Clinical trials: Stricture
ATTR Amyloidosis Wild Type, Severe Aortic Stenosis
Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR
ATTR-cardiac amyloidosis (CA) is present in 4% to 16% of elderly patients with severe calcific aortic stenosis (AS). The reasons for this association are not fully known.
- Conditions
- ATTR Amyloidosis Wild Type, Severe Aortic Stenosis, Aortic Valve Stenosis, Middle East Studies
- Trial name
- NCT06015997
- Volunteers
- 100 people
- Sponsor
- Jordan Collaborating Cardiology Group
Atherosclerosis, Arteriosclerosis
BIOLUX P-I First in Man Study
A prospective, multi-centre, randomized controlled, First in Man study to assess the safety and performance of the coated Passeo-18 Lux Paclitaxel releasing PTA Balloon Catheter vs.
- Conditions
- Atherosclerosis, Arteriosclerosis, Vascular Disease, Peripheral Artery Disease
- Trial name
- NCT01221610
- Testing
- Passeo-18 Lux DRB, Standard PTA (POBA)
- Where
- 5 sites in Austria, Germany
- Volunteers
- 60 people
- Sponsor
- Biotronik AG
Peripheral Vascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery for Thrombosis and Bleeding
The proposed PIVOTAL study will examine a panel of platelet/coagulation activity markers during the perioperative period. The goal is to develop a clinically useful assessment of platelet/coagulation activity for risk…
- Conditions
- Peripheral Vascular Disease, Peripheral Artery Disease, Carotid Stenosis, Aortic Aneurysm, Abdominal
- Trial name
- PIVOTAL (NCT01897103)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Back Pain Lower Back, Neck Pain
Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)
This study aims to analyze the efficacy and safety of different kinds of steroid injections for back pain, comparing different steroids, dosages, locations (epidural, facet joints, nerve blocks), and also the difference between…
- Conditions
- Back Pain Lower Back, Neck Pain, Radiculopathy Multiple Sites, Spinal Stenosis Cervicothoracic Region
- Trial name
- CORTISS (NCT07762170)
- Testing
- triamcinolone acetonide (Kenalog), Celestone Soluspan 6Mg/Ml Suspension for Injection, Depo-Medrol 40Mg/Ml Suspension for Injection
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Igor Wilderman. MD
Radiculopathy, Myelopathy Cervical
Fusion Rates of 3D Printed Porous Titanium Cages in Three and Four Level ACDFs
The purpose of this trial is to assess fusion rates in 3 and 4 level ACDFs in patients implanted with DePuy Conduit 3D printed titanium cages supplemented with SKYLINE Anterior Cervical Plate System and 1 CC DBM.
- Conditions
- Radiculopathy, Myelopathy Cervical, Foraminal Stenosis, Central Canal Stenosis
- Trial name
- NCT05696470
- Testing
- DePuy Synthes Conduit 3D printed titanium cages
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Ohio State University
Intra-operative Hypotension, Carotid Stenosis
Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Carotid endarterectomy (CEA) is the recommended treatment for symptomatic high degree stenosis of the internal carotid artery (ICA).
- Trial name
- NCT01451294
- Testing
- Administration of phenylephrine, Administration of ephedrine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- G.J. de Borst
Severe Aortic Stenosis
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement
The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or…
- Trial name
- NCT01240902
- Testing
- Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR)
- Where
- 45 sites in United States
- Volunteers
- 1,453 people
- Sponsor
- Medtronic Cardiovascular
Degenerative Cervical Spinal Stenosis, Cervical Disc Herniation
Multicentric Registry for the Detection of C5 Palsy After Anterior Cervical Discectomy and Fusion
Detect the reason for the frequently occurring C5 palsy after anterior cervical discectomy and fusion
- Conditions
- Degenerative Cervical Spinal Stenosis, Cervical Disc Herniation, Suspected Cervical Spine Instability
- Trial name
- C5registry (NCT02875431)
- Testing
- Patients undergo ACDF or cervical vertebral body replacement
- Where
- Germany
- Volunteers
- 1,087 people
- Sponsor
- Technical University of Munich
Aortic Valve Stenosis, AV Block
Prospective Arm of Conduct - Edwards SAPIEN3 PPI Registry
There are procedure related risk factors for permanent pacemaker implantation (PPI) that can be identified and assessed in a prospective cohort of 300 patients at high risk for PPI Prospective, multicenter, European registry in…
- Conditions
- Aortic Valve Stenosis, AV Block, Bundle-Branch Block
- Trial name
- Conduct-pro (NCT03715894)
- Testing
- transcatheter valve implantation
- Where
- 5 sites in Germany, Netherlands and 1 more
- Volunteers
- 300 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Erectile Dysfunction, Peripheral Arterial Disease
Selution Sirolimus-eluting Balloon for Internal Pudendal-penile Artery Disease-related Erectile Dysfunction
According to epidemiological surveys in various countries around the world, the prevalence of erectile dysfunction in men over the age of 40 is about 40%.
- Conditions
- Erectile Dysfunction, Peripheral Arterial Disease, Arterial Stenosis
- Trial name
- NCT05362994
- Testing
- Selution SLR™ sirolimus-eluting balloon, Plain old balloon angioplasty
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- National Taiwan University Hospital
Tracheal Stenosis
Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients
tracheal stenosis is the result of abnormal wound-healing processes leading to hypertrophic scar formation and obstruction of the airway lumen by excess granulation tissue.
- Trial name
- NCT02855502
- Testing
- Prednisolone
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- National Research Institute of Tuberculosis and Lung Disease, Iran
Intracranial Artery Stenosis
Gut Microbiota and Prognostic Outcomes in Intracranial Arterial Stenosis Patients（GROW-ICAS）
GROW-ICAS (Gut microBiota and prOgnostic Outcomes in IntraCranial Arterial Stenosis) is a prospective observational cohort study that enrolls patients with intracranial arterial stenosis to investigate the correlations between…
- Trial name
- NCT07085299
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Tracheal Stenosis, Subglottic Stenosis
RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis
Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring.
- Trial name
- NCT07258784
- Testing
- Biopsy or surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Peripheral Artery Disease
Acoart SCB SFA: Sirolimus Coated Balloon Catheter in the Treatment of Femoropopliteal Artery Stenosis
A prospective randomized trial designed to compare the efficacy and safety of Sirolimus coated balloon (SCB) versus paclitaxel coated balloon (DCB) in the treatment of femoropopliteal artery stenosis
- Trial name
- NCT04982367
- Testing
- Sirolimus-eluting balloon catheter, Paclitaxel-eluting balloon catheter
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Acotec Scientific Co., Ltd
Aortic Valve Disease, Aortic Valve Insufficiency
J-Valve Compassionate Use
J-Valve TF Compassionate Use cases approved on a case by case basis by the FDA
- Conditions
- Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Stenosis
- Trial name
- NCT03876964
- Testing
- Transcatheter Aortic Valve Replacement
- Sponsor
- JC Medical, Inc., an affiliate of Edwards Lifesciences LLC
In-stent Stenosis of Infrapopliteal Arteries
Paclitaxel-Coated Versus Uncoated Balloon for Treatment of Below-the-Knee In-Stent-Restenosis
There is both a poor life expectancy and a poor prognosis of limb salvage in those patience with stenoses or occlusions of the lower limb.
- Trial name
- BAIR (NCT01398033)
- Testing
- paclitaxel-coated balloon, non-coated balloon
- Where
- Germany
- Sponsor
- Herz-Zentrums Bad Krozingen
Coronary Disease, Coronary Artery Disease
EXecutive RCT: Evaluating XIENCE V® in a Multi Vessel Disease
The purpose of this two part study is the assessment of the performance of the XIENCE V® Everolimus Eluting Coronary Stent System (XIENCE V® EECSS) in the treatment of the specific setting of patients with Multi-Vessel Coronary…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis
- Trial name
- EXecutive (NCT00531011)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent System, TAXUS® Liberté™ Paclitaxel Eluting Coronary Stent System
- Where
- 24 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
First or Second Uretral Stenosis, Diagnosed With Uretral Fibroscopy
TREatment of Uretral STRICTure With Self-catheterization : Tolerance Evaluation
Urethral stenosis has a recurrent character. The clean intermittent self-catheterization can be proposed for repeat stenosis. This study seeks to explore the tolerance of clean intermittent self-catheterization in the evolution…
- Trial name
- TRESTRICTT (NCT03948009)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Coronary Cicrovascular Dysfunction, Hypertrophic Cardiomyopathy Patients
Prognostic Significance of CMD Assessed by IMR in HCM Patients
The index of microcirculatory resistance (IMR) serves as an indicator of coronary microvascular dysfunction (CMD) with significant prognostic value in various clinical conditions.
- Trial name
- caIMR-HCM (NCT06190704)
- Testing
- caIMR
- Volunteers
- 191 people
- Sponsor
- Ya-Wei Xu
Crohn Disease, Inflammatory Bowel Diseases
Stricture Definition and Treatment (STRIDENT) Endoscopic Therapy Study
Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Stricture; Bowel
- Trial name
- STRIDENT (NCT03222011)
- Testing
- Standard (single) endoscopic stricture dilatation, Intensive endoscopic stricture dilatation
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- St Vincent's Hospital Melbourne
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