anesthetics, showed faster recovery from anesthesia and stable hemodynamics…
- Conditions
- Respiratory Disease, Tracheal Stenosis, Endobronchial Mass
- Trial name
- NCT05835713
- Testing
- Remimazolam besylate, Propofol
- Sponsor
- Samsung Medical Center
Tracheal Stenosis
Stent Versus Balloon Dilatation in Patients With Tracheal Benign Stenosis
This is a retrospective, observational cohort study carried out in two operative Units of the University Hospital of Modena (Italy): the Diagnostic and Interventional Bronchoscopy Unit (Unit A) and the Otolaryngology Unit (Unit…
- Trial name
- STROBE (NCT04674995)
- Testing
- Stent placement
- Volunteers
- 66 people
- Sponsor
- University of Modena and Reggio Emilia