Clinical trials: Stricture; Trachea, open to volunteers
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children
Feasibility and safety of repairing tracheal and bronchial defects in infants and children using cryopreserved donor aortic patches.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Tuberculosis; Tracheitis, Airway Disease
- Trial name
- NCT07240259
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Stenosis Trachea
Cryospray Therapy for Benign Airway Stenosis
This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome…
- Trial name
- CRYOSTASIS (NCT06085209)
- Testing
- The truFreeze Spray Cryotherapy, Ballon dilation, Radial Incision
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Adult Subjects With Symptomatic Benign Airway Obstruction, Adult Benign Central Airway Stenosis
Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Central Airway Stenosis
The OXYGEN-RCT trial is a randomized, controlled, double blinded, prospective, multi-center trial to demonstrate the safety and efficacy in adult benign central airway stenosis.
- Conditions
- Adult Subjects With Symptomatic Benign Airway Obstruction, Adult Benign Central Airway Stenosis, Adult Tracheobronchial Stenosis, Tracheal Stenosis
- Trial name
- OXYGEN-RCT (NCT07191860)
- Testing
- The Airiver Pulmonary drug-coated balloon (DCB) dilation, Commercial airway balloon dilation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Airiver Medical, Inc.
Idiopathic Subglottic Tracheal Stenosis
Voice Quality Analysis of Patients With Laryngotracheal Stenosis
The investigators previously demonstrated that voice changes are common in patients with Laryngotracheal Stenosis (LTS), and patients typically report an improvement in voice outcomes following endoscopic dilation.
- Trial name
- NCT06161077
- Testing
- Voice Biomarker Screening Too
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Idiopathic Subglottic Stenosis, Subglottic Stenosis (SGS)
Pirfenidone for Idiopathic Subglottic Stenosis: A Pilot Trial of Tolerability and Feasibility
Idiopathic subglottic stenosis (iSGS) is a rare condition where scar tissue forms just below the vocal cords and in the upper windpipe, making the airway narrow.
- Trial name
- NCT07654517
- Testing
- Pirfenidone
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tracheal Stenosis, Subglottic Stenosis
RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis
Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring.
- Trial name
- NCT07258784
- Testing
- Biopsy or surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Laryngotracheal Lesions, Tracheostomy Complications
Laryngotracheal Lesions in Adults With Long-Term Tracheostomy
This multicenter prospective observational cohort study will enroll 224 adults with a tracheostomy tube in place for at least 14 days.
- Conditions
- Laryngotracheal Lesions, Tracheostomy Complications, Tracheal Stenosis, Tracheomalacia
- Trial name
- NCT07901946
- Testing
- Standardized Three-Station Bronchoscopy
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Hongying Jiang, MD
Stenosis of Trachea
Spray Cryotherapy for the Management of Benign Central Airway Stenosis (Cryo-BAS)
The goal of this clinical trial is to compare spray cryotherapy plus balloon dilatation versus current standard of Care (SoC - steroid injection, radial cuts and balloon dilatation) in patients with benign airway stenosis with…
- Trial name
- Cryo-BAS (NCT06761170)
- Testing
- Spray cryo therapy, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheal Stenosis
Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision
Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe.
- Trial name
- NCT07463742
- Testing
- Bronchoscopy, carbon dioxide (CO2) laser wedge resection, Radial incision with dilation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Idiopathic Subglottic Stenosis
Adjuvant Steroid Outcomes in Idiopathic Subglottic Stenosis
This study will examine the ability of steroid injections into the site of stenosis following surgical dilation to delay the need for repeated surgical dilations.
- Trial name
- ASTRO (NCT07228104)
- Testing
- Triamcinolone 0.1%
- Where
- 10 sites in United States
- Volunteers
- 226 people
- Sponsor
- Johns Hopkins University
Tracheal Stenosis, Subglottic Stenosis
Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis
Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.
- Trial name
- NCT06917222
- Testing
- Slide tracheoplasty, Tracheal resection anastomosis
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University Hospital